Results 171 to 180 of about 177,404 (269)

Pantothenic Acid Derivatives Modulate Oxidative Stress and Hepatic Fibrosis in Bile Duct Ligation-Induced Cholestatic Liver Injury. [PDF]

Pathophysiology
Semenovich DS, Abramicheva PA, Zorova LD, Elchaninov AV, Kozlova MA, Areshidze DA, Andrianova NV, Kanunnikova NP, Moiseenok AG, Pevzner IB, Plotnikov EY, Zorov DB.   +11 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Panthenol Protects Against Oxidative Stress and Liver Fibrosis in Cholestasis in Association with Increased Coenzyme A Biosynthesis. [PDF]

Int J Mol Sci
Semenovich DS, Abramicheva PA, Zorova LD, Elchaninov AV, Markova OV, Andrianova NV, Babenko VA, Kanunnikova NP, Moiseenok AG, Pevzner IB, Buyan MI, Plotnikov EY, Zorov DB.   +12 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Ginsenoside Rb1 alleviates overtraining-induced oxidative stress in mouse liver by stimulating mitophagy via Nrf2 pathway. [PDF]

Front Nutr
Lu J, Xu R, Gao Y, Zong L, Wang D, Li J.
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis. [PDF]

Chin Med
Yang X, Liang H, Li X, Tian J, Fan S, Huang M, Wan J, Zuo Z, Guo H, Bi H.   +9 more
europepmc   +1 more source

THE CARBOXYLATION OF PROPIONIC ACID BY LIVER MITOCHONDRIA

Journal of Biological Chemistry, 1956
F, FRIEDBERG, J, ADLER, H A, LARDY
openaire   +2 more sources

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source