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Chemical Reviews, 2017 Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic
Jacek Zielonka +2 more
exaly +2 more sources
Blood contains circulating cell‐free respiratory competent mitochondria
FASEB Journal, 2020 Mitochondria are considered as the power‐generating units of the cell due to their key role in energy metabolism and cell signaling. However, mitochondrial components could be found in the extracellular space, as fragments or encapsulated in vesicles. In
Brice Pastor +2 more
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Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism
Frontiers in Immunology, 2018 Lack of immune system cells or impairment in differentiation of immune cells is the basis for many chronic diseases. Metabolic changes could be the root cause for this immune cell impairment.
Clayton C Yates, Zongbing You, Ming Tan
exaly +2 more sources
Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
Nature, 2018 Yvette C Wong +2 more
exaly +2 more sources
Separations, 2023 Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and ...
Jiwei Yang +10 more
doaj +1 more source
Foods, 2022 Histidine (His) carries a unique heteroaromatic imidazole side chain and plays an irreplaceable role in peptides and proteins. With the current study, we aimed to determine the characteristics and functional activities of the bone density of soy peptide ...
Jing Gan +8 more
doaj +1 more source
The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin
Molecules, 2023 Thymopentin (TP5) has exhibited strong antitumor and immunomodulatory effects in vivo. However, the polypeptide is rapidly degraded by protease and aminopeptidase within a minute at the N-terminal of TP5, resulting in severe limitations for further ...
Haiyu Ji +7 more
doaj +1 more source
Frontiers in Nutrition, 2023 IntroductionAnalysis of the composition of yogurt alternatives (YAs) during fermentation provides critical information for evaluating its quality and nutritional attributes.MethodWe investigated the effects of homotypic (HO) and heterotypic (HE) lactic ...
Jing Gan +11 more
doaj +1 more source
Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution [PDF]
, 2018 Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors.
Bova, Sergio +5 more
core +8 more sources
Biology Direct, 2022 Background In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al.
Nicolò Ilacqua +9 more
doaj +1 more source