Results 41 to 50 of about 31,458 (257)
Molecular Therapy: Nucleic Acids, 2020 Immune thrombocytopenia (ITP) is a common hematological autoimmune disease, in which defective mesenchymal stem cells (MSCs) are potentially involved. Our previous study suggested that MSCs in ITP patients displayed enhanced apoptosis. MicroRNAs (miRNAs)
Yanan Wang +12 more
doaj +1 more source
LncRNA XIST regulates atherosclerosis progression in ox-LDL-induced HUVECs
Open Medicine, 2021 Long noncoding RNAs (lncRNAs) have been verified as vital regulators in human disease, including atherosclerosis. However, the precise role of X-inactive-specific transcript (XIST) in atherosclerosis remains unclear.
Gao Hongmei, Guo Zhaohui
doaj +1 more source
Mechanism of miR-98-5p in gastric cancer cell proliferation, migration, and invasion through the USP44/CTCFL axis. [PDF]
Toxicol Res (Camb)Abstract Objectives Gastric cancer (GC) is the leading digestive malignancy with high incidence and mortality rate. microRNAs (miRs) play an important role in GC progresssion. This study aimed to investigate the effect of miR-98-5p on proliferation, migration, and invasion of GC cells.
Zhang K +13 more
europepmc +3 more sources
MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation [PDF]
, 2014 MYCN is a transcription factor that plays key roles in both normal development and cancer. In neuroblastoma, MYCN acts as a major oncogenic driver through pleiotropic effects controlled by multiple protein encoding genes as well as microRNAs (miRNAs ...
Althoff, Kristina +11 more
core +3 more sources
CCNF is a potential pancancer biomarker and immunotherapy target [PDF]
, 2023 BackgroundCCNF catalyzes the transfer of ubiquitin molecules from E2 ubiquitin-conjugating enzymes to target proteins, thereby regulating the G1/S or G2/M transition of tumor cells. Thus far, CCNF expression and its potential as a pancancer biomarker and
Cuiling Zhou +6 more
core +1 more source
Biomarkers in Overactive Bladder [PDF]
, 2020 146-150Nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), cytokines, stem cell factor etc. are some promising biomarkers for overactive bladder (OAB).
Bandyopadhyay, Soma, Pal, Manidip
core +4 more sources
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes. [PDF]
RNA Biol, 2020 Although deregulated circulatory miRNA signatures during diabetes have been identified for some years now, the effects of such miRNAs on several target tissues are not yet thoroughly investigated. The skin that is nourished by components present in the circulation exhibits several notable abnormal features during diabetes.
Khan R +5 more
europepmc +4 more sources
Cancer Cell International, 2019 Background Ovarian cancer (OC) is a gynecological malignancy with a high mortality. Cisplatin-based treatment is the typical treatment regimen for OC patients; however, it may cause unfavorable resistance.
Hua Guo +5 more
doaj +1 more source
Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment [PDF]
, 2015 Cancer inducible molecular chaperone HSP90 is of great importance as an anticancer target. Proteomic analysis showed that inhibiting HSP90 by the geldanamycin derivative, 17-AAG elevated the expression of the co-chaperone Hsp70.
Patil, Harshada Shashikant +2 more
core +1 more source
MiR-98-5p regulates myocardial differentiation of mesenchymal stem cells by targeting TBX5.
European review for medical and pharmacological sciences, 2018 This study aims to investigate whether miR-98-5p can participate in the myocardial differentiation of bone marrow mesenchymal stem cells (MSCs) by regulating TBX5.In this study, we first identified the MSCs that were isolated from rat bone marrow samples.
Sun, H.-H., Sun, P.-F., Liu, W.-Y.
openaire +2 more sources