Results 31 to 40 of about 3,028 (210)

A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator. [PDF]

Sci Rep, 2015
AbstractMiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common targets. In one cluster containing three miRNAs, miR-612, miR-661 and miR-940, the annotated functions of the co ...
Bhajun R, Guyon L, Pitaval A, Sulpice E, Combe S, Obeid P, Haguet V, Ghorbel I, Lajaunie C, Gidrol X.   +9 more
europepmc   +5 more sources

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance Prostate cancer is one of most common cancers in men worldwide, and osteoblastic bone metastasis is frequently observed in prostate cancer patients. However, the mechanisms responsible for the predominantly osteoblastic phenotype have not been fully elucidated.
Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S.   +14 more
europepmc   +4 more sources

Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. [PDF]

Oncotarget, 2014
The elucidation of chemoresistance mechanisms is important to improve cancer patient survival. In this report, we investigated the role and mechanism through which receptor-interacting protein 1 (RIP1), a mediator in cell survival and death signaling, participates in cancer's response to chemotherapy.
Wang Q, Shi S, He W, Padilla MT, Zhang L, Wang X, Zhang B, Lin Y.   +7 more
europepmc   +4 more sources

Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection. [PDF]

Cancer Biomark, 2018
BACKGROUND: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Zhuo X, Zhou W, Li D, Chang A, Wang Y, Wu Y, Zhou Q.   +6 more
europepmc   +3 more sources

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients. [PDF]

Oncotarget, 2016
Congestive heart failure (CHF) is a major cause of hospitalizations, morbidity, and mortality in Western societies. In addition to optimal medical and device therapy, exercise training is an important adjunct treatment option for CHF patients. MicroRNAs (miRNAs, miRs) participate in a variety of physiological and pathological processes.
Xu T, Zhou Q, Che L, Das S, Wang L, Jiang J, Li G, Xu J, Yao J, Wang H, Dai Y, Xiao J.   +11 more
europepmc   +6 more sources

miR-940 Upregulation Suppresses Cell Proliferation and Induces Apoptosis by Targeting PKC-δ in Ovarian Cancer OVCAR3 Cells.

Oncol Res, 2017
Ovarian cancer remains as one of the most threatening malignancies for females in the world. This study investigated the pivotal role of miR-940 in the progression of ovarian cancer and to reveal the possible molecular mechanism of its action. Ovarian cancer OVCAR3 cells were transfected with the miR-940 vector, miR-940 inhibitor, and/or small ...
Wang F, Wang Z, Gu X, Cui J.
europepmc   +4 more sources

The Effect of miR-940 Up-regultion on HbF and Erythroid Markers Expression in k-562 Cell Line [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Fetal hemoglobin (α2γ2) is the main oxygen transport protein in the human fetus. Fetal hemoglobin is nearly completely replaced by hemoglobin A, except in a few thalassemia cases and sickle cell anemia.
Hengamesadat Razavi, Shaban Alizadeh, Amir Atashi, Parvin Rahmani   +3 more
doaj   +1 more source

Identification of novel exosomal miRNAs and their role in diagnosis and prognosis of triple negative breast cancer [PDF]

BMC Cancer
Triple-negative breast cancer (TNBC) is a clinically aggressive subtype characterized by poor prognosis and limited therapeutic options. Exosomal microRNAs (miRNAs), enclosed within secretory vesicles, have emerged as promising non-invasive biomarkers ...
Ananya Choudhary, Satish S. Poojary, Priyanka Jain, Harit Chaturvedi, Bhudev C. Das   +4 more
doaj   +2 more sources

Salvianolic acid A modulates α-Ketoisovaleric acid metabolism to inhibit human cartilage endplate cells apoptosis under mechanical tensile stress [PDF]

Scientific Reports
Intervertebral disc degeneration (IDD) represents a key contributor to chronic back pain and cartilage endplate cell (CEPCs) are mechanically sensitive. Salvianolic acid A (SAA), a polyphenolic compound of traditional Chinese medicine Salvia miltiorrhiza,
Yuxuan Du, Ke Zhao, Chong Liu, Gewen Wang, Yupeng Liang, Chuhao Cai, Weiye Zhang, Wu Sun, Zhefeng Jin, Jia Ma, Tao Han, Hongyu Yang, Liguo Zhu, Jiawen Zhan, Minshan Feng   +14 more
doaj   +2 more sources

MiR-940 inhibits the progression of NSCLC by targeting FAM83F.

European review for medical and pharmacological sciences, 2018
We investigate whether miR-940 could target family sequence similarity 83 member F (FAM83F) and further inhibit the progression of non-small cell lung cancer (NSCLC).The expression levels of miR-940 and FAM83F in tumor tissues and paracancerous tissues of 72 NSCLC patients were detected through quantitative real time-polymerase chain reaction (qRT-PCR).
Gu, G.-M., Zhan, Y.-Y., Abuduwaili, K., Wang, X.-L., Li, X.-Q., Zhu, H.-G., Liu, C.-L.   +6 more
openaire   +2 more sources