Results 201 to 210 of about 2,143,132 (361)

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Regulatory role of sirtuin-1 by targeting MDM2 to mitochondria-associated membranes formation in the treatment of NAFLD. [PDF]

Cell Commun Signal
Zhang R, Zhang Q, Cui Z, Huang B, Li M, Ma H.   +5 more
europepmc   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Iron-related intercellular communication in the liver: Main players and mechanisms. [PDF]

Eur J Clin Invest
Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.   +4 more
europepmc   +1 more source

Demethyleneberberine, a Natural Mitochondria-Targeted Antioxidant, Inhibits Mitochondrial Dysfunction, Oxidative Stress, and Steatosis in Alcoholic Liver Disease Mouse Model

Journal of Pharmacology and Experimental Therapeutics, 2015
P. Zhang, Xiaoyan Qiang, Miao Zhang, Dongshen Ma, Zheng-Xiao Zhao, Cuisong Zhou, Xie Liu, Ruiyan Li, Huan Chen, Yubin Zhang   +9 more
semanticscholar   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Protective role of hydroalcoholic extract of Medusomyces gisevii L. in non-alcoholic fatty liver disease: insights from a murine model. [PDF]

Res Pharm Sci
Gashti RZ, Karami M, Habibi E, Abbasi A, Parsay S, Modanloo M, Khalili HA, Shokrzadeh M.   +7 more
europepmc   +1 more source

Mechanistic approach for the toxic effects of perfluorooctanoic acid on isolated rat liver and brain mitochondria

Human and Experimental Toxicology, 2015
Vida Mashayekhi, K. Tehrani, M. Hashemzaei, K. Tabrizian, J. Shahraki, M. Hosseini   +5 more
semanticscholar   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Morphological alterations of peridroplet mitochondria in human liver biopsy. [PDF]

Sci Rep
Kawecka H, Imai N, Ohsaki Y, Cheng J, Liu D, Zhang J, Mizuno F, Tanaka T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishikawa T, Woźniak M, Wake H, Kawashima H.   +16 more
europepmc   +1 more source