Results 81 to 90 of about 921,496 (243)
SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu +12 morewiley +1 more sourceSIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis
Advanced Science, EarlyView.The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He +6 morewiley +1 more sourceTargeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou +17 morewiley +1 more sourceGenome sequence of the pea aphid Acyrthosiphon pisum [PDF]
, 2010 Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity.Fenton, Brian, Schneider, M., Nazareth, LV, Smagghe, G., Eisen, Jonathan A., Hilgarth, RS, Hlavina, W., Gordon, K., Christiaens, Olivier, Moen, C., Jiang, H., Williamson, Michael, Vellozo, A, Altincicek, B, Gilbert, Don, Cortes, T, Wright, Rita A., Bickel, Ryan D, Aguilar, J, Wilson, Alex CC, Dang, P.M., Davis, G.K., Brault, V, Hilgarth, Roland S., Lu, Hsiao-Ling, Patel, BM, Vilcinskas, A, Parker, Ben J., Gerardo, Nicole M, Chacko, Joseph, The International Aphid Genomics Consortium, Duncan, Elizabeth J, Evans, J, Davies, T. G. E., Chen, H.-C., Fitzroy, Carol I. J., Monsion, Baptiste, Seah, S., Butts, Thomas, Anselme, C, Hurwitz, B., Robertson, Hugh M, Wilson, Megan, Pechuan, X., Rahbe, Yvan, Dombrovsky, A., Cass, Bodil, Pérez-Brocal, V., Carolan, J.C., Miyagishima, S-Y, Ollivier, M., Leonardo, Teresa, Wilson, M, Jones, D.H., Futami, R, Kushlan, P.F., Zhang, Jingkun, Gabisi, R.A., Douglas, AE, Price, D.R.G., Lu, H.-L., Gatehouse, John A., Price, Daniel R.G., Hauser, F, Ortiz-Rivas, Benjamin, Richards, S, He, X-L, Collin, O., Chandrabose, Mimi N, Thibaud-Nissen, Françoise Françoise, Futami, R., Chen, H-C, Pechuan, X, et al., Joshi, V, Tamborindeguy, Cecilia, Kamins, A, Ollivier, Morgane, Smith, J., Kiryutin, B, Collin, Olivier, Atsushi, Nakabachi, Huerta-Cepas, Jaime, Dinh, HH, Schwartz, Julia, Kaloshian, I., Ishikawa, Asano, Sattelle, D., Smagghe, G, Vieira, Filipe G, Dang, Phat M., van der Zee, Maurijn, Gilbert, D, Veenstra, Jan A., Fowler, Gerald R, Ermolaeva, O., Lee, SL, Tamames, J., Walsh, T.K., de Vos, Martin, Evans, Jay, Legeai, F, Ashton, Peter D., Gabisi, RA, Hlavina, W, Moen, Charles, Hunnicutt, L., Jaubert-Possamai, S, Kamins, A., Barribeau, Seth M., Hedges, D, Heckel, David G., Lozado, Ryan J, Liu, Y-S, Diaz, J, Nikoh, N, Singh, K, Zhou, J-J, Hilgarth, R.S., Wilson, Alexandra, Souvorov, Alexandre, Hume, J, Tamarit, Daniel,, Stafflinger, E, Colella, S., Stanke, M, Huerta-Cepas, J., Consortium, The International Aphid Genomics, Davies, TG Emyr, Wilson, ACC, Huerta-Cepas, J, Williams Jr., R.L., Kosarev, P., Miyagishima, Shin-ya, Nakabachi, A., Christiaens, O, Rispe, C., Singh, Karam, Davies, TGE, Lewis, Lora R., Dinh, H.H., Camara, F, Schwartz, J., Barribeau, S.M., Ishikawa, A, Gauthier, Jean Pierre, Caillaud, Marina, Ren, Q., Rozas, Julio, Muzny, D, Cass, B, Monsion, B, Parker, BJ, Mariotti, M., Leonardo, T., Douglas, Angela, Muzny, Donna, Srinivasan, Dayalan, Gerardo, NM, Reeck, Gerald R, Sagot, MF, Campbell, Peter, Jaubert-Possamai, S., Hunnicutt, Laura, Hitchens, Matthew E, Kamphuis, Lars G., Miura, T, Wilson, Alex C. C., Davis, Gregory K., Gabaldon, Toni, Ermolaeva, O, Vattathil, Selina, Davies, T G Emyr, Joshi, V., Ju, Ho-Jong, Field, Linda M, Schneider, Martina, Carolan, James C, Price, Daniel RG, Cortes, Teresa, Reardon, Karen