Results 41 to 50 of about 916,375 (359)

Mitochondria and Neurodegeneration

Bioscience Reports, 2007
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in ...
PETROZZI, LUCIA, RICCI G, GIGLIOLI NJ, SICILIANO, GABRIELE, MANCUSO, MICHELANGELO   +4 more
openaire   +3 more sources

Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes

Cell Reports, 2023
Summary: Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, which
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian   +10 more
doaj   +1 more source

Mitochondria and Cytoprotection

Biochemistry Research International, 2012
no ...
Brenner, Catherine, Ventura-Clapier, Renée, Jacotot, Etienne   +2 more
openaire   +6 more sources

Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells

Metabolites, 2018
Cellular senescence displays a heterogeneous set of phenotypes linked to tumor suppression; however, after drug treatment, senescence may also be involved in stable or recurrent cancer. Metabolic changes during senescence can provide detailed information
Rong You, Jin Dai, Ping Zhang, Gregory A. Barding, Daniel Raftery   +4 more
doaj   +1 more source

A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]

, 1994
The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
Harkness, Troy A. A., Klei, Ida J. van der, Lill, Roland, Nargang, Frank E., Neupert, Walter   +4 more
core   +8 more sources

Enzymolysis-Driven Development of a Gut-Targeted Aronia melanocarpa Meal Replacement Powder with Glycemic Control and Microbial Homeostasis Benefits

Foods
In this study, the effects of enzymolysis on physicochemical properties, digestive characteristics, and flora regulation of the meal replacement powder (MRP) were investigated on the basis of the previously obtained compound MRP.
Yongxing Li, Zhihui Hu, Haiyu Ji, Shuang Yang, Ruihan Guo, Jinfang Zhang, Hongjun He, Bo Xu, Mei Li   +8 more
doaj   +1 more source

Obesity by High-Fat Diet Increases Pain Sensitivity by Reprogramming Branched-Chain Amino Acid Catabolism in Dorsal Root Ganglia

Frontiers in Nutrition, 2022
Obesity is a significant health concern as a result of poor-quality diet, for example, high-fat diet (HFD). Although multiple biological and molecular changes have been identified to contribute to HFD-induced pain susceptibility, the mechanisms are not ...
Nan Lian, Nan Lian, Nan Lian, Kaiteng Luo, Kaiteng Luo, Huijing Xie, Huijing Xie, Yi Kang, Yi Kang, Kuo Tang, Kuo Tang, Peilin Lu, Peilin Lu, Tao Li, Tao Li   +14 more
doaj   +1 more source

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]

, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui, Chandel, Navdeep S, DeBerardinis, Ralph J, Dickerson, Kathryn E, Gu, Zhimin, Hu, Zeping, Li, Dan, Li, Mushan, Liu, Xin, Ni, Min, Shao, Zhen, Signer, Robert AJ, Weinberg, Samuel E, Xu, Jian, Zhang, Yuannyu, Zhou, Feng   +15 more
core   +1 more source

Aberrant branched-chain amino acid catabolism in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2022
Globally, cardiovascular diseases are the leading cause of death. Research has focused on the metabolism of carbohydrates, fatty acids, and amino acids to improve the prognosis of cardiovascular diseases.
Yixiao Xiong, Yixiao Xiong, Ling Jiang, Ling Jiang, Tao Li, Tao Li   +5 more
doaj   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources