Results 271 to 280 of about 240,768 (310)
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Malate transport into heart mitochondria
Journal of Molecular and Cellular Cardiology, 1975Abstract The oxidation of l -Malate to carbon dioxide was employed as a measure of malate transport into mitochondria. Conditions of incubation were optimized with regard to osmolarity, pH, phosphate concentration, and substrate concentrations.
S B, Digerness, W J, Reddy
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Subpopulations of human heart mitochondria
Journal of Surgical Research, 1986Anatomically and biochemically distinct populations of cardiac mitochondria have been isolated from a number of animal species. The physiologic differences between subsarcolemmal (SS) and interfibrillar (IF) mitochondria, coupled with their different location within the cytomatrix, have led to speculation about possible specificities of function within
E S, Weinstein, D W, Benson, D E, Fry
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Mitochondria and Heart Disease
2011Mitochondria play a key role in the normal functioning of the heart, and in the pathogenesis and development of various types of heart disease. Physiologically, mitochondrial ATP supply needs to be matched to the often sudden changes in ATP demand of the heart, and this is mediated to a large extent by the mitochondrial Ca(2+) transport pathways ...
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Mitochondria in heart ischaemia and aging
Biochemical Society Symposia, 1999We have examined the effect of dietary polyunsaturated fatty acids (PUFAs) upon mitochondrial Ca2+ content and dehydrogenase activation in the rat heart. Diets were either a conventional low-fat chow (Ref) or were rich in n-3 PUFAs from fish oils (n-3) or n-6 PUFAs from animal fat (n-6).
R G, Hansford, N, Tsuchiya, S, Pepe
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Mitochondria in Ischemic Heart Disease
2017A core feature of ischemic heart disease is injury to cardiomyocytes (CMC). Ischemic CMC manifest the molecular mechanisms to undergo the major forms of cell injury and death, namely, oncotic necrosis, necroptosis, apoptosis and unregulated autophagy. Important modulators of ischemic injury are reperfusion and conditioning.
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Breaking mitochondria and hearts
Science, 2018Cardiac Dysfunction Blocking the excessive mitochondrial fission mediated by dynamin-related protein 1 (Drp1) that occurs after myocardial infarction prevents cardiac dysfunction from developing. Nishimura et al. found that the cytoskeletal regulator filamin increased Drp1 activity after myocardial infarction and that the filamin-Drp1 interaction was ...
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Fumarate permeation in rat heart mitochondria
Biochemical and Biophysical Research Communications, 1979Abstract The possible fumarate translocation in rat heart mitochondria is examined. This substrate, which is claimed to be a non permeant ion in rat liver mitochondria appears to cross the mitochondrial membrane in cardiac mitochondria. This conclusion was proposed on the basis of experimental results which show swelling by rat heart mitochondria in ...
S, Passarella +3 more
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Giant Mitochondria in a Cardiomyopathic Heart
Ultrastructural Pathology, 2002Giant mitochondria (megamitochondria) measuring up to 14 microm in length and 3 microm in width are sporadically present in an exclusively interfibrillar position in the cardiomyocytes of a patient with restrictive cardiomyopathy. The number of cristae is augmented in the megamitochondria; these internal membranes are for the most part irregularly ...
Bernard, Tandler +3 more
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Mitochondria and heart disease.
Current opinion in cardiology, 1998Because the myocardium depends heavily on oxidative metabolism, it is not surprising that genetic errors of mitochondrial function often result in cardiomyopathies. The emphasis of this review is on disorders of the respiratory chain, the only area of cell metabolism that is under dual genetic control: 1) the mitochondrial genome (mtDNA) encodes 13 ...
S, DiMauro, M, Hirano
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A change of heart (mitochondria)
Science, 2015Mitochondrial dynamics play key roles in heart development and cardiomyocyte health.
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