Results 51 to 60 of about 921,496 (243)

Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8)

Scientific Reports
Mitochondrial genome mutations are associated with various diseases and gene therapy targeted to mitochondria has the potential to effectively treat such diseases.
Kaede Norota, Sen Ishizuka, Misa Hirose, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Saleh M. Ibrahim, Hideyoshi Harashima, Yuma Yamada   +8 more
doaj   +1 more source

Mito‐nuclear discordance at a mimicry color transition zone in bumble bee Bombus melanopygus

Ecology and Evolution, 2021
As hybrid zones exhibit selective patterns of gene flow between otherwise distinct lineages, they can be especially valuable for informing processes of microevolution and speciation.
Briana E. Wham, Sarthok Rasique Rahman, Marena Martinez‐Correa, Heather M. Hines   +3 more
doaj   +1 more source

Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming

Frontiers in Oncology, 2022
BackgroundThymidine kinase 1 (TK1) is a cell cycle-dependent kinase that catalyzes the addition of a gamma-phosphate group to thymidine. The protumorigenic role of TK1 has been reported in various malignancies.
Sipeng Zuo, Sipeng Zuo, Huixue Wang, Huixue Wang, Lin Li, Lin Li, Hui Pan, Hui Pan, Linna Lu, Linna Lu   +9 more
doaj   +1 more source

Draft genome sequence of Komagataeibacter rhaeticus Strain AF1, a high producer of cellulose, isolated from kombucha tea

, 2014
Here, we present the draft genome sequence of Komagatabaeicter rhaeticus strain AF1, which was isolated from Kombucha tea and is capable of producing high levels of cellulose.Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Laboratório ...
Santos, Renato Augusto Corrêa dos, Zucchi, Tiago Domingues, dos Santos, Renato Augusto Corrêa, Berretta, Andresa A., Ribeiro, Sidney José Lima [UNESP], Goldman, Gustavo H., Barud, Hernane da Silva [UNESP], González-García, Laura Natalia, Riaño-Pachón, Diego M., Ribeiro, Sidney José Lima, Barud, Hernane da Silva   +10 more
core   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

A new species of Rhyacophila Pictet, 1834 (Trichoptera, Rhyacophilidae) from Corsica with the genomic characterization of the holotype [PDF]

ZooKeys
We describe a new species in the Rhyacophila tristis group, Rhyacophila lignumvallis Graf & Rázuri-Gonzales, sp. nov., from the island of Corsica (France) based on a single male specimen.
Ernesto Rázuri-Gonzales, Wolfram Graf, Jacqueline Heckenhauer, Julio V. Schneider, Steffen U. Pauls   +4 more
doaj   +3 more sources

Genomic patterns of divergence in the early and late steps of speciation of the deep-sea vent thermophilic worms of the genus Alvinella

BMC Ecology and Evolution, 2022
Background The transient and fragmented nature of the deep-sea hydrothermal environment made of ridge subduction, plate collision and the emergence of new rifts is currently acting to separate of vent populations, promoting local adaptation and ...
Camille Thomas-Bulle, Denis Bertrand, Niranjan Nagarajan, Richard R. Copley, Erwan Corre, Stéphane Hourdez, Éric Bonnivard, Adam Claridge-Chang, Didier Jollivet   +8 more
doaj   +1 more source

O mito em jogo : um estudo do romance a obscena senhora D de Hilda Hilst [PDF]

, 1989
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Comunicação e ExpressãoO presente trabalho se propõe a uma abordagem mítica do romance "A Obscena Senhora D", de Hilda Hilst. Para atingir este objetivo, levantamos os componentes
Todeschini, Maria Thereza
core  

Primers for the PCR amplifications of Episymploce splendens (Es) mito-genome and Numts.

, 2022
Primers for the PCR amplifications of Episymploce splendens (Es) mito-genome and Numts.
Zhenzhen Hou (12733598), Hongmei Wang (190581), Bisong Yue (314087), Qin Chen (44010), Jinnan Ma (4015010), Xiuyue Zhang (321082), Chenjuan Zeng (4414864), Jie Gao (10266), Lin Yan (53104)   +8 more
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source