Results 1 to 10 of about 704,274 (355)

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Chemical Reviews, 2017
Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic
Jacek Zielonka, Adam Sikora, Micael Hardy   +2 more
exaly   +2 more sources

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

Nature, 2018
Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and dysfunction of both organelles has been observed in multiple diseases.
Yvette C Wong, Daniel Ysselstein, Dimitri Krainc   +2 more
exaly   +2 more sources

Blood contains circulating cell‐free respiratory competent mitochondria

FASEB Journal, 2020
Mitochondria are considered as the power‐generating units of the cell due to their key role in energy metabolism and cell signaling. However, mitochondrial components could be found in the extracellular space, as fragments or encapsulated in vesicles. In
Brice Pastor, Giuseppe Arena, Thierry Grange   +2 more
exaly   +2 more sources

Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

Separations, 2023
Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and ...
Jiwei Yang, Zhi Yan, Lingna Li, Lifen Zhang, Mengjian Zhao, Huixiang Yi, Ziying Wang, Gang Li, Zhenhua Wang, Mei Li, Chengjun Ma   +10 more
doaj   +1 more source

Calcium Binding Mechanism of Soybean Peptide with Histidine Alteration by Molecular Docking Analysis and Spectroscopic Methods

Foods, 2022
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays an irreplaceable role in peptides and proteins. With the current study, we aimed to determine the characteristics and functional activities of the bone density of soy peptide ...
Jing Gan, Xiao Kong, Ziqun Xiao, Yuhang Chen, Mengdi Du, Yan Wang, Zhenhua Wang, Yongqiang Cheng, Bo Xu   +8 more
doaj   +1 more source

Mitochondria metabolism sets the species-specific tempo of neuronal development

Science, 2023
Neuronal development in the human cerebral cortex is considerably prolonged compared with that of other mammals. We explored whether mitochondria influence the species-specific timing of cortical neuron maturation.
Ryohei Iwata, P. Casimir, Emir Erkol, Leila Boubakar, M. Planque, Isabel M. Gallego López, Martyna Ditkowska, Vaiva Gaspariunaite, Sofie Beckers, Daan Remans, K. Vints, A. Vandekeere, S. Poovathingal, M. Bird, Ine Vlaeminck, Eline Creemers, Keimpe D. Wierda, Nikky Corthout, P. Vermeersch, S. Carpentier, K. Davie, M. Mazzone, Natalia V. Gounko, S. Aerts, B. Ghesquière, S. Fendt, P. Vanderhaeghen   +26 more
semanticscholar   +1 more source

The Protective Effects of Water-Soluble Alginic Acid on the N-Terminal of Thymopentin

Molecules, 2023
Thymopentin (TP5) has exhibited strong antitumor and immunomodulatory effects in vivo. However, the polypeptide is rapidly degraded by protease and aminopeptidase within a minute at the N-terminal of TP5, resulting in severe limitations for further ...
Haiyu Ji, Yuting Fan, Xiaoji Gao, Youshun Gong, Keyao Dai, Zhenhua Wang, Bo Xu, Juan Yu   +7 more
doaj   +1 more source

Effect of fermentation using different lactic acid bacteria strains on the nutrient components and mineral bioavailability of soybean yogurt alternative

Frontiers in Nutrition, 2023
IntroductionAnalysis of the composition of yogurt alternatives (YAs) during fermentation provides critical information for evaluating its quality and nutritional attributes.MethodWe investigated the effects of homotypic (HO) and heterotypic (HE) lactic ...
Jing Gan, Xiao Kong, Kuaitian Wang, Kuaitian Wang, Yuhang Chen, Yuhang Chen, Mengdi Du, Bo Xu, Jingru Xu, Zhenhua Wang, Yongqiang Cheng, Tianying Yu   +11 more
doaj   +1 more source

Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis

Biology Direct, 2022
Background In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al.
Nicolò Ilacqua, Irene Anastasia, Danylo Aloshyn, Rana Ghandehari-Alavijeh, Emily Ann Peluso, Madelaine C. Brearley-Sholto, Leonardo V. Pellegrini, Andrea Raimondi, Thomas Q. de Aguiar Vallim, Luca Pellegrini   +9 more
doaj   +1 more source

The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics

Biomedicines, 2022
Mitochondria are intracellular organelles that utilize nutrients to generate energy in the form of ATP by oxidative phosphorylation. Mitochondrial DNA (mtDNA) in humans is a 16,569 base pair double-stranded circular DNA that encodes for 13 vital proteins
Sanjana Saravanan, Caitlin J. Lewis, Bhavna Dixit, Matthew S. O’Connor, Alexandra Stolzing, Amutha Boominathan   +5 more
doaj   +1 more source