Results 41 to 50 of about 1,007,169 (424)
How mitochondria produce reactive oxygen species
Biochemical Journal, 2008 The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2•−
M. Murphy
semanticscholar +1 more source
Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]
, 2019 The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T. +3 more
core +1 more source
BioMed Research International, 2013 The future of mitochondrial DNA research has the potential to uncover new insights on genetic diseases and open new opportunities to discover ways to control mitochondria and their influence on the human health and cancer. The outcomes of this work will expand the understanding of cellular respiration and disease risk.
Gurmit Singh +3 more
openaire +2 more sources
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Antioxidants, 2022 Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress.
Cindy Barnig +6 more
doaj +1 more source
Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography [PDF]
, 2017 The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria-junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable
Cabrera-Fuentes, Hector +12 more
core +2 more sources
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Journal of Cell Biology, 2008 Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease.
Derek P. Narendra +3 more
semanticscholar +1 more source
Semi-Supervised Segmentation of Mitochondria from Electron Microscopy Images Using Spatial Continuity [PDF]
2022 IEEE 19th International Symposium on Biomedical Imaging
(ISBI). IEEE, 2022: 1-5, 2022 Morphology of mitochondria plays critical roles in mediating their physiological functions. Accurate segmentation of mitochondria from 3D electron microscopy (EM) images is essential to quantitative characterization of their morphology at the nanometer scale.
arxiv +1 more source
Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, N +5 more
core +1 more source
Depletion of mitochondria in mammalian cells through enforced mitophagy [PDF]
, 2016 Mitochondria are not only the 'powerhouse' of the cell; they are also involved in a multitude of processes that include calcium storage, the cell cycle and cell death.
Correia-Melo, Clara +3 more
core +1 more source