Results 261 to 270 of about 208,585 (280)
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Nature Genetics, 2000
The DNA repair picture in humans becomes more complete with the identification of MLH3, a homologue of MutL and a heterodimeric partner of MLH1.
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The DNA repair picture in humans becomes more complete with the identification of MLH3, a homologue of MutL and a heterodimeric partner of MLH1.
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2010
The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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DNA mismatch repair: MutS structures bound to mismatches
Current Opinion in Structural Biology, 2001When DNA mismatch repair fails, the result is a mutator phenotype, which can lead to cancer in humans. Functional repair is dependent on the recognition of mismatches by a dimeric MutS protein, a homodimer in bacteria but a heterodimer in humans. Recent crystal structures of Thermus aquaticus and Escherichia coli MutS have revealed the structural ...
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DNA mismatch repair and cancer
Mutation Research/Reviews in Mutation Research, 2001Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
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Gan to kagaku ryoho. Cancer & chemotherapy, 1997
A DNA mismatch repair system exists that repairs mispaired bases formed during DNA replication and genetic recombination. Genetic defects in this mismatch repair system are known to increase the rate of spontaneous mutation in Escherichia coli. Some cases of inherited cancer are associated with inherited defects of mismatch repair genes, showing the ...
M, Ikejima, T, Shimada
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A DNA mismatch repair system exists that repairs mispaired bases formed during DNA replication and genetic recombination. Genetic defects in this mismatch repair system are known to increase the rate of spontaneous mutation in Escherichia coli. Some cases of inherited cancer are associated with inherited defects of mismatch repair genes, showing the ...
M, Ikejima, T, Shimada
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2016
The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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The DNA replication machinery synthesizes ~500 DNA base pairs every second in bacteria and ~50 base pairs every second in eukaryotes [1]. Mismatches can occur in a newly synthesized DNA due to misincorporation of nucleotides by DNA polymerase or slippage during DNA replication.
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