Results 181 to 190 of about 177,404 (269)

Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model. [PDF]

J Clin Invest
Morigny P, Ji H, Cussonneau L, Zorzato S, Kwon Y, Riols F, Kaltenecker D, Maier A, Karthikaisamy V, Corrà S, Krauss T, Seeliger C, Gillani SQ, Tissink JJ, Lacas-Gervais S, Samanci TF, Maida A, Terron-Exposito R, Trinca A, von Toerne C, Nogara L, Claussnitzer M, Prokopchuk O, Bachmann J, Berriel Diaz M, Bindels LB, Kuda O, Hauner H, Haid M, Herzig S, Viscomi CF, Gilleron J, Zeigerer A, Blaauw B, Rohm M.   +34 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Mitochondrial Calcium Signaling in Hepatocyte Health and Disease. [PDF]

Cold Spring Harb Perspect Biol
Eberhardt DR, Chaudhuri D.
europepmc   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

Systemic delivery of AAV-GFM1 corrects COXPD1 molecular alterations in Gfm1^R671C/- mice. [PDF]

EMBO Mol Med
Molina-Berenguer M, Herrero-Martínez D, Vallbona-Garcia A, Vila-Julià F, Cámara Y, Vales Á, González-Aseguinolaza G, Torres-Torronteras J, Martí R.   +8 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Exercise Stimulates <i>PINK-1, PARKIN, MFN-1</i>, and <i>ATG-3</i> Genes Expression Despite High-fat Diet: Tissue-specific Responses. [PDF]

In Vivo
Durak S, Sezgin SBA, Celik F, Yilmazer Y, Cevik A, Kucukhuseyin O, Yaylim I, Zeybek U.   +7 more
europepmc   +1 more source

Conformational Transduction Amplification in a Biomimetic Polyelectrolyte for Ultrasensitive Imaging of Iron Metabolism

Advanced Science, EarlyView.
This work designs a peptide‐free polyelectrolyte with stable, switchable conformations and near‐infrared fluorescence in water. It harnesses a cooperative Fe3+‐triggered sheet‐to‐helix transition to generate nonlinear fluorescence quenching, enabling the ultrasensitive, real‐time visualization of Fe3+ ion distribution and metabolic trafficking at ...
Yeqiang Zhou, Danqi Yang, Yiwei Wang, Shuangyan Li, Fan Fan, Jiayu Zou, Cheng Zhang, Yang Liu, Hong Tan, Mingming Ding   +9 more
wiley   +1 more source

Preparation of Antioxidant Peptides Derived From Quinoa Protein and Evaluation of Their Antioxidant Activity Through a D-Galactose-Induced Aging Mice Model. [PDF]

Food Sci Nutr
Gao D, Zhang Y, Ma H.
europepmc   +1 more source