Results 51 to 60 of about 698,916 (379)
Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells
Metabolites, 2018 Cellular senescence displays a heterogeneous set of phenotypes linked to tumor suppression; however, after drug treatment, senescence may also be involved in stable or recurrent cancer. Metabolic changes during senescence can provide detailed information
Rong You +4 more
doaj +1 more source
Molecules, 2023 Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration. Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property ...
Haiyu Ji +5 more
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Active thermodynamic force driven mitochondrial alignment [PDF]
arXiv, 2023 Mitochondria are critical organelles in eukaryotes that produce the energy currency ATP. In nerve axons, mitochondria are known to align at almost regular intervals to maintain a constant ATP concentration, but little is known about the mechanism. In this letter, we show theoretically that ATP production and ATP-dependent non-directional movement of ...
arxiv
Piperine Derivatives Enhance Fusion and Axonal Transport of Mitochondria by Activating Mitofusins
Chemistry, 2022 Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted that the
Lihong Zhang +4 more
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Advanced Deep Networks for 3D Mitochondria Instance Segmentation [PDF]
arXiv, 2021 Mitochondria instance segmentation from electron microscopy (EM) images has seen notable progress since the introduction of deep learning methods. In this paper, we propose two advanced deep networks, named Res-UNet-R and Res-UNet-H, for 3D mitochondria instance segmentation from Rat and Human samples.
arxiv
Mitochondrial proteomics: analysis of a whole mitochondrial extract with two-dimensional electrophoresis [PDF]
Methods in molecular biology (Clifton, N.J.) 432 (2008) 83-100, 2008 Mitochondria are complex organelles, and their proteomics analysis requires a combination of techniques. The emphasis in this chapter is made first on mitochondria preparation from cultured mammalian cells, then on the separation of the mitochondrial proteins with two-dimensional electrophoresis (2DE), showing some adjustment over the classical ...
arxiv +1 more source
Cancer & Metabolism, 2014 Editorial Proliferating cells such as tumor cells have increased metabolic demands that include ATP, NADPH, lipids, proteins, and nucleotides to allow for a tumor cell to divide into two daughter cells [1]. Tumor cells reprogram their cell metabolism to sustain the increased metabolic demands of cell proliferation.
openaire +3 more sources
BMC Bioinformatics, 2020 Background Mass spectrometry (MS) has become a promising analytical technique to acquire proteomics information for the characterization of biological samples.
Shisheng Wang +4 more
doaj +1 more source
Mitochondrial Ca2+ uptake in skeletal muscle health and disease [PDF]
, 2016 Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake.
arxiv +1 more source
MiShape: 3D Shape Modelling of Mitochondria in Microscopy [PDF]
arXiv, 2023 Fluorescence microscopy is a quintessential tool for observing cells and understanding the underlying mechanisms of life-sustaining processes of all living organisms. The problem of extracting 3D shape of mitochondria from fluorescence microscopy images remains unsolved due to the complex and varied shapes expressed by mitochondria and the poor ...
arxiv