Results 281 to 290 of about 496,331 (317)
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MITOCHONDRIA: Are mitochondria accessory to metastasis?
The International Journal of Biochemistry & Cell Biology, 2014Since the nineteenth century the importance of mitochondria in cellular physiology has been growing steadily. Not only the organelle harbors the main systems for ATP generation, but also buffers the redox potential in the cytosol and is one of the protagonists of the intrinsic pathway for apoptosis.
Nivea Dias Amoedo +2 more
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Cadmium and mitochondria [PDF]
Mitochondrion, 2009 The heavy metal cadmium (Cd) a pollutant associated with several modern industrial processes, is absorbed in significant quantities from cigarette smoke, water, food and air contaminations. It is known to have numerous undesirable effects on health in both experimental animals and humans, targeting kidney, liver and vascular system.
CANNINO, Giuseppe +3 more
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Mitochondria and cardioprotection
Heart Failure Reviews, 2007Major factors linking mitochondrial dysfunction with myocardial injury are analyzed along with protective mechanisms elicited by endogenous processes and pharmacological treatments. In particular, a reduced rate of ATP hydrolysis and a slight increase in ROS formation appear to represent the prevailing components of self-defense mechanisms, especially ...
DI LISA, FABIO +4 more
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Anthracyclines and Mitochondria
2011Anthracyclines remain the cornerstone in the treatment of many malignancies including lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent chemotherapeutics is severely limited by the development of a progressive dose-dependent cardiomyopathy that irreversibly evolves toward congestive heart failure.
Mordente, Alvaro +4 more
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Mitochondria in Postconditioning
Antioxidants & Redox Signaling, 2011Several signal transduction pathways are activated by cardioprotective stimuli, including ischemic or pharmacological postconditioning. These pathways converge on a common target, the mitochondria, and cardioprotection by postconditioning is associated with preserved mitochondrial function after ischemia/reperfusion.
Böngler, Kerstin +2 more
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2010
Publisher Summary This chapter is about mitochondria where the conversion of the chemical energy of carbohydrate into the chemical energy of adenosine triphosphate (ATP) takes place. ATP is involved in many cellular responses, including the synthesis of macromolecules and coenzymes; the activation of fatty acids, amino acids, and sulfate; cell ...
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Publisher Summary This chapter is about mitochondria where the conversion of the chemical energy of carbohydrate into the chemical energy of adenosine triphosphate (ATP) takes place. ATP is involved in many cellular responses, including the synthesis of macromolecules and coenzymes; the activation of fatty acids, amino acids, and sulfate; cell ...
openaire +2 more sources
Virchows Archiv, 2009
The authors review the role played by mutations in mitochondrial DNA and in nuclear genes encoding mitochondrial proteins in cancer development, with an emphasis on the alterations of the oxidative phosphorylation system and glycolysis.
Jorge Lima +6 more
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The authors review the role played by mutations in mitochondrial DNA and in nuclear genes encoding mitochondrial proteins in cancer development, with an emphasis on the alterations of the oxidative phosphorylation system and glycolysis.
Jorge Lima +6 more
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2011
Mitochondria play a central role in the life and death of cells. They are not merely the centre for energy metabolism, but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signalling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species and ...
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Mitochondria play a central role in the life and death of cells. They are not merely the centre for energy metabolism, but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signalling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species and ...
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Modifying with mitochondria [PDF]
Nature Genetics, 2001 An elegant set of mouse crosses has been used to identify a mitochondrial variant that interacts with a nuclear locus on chromosome 10, Ahl, to modify age-related hearing loss. This discovery sets the stage for the identification of factors that modify expression levels and variability of human hearing impairments.
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Annual Review of Genetics, 2004
▪ Abstract Over the past several decades, our knowledge of the origin and evolution of mitochondria has been greatly advanced by determination of complete mitochondrial genome sequences. Among the most informative mitochondrial genomes have been those of protists (primarily unicellular eukaryotes), some of which harbor the most gene-rich and most ...
Michael W. Gray +2 more
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▪ Abstract Over the past several decades, our knowledge of the origin and evolution of mitochondria has been greatly advanced by determination of complete mitochondrial genome sequences. Among the most informative mitochondrial genomes have been those of protists (primarily unicellular eukaryotes), some of which harbor the most gene-rich and most ...
Michael W. Gray +2 more
openaire +3 more sources