Results 71 to 80 of about 250,267 (298)
DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology
Scientific Reports, 2017 Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive ...
Sunil Kumar Saini +3 more
doaj +1 more source
Mitochondria-Targeted Drug Delivery
Pharmaceutics, 2022 Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centres [...]
Joanna Kopecka
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The SAR11 group of alpha-proteobacteria is not related to the origin of mitochondria.
PLoS ONE, 2012 Although free living, members of the successful SAR11 group of marine alpha-proteobacteria contain a very small and A+T rich genome, two features that are typical of mitochondria and related obligate intracellular parasites such as the Rickettsiales ...
Naiara Rodríguez-Ezpeleta +1 more
doaj +1 more source
Mitochondrial genetics of alloplasmic male-sterile Brassica napus lines [PDF]
, 2005 Reliable and economical production of hybrid (F1) varieties requires efficient means to control pollination. The predominant system for pollination control of most field crops today is cytoplasmic male sterility (CMS).
Leino, Matti
core
Broad genomic and transcriptional analysis reveals a highly derived genome in dinoflagellate mitochondria [PDF]
BMC Biology, 2007 Abstract Background Dinoflagellates comprise an ecologically significant and diverse eukaryotic phylum that is sister to the phylum containing apicomplexan endoparasites. The mitochondrial genome of apicomplexans is uniquely reduced in gene content and size, encoding only three proteins and two ribosomal RNAs (rRNAs)
Jackson, Christopher J +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
Cells, 2019 Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression.
Damien Jeandard +5 more
doaj +1 more source
ncRNAs: New Players in Mitochondrial Health and Disease?
Frontiers in Genetics, 2020 The regulation of mitochondrial proteome is unique in that its components have origins in both mitochondria and nucleus. With the development of OMICS technologies, emerging evidence indicates an interaction between mitochondria and nucleus based not ...
Mirjana Gusic +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source