T., Brisson, J.A., Morioka, M., Velarde, R., Williamson, Martin S, Moya, A., Charles, Hubert, Moya, A, Kapustin, Yuri, Pruitt, K., Heckel, David G, Santibanez, Jireh, Field, Linda M., Fowler, GR, Lee, Sandra L., Chacko, J, Chandrabose, M.N., Huybrechts, Jurgen, Hansen, Karina K, Robertson, HM, Parker, Ben J, Fitzroy, Carol I.J., Zhou, Jing-Jiang, Jr, WRL, Vincent-Monegat, Carole, Miura, T., Câmara, F., Smith, James, Macdonald, S., Heckel, D.G., Muzny, D., Cree, A, Iga, M, Chacko, J., Hunter, W, Cree, Andy, Jiang, H, Wilkinson, T.L., Gauthier, Jean-Pierre, Pechuan, Ximo, Kudo, Toshiaki, Grimmelikhuijzen, C.J.P., Morioka, M, Robertson, H.M., Kamphuis, L.G., Morioka, Mizue, Thomas, G., Tagu, Denis, Hitchens, Matthew E., Degnan, P, Van Der Zee, M., Barribeau, Seth M, Kaloshian, Isgouhi, Atamian, H., Gatehouse, John A, Stafflinger, E., Schneider, M, Alioto, T, Tamborindeguy, C, Maglott, Donna, Hines, S., Vilcinskas, A., Williamson, M.S., Lewis, Lora R, Marcet-Houben, M, Solovyev, V., Duncan, EJ, Wolstenholme, A, Maglott, D, Guigó, R., Martinez-Torres, D, Rider, Stanley Dean, Duncan, E., Hansen, Karina K., Gerardo, Nicole M., Lozado, Ryan J., Morgan, Margaret B., Dale, RP, Price, Daniel R. G., Ermolaeva, Olga, Murphy, T, Hedges, Dale, Jiang, Huaiyang, Rispe, Claude, Chavez, D, Dale, R.P., Gauthier, J-P, Vieira, F.G., Heddi, Abdelaziz, Miyagishima, S.-Y., Martinez-Torres, David, Kaloshian, I, Nikoh, Naruo, Stanke, Mario, International Aphid Genomics Consortium, Vos, Martin, De, Kiryutin, B., Lozado, RJ, Davies, T. G. Emyr, Field, L.M., Ferrier, David, Dinh, Huyen H, Legeai, F., Jhangian, Shalini N., Wright, R.A., Fitzroy, CIJ, Hume, J., Ren, Q, de Vos, M, Wilkinson, TL, Ortiz-Rivas, B., Carolan, JC, Walsh, TK, McCutcheon, John P., Pruitt, K, Pruitt, Kim, Okwuonu, Geoffrey O, Caillaud, M, Heckel, D., Bickel, R.D., Thomas, G, Chen, Hsiu Chuan, Ghanim, M, Gabisi, Ramatu Ayiesha, Ashton, Peter D, Fenton, B, Robertson, Hugh M., Heckel, DG, Sagot, Marie France, Burke, G., Colella, S, Jones, A., Tamarit, D., Gordon, K, Atamian, H, Altincicek, B., Thibaud-Nissen, F., Koga, R., Duncan, Elizabeth, van Fleet, Eric, Anselme, Caroline, Williams, Rex L., Hansen, KK, Joshi, Vandita, Patel, B.M., Fitzroy, C.I.J., Brault, Veronique, Williamson, Martin S., Rizk, Guillaume, Kushlan, Philip F, Ramsey, J, Latorre, A., Pu, L.-L., Camara, Francisco, Butts, T., Liu, Y.-S., Williamson, MS, Cottret, Ludovic, Price, DRG, Smith, J, Burke, Gaelen, Zhou, Jing Jiang, Cazzamali, G., Reardon, Karen T, Hansen, K.K., Alioto, T., Cazzamali, Giuseppe, Abdel-latief, Mohatmed, Wilson, M., Permal, E., Williamson, M., Wilson, A.C.C., Janssen, R., Hines, Sandra, Stafflinger, Elisabeth, Hunter, W., Permal, E, Nazareth, L.V., McCutcheon, John P, Moran, Nancy A, Brault, V., Velarde, R, Chavez, D., Fenton, B., Lozado, R.J., Llorens, Carlos, Jones, DH, Dang, Phat M, Ashton, PD, Nazareth, Lynne V, McGregor, A, Jones, Andrew, Williamson, S, Dao, Marvin Diep, Gauthier, J.