Results 211 to 220 of about 2,143,132 (361)

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Adipose-derived mesenchymal stem cell therapy modulates mitochondrial function to attenuate acetaminophen-induced liver injury by DDIT4/PGC-1α axis. [PDF]

Stem Cell Res Ther
Cen Y, Xia C, Yao S, Weng X, Qi J, Lou G, Zheng M, Liu Y.   +7 more
europepmc   +1 more source

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Nature Protocols, 2007
C. Frezza, S. Cipolat, L. Scorrano
semanticscholar   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice. [PDF]

Toxicol Sci
Jain S, Williams G, Mukherjee R, Orr A, Liu JJ, Liu S, Locker J, Bhushan B.   +7 more
europepmc   +1 more source

Processing of mitochondrial precursor proteins [PDF]

, 1984
Neupert, Walter, Schmidt, Bernd
core  

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation. [PDF]

Aging Cell
Mitchell W, de Magalhães CG, Tyshkovskiy A, Uchida Y, Goeminne LJE, Ichimura T, Ng EL, Moldakozhayev A, Bonventre JV, Gladyshev VN.   +9 more
europepmc   +1 more source

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Drug metabolism reviews (Softcover ed.), 2012
H. Jaeschke, Mitchell R. McGill, A. Ramachandran   +2 more
semanticscholar   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source