Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming
Frontiers in Oncology, 2022 BackgroundThymidine kinase 1 (TK1) is a cell cycle-dependent kinase that catalyzes the addition of a gamma-phosphate group to thymidine. The protumorigenic role of TK1 has been reported in various malignancies.
Sipeng Zuo +9 more
doaj +1 more source
The first mitochondrial 5-methylcytosine map in a non-model teleost (Oreochromis niloticus) reveals extensive strand-specific and non-CpG methylation [PDF]
, 2021 DNA methylation is one of the main epigenetic mechanisms that regulate gene expression in a manner that depends on the genomic context and varies considerably across taxa.
Fernandes, Jorge M.O. +5 more
core +4 more sources
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
Mito‐nuclear discordance at a mimicry color transition zone in bumble bee Bombus melanopygus
Ecology and Evolution, 2021 As hybrid zones exhibit selective patterns of gene flow between otherwise distinct lineages, they can be especially valuable for informing processes of microevolution and speciation.
Briana E. Wham +3 more
doaj +1 more source
Advanced Science, EarlyView.Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li +15 more
wiley +1 more source
Extensive introgression among strongylocentrotid sea urchins revealed by phylogenomics
Ecology and Evolution, 2023 Gametic isolation is thought to play an important role in the evolution of reproductive isolation in broadcast‐spawning marine invertebrates. However, it is unclear whether gametic isolation commonly evolves early in the speciation process or only ...
Matthew R. Glasenapp, Grant H. Pogson
doaj +1 more source
Characterization of the Complete Mitochondrial Genomes of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae) [PDF]
, 2012 The complete mitochondrial genomes (mitogenomes) of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae) were determined and analyzed. The circular genomes were 15,388 bp long for C. medinalis and 15,395 bp long for C.
Chai, Huan-Na +2 more
core +2 more sources
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
A new species of Rhyacophila Pictet, 1834 (Trichoptera, Rhyacophilidae) from Corsica with the genomic characterization of the holotype [PDF]
ZooKeysWe describe a new species in the Rhyacophila tristis group, Rhyacophila lignumvallis Graf & Rázuri-Gonzales, sp. nov., from the island of Corsica (France) based on a single male specimen.
Ernesto Rázuri-Gonzales +4 more
doaj +3 more sources
Somatic mtDNA mutation spectra in the aging human putamen. [PDF]
PLoS Genetics, 2013 The accumulation of heteroplasmic mitochondrial DNA (mtDNA) deletions and single nucleotide variants (SNVs) is a well-accepted facet of the biology of aging, yet comprehensive mutation spectra have not been described.
Siôn L Williams +3 more
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