Results 51 to 60 of about 17,423 (206)

A Chromosome-Length Reference Genome for the Endangered Pacific Pocket Mouse Reveals Recent Inbreeding in a Historically Large Population [PDF]

, 2022
High-quality reference genomes are fundamental tools for understanding population history, and can provide estimates of genetic and demographic parameters relevant to the conservation of biodiversity.
Curry , C., Daly, M., Dudchenko , O., Fronczek, J., Houck , M., Khan , R., Korody , M., Lieberman Aiden , E., Misuraca , A., Ryder , O., Shier , D., Steiner , C., Turbek , S., Wang, G., Weisz, D., Wilder , A.   +15 more
core   +2 more sources

The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates

BMC Genomics, 2023
The mitochondria are central in the cellular response to changing environmental conditions resulting from disease states, environmental exposures or normal physiological processes.
John Lees, Fábio Pèrtille, Pia Løtvedt, Per Jensen, Carlos Guerrero Bosagna   +4 more
doaj   +1 more source

Mitochondrial and plastid genome variability of Corallina officials (Corallinales, Rhodophyta) [PDF]

, 2020
Corallina officinalis is a calcifying red alga, common in tide pools in the North Atlantic with occasional reports from the north-east Pacific. It is an important habitat-forming alga, providing shelter and substrata to many other organisms.
Bian, Xueni, Briscoe, Andrew G., Brodie, Juliet, Williamson, Christopher, Yesson, Chris   +4 more
core   +2 more sources

ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Journal of Experimental & Clinical Cancer Research, 2023
Background Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis.
Pingping Su, Xiaodan Mao, Jincheng Ma, Lixiang Huang, Lirui Yu, Shuting Tang, Mingzhi Zhuang, Zhonglei Lu, Kelvin Stefan Osafo, Yuan Ren, Xinrui Wang, Xite Lin, Leyi Huang, Xiaoli Huang, Elena Ioana Braicu, Jalid Sehouli, Pengming Sun   +16 more
doaj   +1 more source

Complete mitochondrial genomes of the freshwater mussels Amblema plicata (Say, 1817), Pleurobema oviforme (Conrad, 1834), and Popenaias popeii (Lea, 1857) (Bivalvia: Unionidae: Ambleminae) [PDF]

, 2020
Freshwater mussels are a critically imperiled group of mollusks that play key ecological roles and provide important services to humans. The Ambleminae is the only subfamily of these mussels, endemic to North America.
Aldridge, David C., Bogan, Arthur E., Bolotov, Ivan N., Burlakova, Lyubov E., Froufe, Elsa, Gomes-dos-Santos, André, Karatayev, Alexander Y., Lopes-Lima, Manuel, Teiga-Teixeira, João, Teixeira, Amílcar, Varandas, Simone, Vikhrev, Ilya V., Zanatta, David T.   +12 more
core   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Complete mitochondrial genome of Prismognathus prossi (Coleoptera: Lucanidae) with phylogenetic implications [PDF]

, 2019
The complete mitochondrial genome of a Chinese stag beetle, Prismognathus prossi, was generated using the Illumina next-generation sequencing. The mitogenome sequence is 15,984 bp in length, the nucleotide composition isA 36.6%, C17.5%, T34.3% andG11.6 ...
Cao, Y., Chen, Y., Liu, J., Wan, X., Zhou, S.   +4 more
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Genomic patterns of divergence in the early and late steps of speciation of the deep-sea vent thermophilic worms of the genus Alvinella

BMC Ecology and Evolution, 2022
Background The transient and fragmented nature of the deep-sea hydrothermal environment made of ridge subduction, plate collision and the emergence of new rifts is currently acting to separate of vent populations, promoting local adaptation and ...
Camille Thomas-Bulle, Denis Bertrand, Niranjan Nagarajan, Richard R. Copley, Erwan Corre, Stéphane Hourdez, Éric Bonnivard, Adam Claridge-Chang, Didier Jollivet   +8 more
doaj   +1 more source