Results 1 to 10 of about 240,768 (310)

Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases

Frontiers in Cardiovascular Medicine, 2021
Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu, Xianjing Song, Youyou Yan, Bin Liu   +3 more
doaj   +1 more source

The Effect of Astaxanthin on Mitochondrial Dynamics in Rat Heart Mitochondria under ISO-Induced Injury

Antioxidants, 2023
Mitochondria are dynamic organelles that produce ATP in the cell and are sensitive to oxidative damage that impairs mitochondrial function in pathological conditions.
Roman Krestinin, Yulia Baburina, Irina Odinokova, Alexey Kruglov, Linda Sotnikova, Olga Krestinina   +5 more
doaj   +1 more source

Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger

Cells, 2021
Cardiovascular diseases are one of the leading causes of death and global health problems worldwide, and ischemic heart disease is the most common cause of heart failure (HF). The heart is a high-energy demanding organ, and myocardial energy reserves are
Justin D. Yu, Shigeki Miyamoto
doaj   +1 more source

Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection. [PDF]

PLoS ONE, 2016
We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile function.
Douglas B Cowan, Rouan Yao, Vamsidhar Akurathi, Erin R Snay, Jerusha K Thedsanamoorthy, David Zurakowski, Maria Ericsson, Ingeborg Friehs, Yaotang Wu, Sidney Levitsky, Pedro J Del Nido, Alan B Packard, James D McCully   +12 more
doaj   +1 more source

New Insights Into the Role of Mitochondria Quality Control in Ischemic Heart Disease

Frontiers in Cardiovascular Medicine, 2021
IHD is a significant cause of mortality and morbidity worldwide. In the acute phase, it's demonstrated as myocardial infarction and ischemia-reperfusion injury, while in the chronic stage, the ischemic heart is mainly characterised by adverse myocardial ...
Yanguo Xin, Xiaodong Zhang, Xiaodong Zhang, Jingye Li, Hui Gao, Jiayu Li, Junli Li, Wenyu Hu, Hongwei Li, Hongwei Li, Hongwei Li   +10 more
doaj   +1 more source

Differences in mitochondrial function between brain and heart of senile rats exposed to acute hypobaric hypoxia. Role of nitric oxide

Experimental Gerontology, 2023
Rat brain and heart display different endogenous protective responses against hypobaric hypoxia in an age-dependent way. The aim of the present work was to evaluate the effects of acute hypobaric hypoxia (HH, 48 h) on brain and heart mitochondrial ...
P. La Padula, L.E. Costa, A. Karadayian, S. Lores-Arnaiz, A. Czerniczyniec   +4 more
doaj   +1 more source

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice

Biomedicines, 2021
Supporting mitochondrial function is one of the therapeutic strategies that improve the functioning of skeletal muscle in Duchenne muscular dystrophy (DMD).
Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Dmitriy A. Serov, Kirill S. Tenkov, Evgeniya V. Belosludtseva, Konstantin N. Belosludtsev   +8 more
doaj   +1 more source

Mitochondrial mechanosensor in cardiovascular diseases

Vascular Biology, 2020
The role of mitochondria in cardiac tissue is of utmost importance due to the dynamic nature of the heart and its energetic demands, necessary to assure its proper beating function.
Cristina Caffarra Malvezzi, Aderville Cabassi, Michele Miragoli   +2 more
doaj   +1 more source

Substrate- and Calcium-Dependent Differential Regulation of Mitochondrial Oxidative Phosphorylation and Energy Production in the Heart and Kidney

Cells, 2021
Mitochondrial dehydrogenases are differentially stimulated by Ca2+. Ca2+ has also diverse regulatory effects on mitochondrial transporters and other enzymes. However, the consequences of these regulatory effects on mitochondrial oxidative phosphorylation
Xiao Zhang, Namrata Tomar, Sunil M. Kandel, Said H. Audi, Allen W. Cowley, Ranjan K. Dash   +5 more
doaj   +1 more source

Transport of Ca²⁺ and Ca²⁺-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia

Biomolecules, 2020
The work examines the kinetic parameters of Ca2+ uptake via the mitochondrial calcium uniporter complex (MCUC) and the opening of the Ca2+-dependent permeability transition pore (MPT pore) in the liver and heart mitochondria of rats with high resistance (
Konstantin N. Belosludtsev, Mikhail V. Dubinin, Eugeny Yu. Talanov, Vlada S. Starinets, Kirill S. Tenkov, Nadezhda M. Zakharova, Natalia V. Belosludtseva   +6 more
doaj   +1 more source