Introduction. Testicular germ cell tumor is a relatively rare disease. Its high social significance is due to the fact that this pathology occurs in young patients. The standard schemes of polychemotherapy determine the potential possibility of effective treatment for most of the patients even with an advanced disease.
M. S. Knyazeva +10 more
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Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome [PDF]
Introduction: Alterations in certain microRNAs (miRNAs) and their target genes have reported in polycystic ovary syndrome (PCOS) and other disease of the female reproductive system, and so may be potential biomarkers. We hypothesised alterations in the prevalence of four miRNAs single nucleotide polymorphism (SNP) variants miR-126 rs4636297, miR-146a ...
Li, R. +6 more
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Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer [PDF]
MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and ...
Schee Kristina +4 more
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Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients [PDF]
Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC.Seven microRNAs (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429) were quantified in the serum of 180 ...
Xiaodan Meng +8 more
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miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF [PDF]
Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that regulates brain development, synaptogenesis, memory and learning, as well as development of peripheral organs, such as angiogenesis in the heart and postnatal growth and repair of skeletal muscle.
Varendi, Kärt +3 more
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The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar rats [PDF]
Purpose: Bones are largely influenced by nutrition, activity levels and lifestyle, and structural adaptations in the form and size of the bone occur by the forces of weight bearing and forces applied by the muscles.
ZAHRA HEMATI FARSANI +3 more
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The scientific review presents the mechanisms of action of intranuclear miRNAs, namely microRNA-mediated regulation of the non-coding RNA (ncRNA) transcriptome and alternative splicing.
A.E. Abaturov, V.L. Babуch
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miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging [PDF]
SummaryAging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically encoded repair systems. To better understand the genetic component of aging, many studies have addressed the gene and protein expression profiles of various aging model systems engaging different ...
Strasser, A. +27 more
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Problemática y tratamiento actual de la seudoartrosis de escafoides
La fractura de escafoides es la más frecuente del carpo y es inherentemente inestable, por lo que aún con tratamiento precoz puede evolucionar hacia la seudoartrosis hasta en un 55% de los casos.
A. Luis Calero +3 more
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The role of microRNA in the development of liver diseases. Part 2
The scientific review shows the role of miRNA in the development of liver diseases, namely hepatocellular carcinoma. To write the article, we have searched for information in the Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global ...
A.E. Abaturov, V.L. Babуch
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