Results 21 to 30 of about 240,768 (310)

D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

Nutrition & Metabolism, 2012
Background Substantially elevated blood D-lactate (DLA) concentrations are associated with neurocardiac toxicity in humans and animals. The neurological symptoms are similar to inherited or acquired abnormalities of pyruvate metabolism.
Ling Binbing, Peng Fei, Alcorn Jane, Lohmann Katharina, Bandy Brian, Zello Gordon A   +5 more
doaj   +1 more source

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. [PDF]

, 2016
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis.
Jiao, Kun, Lau, Wayne Bond, Liu, Huirong, Liu, Xin, Ma, Lu, Ma, Xinliang, Shang, Jianyu, Wang, Ke, Wang, Wen, Wang, Xiaoliang, Yuan, Yuexing, Zuo, Lin   +11 more
core   +2 more sources

Anion translocators in rat‐heart mitochondria [PDF]

FEBS Letters, 1971
At least seven different anion translocators have been demonstrated in rat liver mitochondria [ 1,2] . These translocators may be distinguished from each other by their specificity for substrates and their differential sensitivity to inhibitors [3] . Most anions enter the mitochondria in exchange for internal anions [4] (for a review, see [2]).
Sluse, Francis E., Meijer, Alfred J., Tager, Joseph M.   +2 more
openaire   +3 more sources

Mitochondria as Therapeutic Targets in Heart Failure [PDF]

Current Heart Failure Reports, 2022
Abstract Purpose of Review We review therapeutic approaches aimed at restoring function of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling, and substrate utilization for adenosine triphosphate (ATP) production.
Schwemmlein, Julia, Maack, Christoph, Bertero, Edoardo   +2 more
openaire   +3 more sources

Mitochondria and the aging heart. [PDF]

Journal of geriatric cardiology : JGC, 2011
The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual.
Chaudhary, Ketul R, El-Sikhry, Haitham, Seubert, John M   +2 more
openaire   +3 more sources

Changes in the respiratory function of the heart and brain mitochondria of animals after chronic alcohol intoxication affected by a new GABA derivative [PDF]

Research Results in Pharmacology, 2021
Introduction: Chronic ethanol consumption leads to significant functional and structural changes in the mitochondria of the heart and brain, increasing generation of reactive oxygen species.
Tamara A. Popova, Margarita V. Kustova, Gulnara Kh. Khusainova, Valentina N. Perfilova, Igor I. Prokofiev, Yulia A. Smolnyakova, Ludmila E. Borodkina, Ivan N. Tyurenkov, Oleg V. Ostrovskiy, Olga S. Vasil’eva   +9 more
doaj   +3 more sources

Mitochondria and heart failure

Current Opinion in Clinical Nutrition and Metabolic Care, 2007
Energetic abnormalities in cardiac and skeletal muscle occur in heart failure and correlate with clinical symptoms and mortality. It is likely that the cellular mechanism leading to energetic failure involves mitochondrial dysfunction. Therefore, it is crucial to elucidate the causes of mitochondrial myopathy, in order to improve cardiac and skeletal ...
Murray, Andrew J, Edwards, Lindsay M, Clarke, Kieran   +2 more
openaire   +4 more sources

The effect of Tmem135 overexpression on the mouse heart. [PDF]

PLoS ONE, 2018
Tissues with high-energy demand including the heart are rich in the energy-producing organelles, mitochondria, and sensitive to mitochondrial dysfunction. While alterations in mitochondrial function are increasingly recognized in cardiovascular diseases,
Sarah Aileen Lewis, Tetsuya Takimoto, Shima Mehrvar, Hitoshi Higuchi, Anna-Lisa Doebley, Giangela Stokes, Nader Sheibani, Sakae Ikeda, Mahsa Ranji, Akihiro Ikeda   +9 more
doaj   +1 more source

Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

Biomedicines, 2023
Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for various physiological activities of the cell. Cardiomyocytes have a high density of mitochondria and mitochondrial damage is present in a variety of ...
Yafei Huang, Bingying Zhou
doaj   +1 more source

Influence of a B16/F10 melanoma variant on the Вcl-2 levels in mitochondria in various organs of female mice

Бюллетень сибирской медицины, 2021
Aim. To study the Bcl-2 level in mitochondria of various organs in female mice with standard and stimulated growth of an experimental B16/F10 melanoma.Materials and methods. The study included С57ВL/6 female mice (n = 168).
O. I. Kit, E. M. Frantsiyants, I. V. Neskubina, N. D. Cheryarina, A. I. Shikhlyarova, E. I. Surikova, I. V. Kaplieva, L. A. Nemashkalova   +7 more
doaj   +1 more source