-P., Lavenier, D., Dearden, Peter, Price, Daniel R G, Pu, Ling-Ling, Nguyen, Ngoc Bich, Ashton, P., Nicolas, Jacques, Jones, A, Rizk, G., Williamson, M, Thomas, Gavin, Morgan, MB, Edwards, Owain R., Channels, Ion, Campbell, P., Huybrechts, J, Reeck, GR, Jhangian, SN, Vattathil, S, Kosarev, P, Williamson, S., Morgan, M.B., Perez-Brocal, Vicente, Christiaens, O., Huang, W., Hedges, D., Jhangian, S.N., Moen, C, Hurwitz, B, Reeck, G.R., Permal, Emmanuelle, Spragg, Chelsea J., Llorens, C., Kapustin, Y, Pu, L-L, Gabaldon, T, Davis, GK, Grimmelikhuijzen, Cornelis J. P., Vieira, Filipe G., Gerardo, N.M., Gordon, Karl, Brisson, Jennifer A., Williamson, Sally, Charles, H, Seah, S, Zhang, Lan, Fowler, Gerald R., Hitchens, ME, Zee, Maurijn, Van Der, Srinivasan, D., Chavez, Dean, Douglas, A, Ruiz, San Juana, Liu, R, Kapustin, Y., Santibanez, J, Jr, RSD, Walsh, Thomas K, Willson, Alex C.C., Dao, M.D., Huang, Wenting, Edwards, OR, Chang, C.-C., Lewis, L.R., van der Zee, M, Douglas, A.E., McCutcheon, JP, Wilkinson, Thomas L., Parker, B.J., Lu, H-L, Murphy, T., Stanke, M., Kitts, P, Jander, G., Zhang, L, Rider, Stanley Dean, Jr., Zhang, J, Mariotti, M, Bell, S.N., Marcet-Houben, Marina, Dearden, P, Duncan, E.J., Chen, Hsiu-Chuan, Macdonald, Sandy, Janssen, R, Fukatsu, Takema, Gibbs, Richard A, Worley, K.C., Reeck, Gerald R., Rispe, C, Dao, MD, Diaz, J., Stern, David, Moya, Andres, Febvay, Gerard, Shigenobu, S, Okwuonu, GO, Macdonald, S, Reardon, KT, van Fleet, E, Shigenobu, Shuji, Cortés, T., Legeai, Fabrice, Latorre, Amparo, Atamian, Hagop, Ramsey, John, Fukatsu, T, Steffen, David, Jones, Derek H., Bell, Stephanie N, Jones, Derek H, Spragg, Chelsea J, He, Xiao Li, Richards, S., Huang, W, Gabaldón, T., Velarde, Rodrigo, Sagot, Marie-France, Tagu, D., Quesneville, H, Veenstra, JA, Miura, Toru, Febvay, G., Janssen, Ralf, Nicolas, J, Johnson, A.J., Butts, T, Ferrier, D., Febvay, G, Jhangian, Shalini N, Nakabachi, A, Hauser, F., Kamphuis, Lars G, Vellozo, A., Cass, B., Bell, Stephanie N., Hunter, Wayne, Vilcinskas, Andreas, He, X.-L., Santibanez, J., Int Aphid Genomics Consortium, Rozas Liras, Julio A., McGregor, Alistair, Kitts, Paul, Calevro, F., Ju, H.-J., Chang, Chun Che, Latorre, A, Field, L. M., Smadja, C., Dearden, P., Moran, Nancy A., Grimmelikhuijzen, Cornelis J.P., Aguilar, J., Bickel, Ryan D., Lewis, LR, Kudo, T, Hurwitz, Bonnie, Wright, Rita A, Duncan, Elizabeth J., Zhou, J.-J., Alioto, Tyler, Smagghe, Guy, Collin, O, Kushlan, Philip F., Ortiz-Rivas, B, Anselme, C., Abdel-latief, M, Kiryutin, Boris, Rahbe, Y, Robichon, A., Colella, Stefano, Iga, M., Gibbs, R.A., Okwuonu, Geoffrey O., Huybrechts, J., Hines, S, Hitchens, M.E., Veenstra, J.A., Heddi, A., Nguyen, N.B., Ashton, P, Chang, C-C, , International Aphid Genomics Consortium, Okwuonu, G.O., Kovar, Christie, Barribeau, Seth, Wolstenholme, A., Kosarev, Peter, Davis, Clay, Tagu, D, Tamborindeguy, C., Liu, Yih-shin, Wilson, Alex C.C., Fleet, Eric, Van, Sapojnikov, V., Jaubert-Possamai, Stephanie, Zhou, J-J., Sattelle, David, Hunnicutt, L, Nakabachi, Atsushi, Dombrovsky, Aviv, Tamarit, Daniel, Ollivier, M, Monsion, B., Quesneville, Hadi, Nguyen, NB, Murphy, Terence, Koga, R, Dinh, Huyen H., Ren, Qinghu, Rahbé, Y., Reeck, Gerald, Cree, A., Diaz, Jason, Pignatelli, Miguel, Dang, PM, Gibbs, RA, Ferrier, D, Spragg, C.J., Edwards, O.R., Wilson, Alex C C, Ramsey, J., Degnan, Patrick, Sapojnikov, Victor, Jaubert, Stéphanie, Gibbs, Richard A., Nazareth, Lynne V., Hume, Jennifer, Srinivasan, D, Bickel, RD, Calevro, Federica, Guigo, Roderic, Richards, Stephen, Pu, Ling Ling, Smadja, C, Campbell, P, Chandrabose, Mimi