Results 21 to 30 of about 340,419 (317)
MMpred: functional miRNA – mRNA interaction analyses by miRNA expression prediction [PDF]
, 2012 Background: MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets.
Wilson, Paul +5 more
core +1 more source
, 2023 BackgroundMany researchers focused on diverse miRNAs in the progression of osteoporosis in postmenopausal women. This study aimed to evaluate the association between plasma miRNA-21-5p and miRNA-422a with osteoporosis in postmenopausal women.MethodsThis ...
Alireza Ostadrahimi (8951063) +2 more
core +1 more source
miR-34 – A microRNA Replacement Therapy Is Headed to the Clinic
Frontiers in Genetics, 2012 MicroRNA-34 is a master regulator of tumor suppression. It is downregulated in numerous cancers and inhibits malignant growth by repressing genes involved in various oncogenic signaling pathways.
Andreas G Bader
doaj +1 more source
Mechanisms of non-coding RNA-modulated alternative splicing in cancer
RNA Biology, 2022 Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang +6 more
doaj +1 more source
, 2009 Background MicroRNAs (miRNAs), short ~21-nucleotide RNA molecules, play an important role in post-transcriptional regulation of gene expression. The number of known miRNA hairpins registered in the miRBase database is rapidly increasing, but recent ...
Roeland CHJ van Ham +13 more
core +1 more source
Expression of miRNA-451 and miRNA-885 in Meningiomas
In Vivo, 2023 Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation.
Ozgur, Baran +12 more
openaire +3 more sources
Deciphering miRNAs’ Action through miRNA Editing [PDF]
International Journal of Molecular Sciences, 2019 MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. The outcome of a myriad of physiological processes and pathologies, including cancer, cardiovascular and metabolic diseases, relies ...
Correia De Sousa, Marta +4 more
openaire +4 more sources
Exploring Biomarkers for Alzheimer’s Disease [PDF]
Journal of Clinical and Diagnostic Research, 2016 Alzheimer’s Disease (AD) is one of the most common form of dementia occurring in elderly population worldwide. Currently Aβ42, tau and p-tau in the cerebrospinal fluid is estimated for confirmation of AD. CSF which is being used as the potent source for
Neeti Sharma, Anshika Nikita Singh
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011 Adenovirus infection has a tremendous impact on the cellular silencing machinery. Adenoviruses express high amounts of non-coding virus associated (VA) RNAs able to saturate key factors of the RNA interference (RNAi) processing pathway, such as Exportin 5 and Dicer. Furthermore, a proportion of VA RNAs is cleaved by Dicer into viral microRNAs (mivaRNAs)
Carnero, Elena +2 more
openaire +2 more sources
The American Journal of Pathology, 2009 Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally.
Rosa, Visone, Carlo M, Croce
openaire +2 more sources