Results 131 to 140 of about 921,496 (243)
ENTRE DOIS MUNDOS: O Sincretismo religioso no mito arthuriano [PDF]
, 2014 TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Filosofia e Ciências Humanas, Departamento de História.Por ser um dos mitos mais importantes e difundidos no período medieval, as histórias sobre o Rei Arthur e os Cavaleiros da Távola ...
Daniel, Thayse Catarina
core
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Cladistics, EarlyView.Abstract Replicated pairs of ancestral and evolutionarily derived populations provide opportunities to test hypotheses about the deterministic laws of evolution. The Asellus aquaticus species complex is an invertebrate model system with several independent surface‐to‐cave transitions and a complicated and unresolved evolutionary history.
Peter Trontelj +3 more
wiley +1 more source
A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells
Cell Proliferation, EarlyView.This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang +10 more
wiley +1 more source
Cell Proliferation, EarlyView.PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang +7 more
wiley +1 more source
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
Cell Proliferation, EarlyView.Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang +11 more
wiley +1 more source
Mito-nuclear incompatibility disrupts ACOX1/ACOX3-mediated mitochondria-peroxisome metabolic coordination in black soldier flies. [PDF]
Mol Biol EvolWang X +7 more
europepmc +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
The FEBS Journal, EarlyView.AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source