Results 51 to 60 of about 1,007,169 (424)
BCL-2 family members and the mitochondria in apoptosis.
Genes & Development, 1999 A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
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Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
Molecular Neurodegeneration, 2020 Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain.
Wenzhang Wang +4 more
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CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
Nature Communications, 2016 β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of ...
Shangcheng Xu +8 more
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Sarcopenia and cardiovascular diseases: A systematic review and meta‐analysis
Journal of Cachexia, Sarcopenia and Muscle, 2023 Sarcopenia is an age‐related disease and is often accompanied by other diseases. Now, many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate of sarcopenia. Therefore, the purpose of this study was to conduct a systematic
Xinrong Zuo +6 more
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How proteins are transported into mitochondria [PDF]
, 1981 Most mitochondrial polypeptides are synthesized outside the organelle as precursors which are usually larger than the ‘mature’ polypeptides found within mitochondria.
Neupert, Walter, Schatz, Gottfried
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Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
JCI Insight, 2020 Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis.
T. Tadokoro +11 more
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Calcium and mitochondria [PDF]
FEBS Letters, 2004 The literature suggests that the physiological functions for which mitochondria sequester Ca2+ are (1) to stimulate and control the rate of oxidative phosphorylation, (2) to induce the mitochondrial permeability transition (MPT) and perhaps apoptotic cell death, and (3) to modify the shape of cytosolic Ca2+ pulses or transients.
Jason D. Salter +4 more
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Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Nature Communications, 2018 Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids,
Dan Shao +11 more
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Preparation and Antioxidant Activities of Phenylethanoids from Dracocephalum heterophyllum
Separations, 2022 The health benefits of Dracocephalum heterophyllum are widely reported in traditional Tibetan medicines, but the reported chemical composition is limited, probably due to difficulties in separating and purifying compounds.
Yue Lv +6 more
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Mitochondria as a Cellular Hub in Infection and Inflammation
International Journal of Molecular Sciences, 2021 Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in
P. Andrieux +3 more
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