Results 101 to 110 of about 921,496 (243)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Presentazione del libro "Filosofia, mito y fascismo. Releyendo "El mito del Estado" de Ernst Cassirer" (RAGIF Ediciones)

, 2020
Presentazione del libro "Filosofia, mito y fascismo.
ciaramelli
core  

O mito da subalternidade do trabalho da enfermagem a medicina [PDF]

, 1998
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciencias da SaudeA partir da suposta existência de um mito que confere subalternidade do trabalho da enfermagem à medicina, foi realizada uma pesquisa, por meio da observação das ...
LUNARDI FILHO, Wilson Danilo
core  

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

The genome of Phlebotomus chinensis, the primary vector of visceral leishmaniasis in China: insights from chromosome-level assembly and comparative analysis

Infectious Diseases of Poverty
Background Phlebotomus chinensis is the primary vector of visceral leishmaniasis (VL) in China. However, the lack of a high-quality genome assembly for this species has limited research on its biology, vector-pathogen interactions, and evolutionary ...
Haowei Dong, Wenqi Shan, Qiuming Zhou, Hao Yuan, Kang Wang, Yuanyuan Li, Wenbing Zhong, Maimaitijiang Wumaier, Anjie Yang, Huiying Chen, Bing Rui, Yajun Ma, Shizhu Li, Heng Peng   +13 more
doaj   +1 more source

Orpheus and Eurydice: Metamorphosis of a Myth between Literature and Figurative Art

, 2023
reservedL'oggetto di studio è il mito di Orfeo ed Euridice. Un primo livello di analisi si concentra sulla nozione di mito da un punto di vista teorico, per poi procedere con l'osservazione degli elementi diegetici e tematici della storia.
TARTAGLIA, LETIZIA
core  

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Mitochondrial genome of the North American Morus rubra L. (red mulberry) reveals plastome gene transfer and essence of RNA editing

Discover Plants
Morus rubra L. (Family: Moraceae), native to eastern North America, is distributed in the heart of pristine riparian forests and holds important ethnobotanical and ecological values.
Bibek Adhikari, Emily Ringgenberg, Gavin Smith, Ryan Johnson, Sanam Parajuli, Jeffrey D. Carstens, Madhav P. Nepal   +6 more
doaj   +1 more source

Current perspectives on circadian regulation of mitochondrial dynamics in mood disorders and perioperative stress

Frontiers in Pharmacology
Mitochondria act as a central integrative hub for oxidative phosphorylation, calcium homeostasis and metabolic signaling, reflecting their evolutionary origin from an α-proteobacterial endosymbiont.
Florencia Verbal, Florencia Verbal, Nicole Rubilar, Nicole Rubilar, Ana M Marileo, Humberto Fierro, Oscar Guillermo Ramirez-Molina, Araceli Pinto-Leon, Gonzalo E Yevénes, Jorge Fuentealba, Jorge Fuentealba, Jessica Panes-Fernández, Jessica Panes-Fernández   +12 more
doaj   +1 more source