Results 11 to 20 of about 240,768 (310)
Mitochondria in heart failure [PDF]
Cardiovascular Research, 2010 This review focuses on the evidence accumulated in humans and animal models to the effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria are the primary source of energy in the form of adenosine triphosphate that fuels the contractile apparatus, and are thus essential for the pumping activity of the heart.
Mariana G, Rosca, Charles L, Hoppel
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Mitochondria in the diabetic heart [PDF]
Cardiovascular Research, 2010 Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension.
Bugger, Heiko, Abel, Evan Dale
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Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography [PDF]
, 2017 The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria-junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable
Cabrera-Fuentes, Hector +12 more
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CaMKII and stress mix it up in mitochondria
Frontiers in Pharmacology, 2014 CaMKII is a newly discovered resident of mitochondria in the heart. Mitochondrial CaMKII promotes poor outcomes after heart injury from a number of pathological conditions, including myocardial infarction, ischemia reperfusion and stress from ...
Olha M Koval, Mei-ling A Joiner
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Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease
Cell Death and Disease, 2022 Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis.
Anqi Li +7 more
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Viruses, 2023 The myocardium/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume.
Yasir Mohamud +3 more
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Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage : meeting abstract [PDF]
, 2009 Mitochondria are essential for respiration and oxidative phosphorylation. Mitochondrial dysfunction due to aging processes is involved in pathologies and pathogenesis of a series of cardiovascular disorders. New results accumulate showing that the enzyme
Altschmied, Joachim +5 more
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Lipid composition of mitochondria from bovine heart, liver, and kidney
Journal of Lipid Research, 1967 Highly purified preparations of mitochondria from bovine heart, liver, and kidney were isolated and characterized by electron microscopy, oxidative phosphorylation ability, cytochrome c reductase activity, and cytochrome content.
Sidney Fleischer +4 more
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Proteolytic Processing of OPA1 Links Mitochondrial Dysfunction to Alterations in Mitochondrial Morphology [PDF]
, 2006 Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in mitochondrial morphology.
Attardi, Giuseppe +11 more
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Mitochondria in the human heart [PDF]
Journal of Bioenergetics and Biomembranes, 2009 The heart relies mainly on mitochondrial metabolism to provide the energy needed for pumping blood to oxygenate the organs of the body. The study of mitochondrial function in the human heart faces many obstacles and elucidation of the role of mitochondria in cardiac diseases has relied mainly on studies with animal models.
Lemieux, H., Hoppel, C. L.
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