N., Brisson, Jennifer A, Grimmelikhuijzen, Cornelis JP, Tamames, J, Lavenier, Dominique, Morgan, Margaret B, Rider Jr., Stanley Dean, Ashton, Peter, Davis, C, Chang, Chun-che, Smadja, Carole, Warren, J.T., Cottret, L., Gatehouse, JA, Guigo, R, Solovyev, Victor, Robichon, A, Jander, Georg, Robichon, Alain, Heddi, A, Calevro, F, Mariotti, Marco, Vincent-Monegat, C., Gerado, N., Aguilar, Jose, Consortium, IAG, Worley, Kim C., Williams, Rex L Jr, Janssen, Ralf,, Lee, S.L., Walsh, Thomas K., Ruiz, SJ, Kamphuis, LG, Kovar, C., Ishikawa, A., Iga, Masatoshi, Hlavina, Wratko, Kushlan, PF, Thibaud-Nissen, Francoise, Singh, K., Quesneville, H., Johnson, AJ, Spragg, CJ, He, X-L., De Vos, M., Duncan, E, Miyagishima, Shin Ya, Kudo, T., Lopez, J, Koga, Ryuichi, Warren, James T, Rozas, J., Liu, Renhu, Steffen, D, Souvorov, A, Nikoh, N., Rider, Stanley Dean Jr, Kovar, C, Liu, R., Vincent-Monegat, C, Field, LM, Vattathil, S., Wright, RA, Kamins, Alexandra, Fowler, G.R., Llorens, C, Evans, J., Lu, Hsiao Ling, Edwards, Owain R, Veenstra, Jan A, Ju, H-J, Ghanim, M., Worley, KC, Warren, James T., Wolstenholme, Adrian, Stern, D, Jander, G, Sapojnikov, V, Ruiz, S.J., Nicolas, J., Warren, JT, Williams, Rex L., Jr., Marcet-Houben, M., Williams, Rex L, Grimmelikhuijzen, CJP, Schwartz, J, Bell, SN, Caillaud, M., Sagot, M.F., Vellozo, Augusto, Burke, G, Fitzroy, Carol IJ, Abdel-Latief, M., Zhang, J., Rizk, G, Douglas, Angela E., Dale, Richard P., Fukatsu, T., Perez-Brocal, V, Van Fleet, E., Davies, T.G.E., Seah, Stuart, Gatehouse, J. A., Ferrier, David Ellard Keith, Grimmelikhuijzen, Cornelis J P, McCutcheon, J.P., The International Aphid Genomics Consortium, Iagc, Carolan, James C., Gerardo, Nichole M., Gibbs , R., Sattelle, D, Pignatelli, M., Solovyev, V, Lee, Sandra L, Kitts, P., Davis, C., Steffen, D., Zhang, L., Cazzamali, G, Tamarit, D, Ju, Ho Jong, Thibaud-Nissen, F, Liu, Yih Shin, Shigenobu, S., Reardon, K.T., Moran, Nancy, Moran, NA, Stern, D., Barribeau, SM, Souvorov, A., Rider Jr., S.D., Vieira, FG, Gatehouse, J.A., Cottret, L, McGregor, A., Chandrabose, MN, He, Xiao-Li, Hauser, Frank, Worley, Kim C, Hilgarth, Roland S, Maglott, D., Pignatelli, M, Moran, N, Gilbert, D., Brisson, JA, Wilkinson, Thomas L, Dombrovsky, A, Dale, Richard P, Futami, Ricardo, Ghanim, Murad, Tamames, Javier, Davis, Gregory K, Patel, Bella Mayurkumar, Fitzroy, Carol I J, Moran, N., Martínez-Torres, D., Lavenier, D, Williamson, M. S., Rozas, J, Lopez, J., Leonardo, T, Altincicek, Boran, Charles, H., Degnan, P., Lopez, John, Douglas, Angela E, Johnson, Angela Jolivet, Williams, RL, Rider, SD, Guigó Serra, Roderic, null null, Richards, Stephan +783 morecore +1 more sourceMagneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia
Advanced Science, EarlyView.Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu +6 morewiley +1 more sourceA G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome
Journal of Biomedical ScienceBackground G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) genome.Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard, Tao Jia +15 moredoaj +1 more sourceGlutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors
Advanced Science, EarlyView.An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu +10 morewiley +1 more source
