Results 41 to 50 of about 845,219 (308)

Mitochondria and Neurodegeneration

Bioscience Reports, 2007
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in ...
PETROZZI, LUCIA, RICCI G, GIGLIOLI NJ, SICILIANO, GABRIELE, MANCUSO, MICHELANGELO   +4 more
openaire   +3 more sources

ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release. [PDF]

, 2017
The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. J. Cell Biol.
Koehler, Carla M, Steffen, Janos
core   +1 more source

Mitochondria and Cytoprotection

Biochemistry Research International, 2012
no ...
Brenner, Catherine, Ventura-Clapier, Renée, Jacotot, Etienne   +2 more
openaire   +6 more sources

Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes

Cell Reports, 2023
Summary: Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, which
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian   +10 more
doaj   +1 more source

Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells

Metabolites, 2018
Cellular senescence displays a heterogeneous set of phenotypes linked to tumor suppression; however, after drug treatment, senescence may also be involved in stable or recurrent cancer. Metabolic changes during senescence can provide detailed information
Rong You, Jin Dai, Ping Zhang, Gregory A. Barding, Daniel Raftery   +4 more
doaj   +1 more source

ER-Mitochondria contact sites : a new regulator of cellular calcium flux comes into play [PDF]

, 2016
Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ...
Anelli, Appenzeller-Herzog, Bittremieux, Booth, Csordás, Cárdenas, Cárdenas, Doghman-Bouguerra, Geert Bultynck, Hayashi, Higo, Krols, Li, Lynes, Lynes, Marchi, Marino, Michiel Krols, Raturi, Rizzuto, Roderick, Sophie Janssens, Szabadkai   +22 more
core   +2 more sources

Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]

, 2016
Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Bannerman, Peter, Burns, Travis, Miers, Laird, Pleasure, David, Xu, Jie   +4 more
core   +7 more sources

Enzymolysis-Driven Development of a Gut-Targeted Aronia melanocarpa Meal Replacement Powder with Glycemic Control and Microbial Homeostasis Benefits

Foods
In this study, the effects of enzymolysis on physicochemical properties, digestive characteristics, and flora regulation of the meal replacement powder (MRP) were investigated on the basis of the previously obtained compound MRP.
Yongxing Li, Zhihui Hu, Haiyu Ji, Shuang Yang, Ruihan Guo, Jinfang Zhang, Hongjun He, Bo Xu, Mei Li   +8 more
doaj   +1 more source

Kinetic Studies on the Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in Intact Cells of Neurospora crassa [PDF]

, 1977
The transport of cytoplasmically synthesized mitochondrial proteins was investigated in whole cells of Neurospora crassa, using dual labelling and immunological techniques.
Hallermayer, Gerhard, Neupert, Walter, Zimmermann, Richard   +2 more
core   +1 more source

Obesity by High-Fat Diet Increases Pain Sensitivity by Reprogramming Branched-Chain Amino Acid Catabolism in Dorsal Root Ganglia

Frontiers in Nutrition, 2022
Obesity is a significant health concern as a result of poor-quality diet, for example, high-fat diet (HFD). Although multiple biological and molecular changes have been identified to contribute to HFD-induced pain susceptibility, the mechanisms are not ...
Nan Lian, Nan Lian, Nan Lian, Kaiteng Luo, Kaiteng Luo, Huijing Xie, Huijing Xie, Yi Kang, Yi Kang, Kuo Tang, Kuo Tang, Peilin Lu, Peilin Lu, Tao Li, Tao Li   +14 more
doaj   +1 more source