Results 101 to 110 of about 712,444 (333)

Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage

Aging, 2020
Cardiac ischemia/reperfusion injury is associated with reduced mitochondrial turnover and regeneration. There is currently no effective approach to stimulate mitochondrial biogenesis in the reperfused myocardium.
Xueyan Qi, Jin Wang
semanticscholar   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Induction of mitochondrial biogenesis enhances neurogenesis and cognitive recovery following ischaemic stroke

Anesthesiology and Perioperative Science
Purpose Stroke can cause severe cognitive impairment in patients. Recently, neurogenesis has been proposed as a potential approach to improve cognitive abilities after stroke.
Fuhai Bai, Zonghong Long, Jing Yang, Ping Liu, Zhuoxi Wu, Hongxu Chen, Youliang Deng, Min Ying, Shanshan Zhang, Jiaxin Li, Yanjuan Chen, Huizhong Wen, Min Zhang, Ying Xiong, Hong Li   +14 more
doaj   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]

, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui, Chandel, Navdeep S, DeBerardinis, Ralph J, Dickerson, Kathryn E, Gu, Zhimin, Hu, Zeping, Li, Dan, Li, Mushan, Liu, Xin, Ni, Min, Shao, Zhen, Signer, Robert AJ, Weinberg, Samuel E, Xu, Jian, Zhang, Yuannyu, Zhou, Feng   +15 more
core   +1 more source

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions.

Physiology, 2019
It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity
D. Bishop, J. Botella, A. Genders, M. Lee, N. Saner, J. Kuang, Xu Yan, C. Granata   +7 more
semanticscholar   +1 more source

Resveratrol can enhance osteogenic differentiation and mitochondrial biogenesis from human periosteum-derived mesenchymal stem cells

Journal of Orthopaedic Surgery and Research, 2020
Background Osteoporosis is a metabolic bone disorder that leads to low bone mass and microstructural deterioration of bone tissue and increases bone fractures.
D. Moon, B. Kim, A. R. Lee, Yeong In Choe, Imran Khan New, Kyoung Mi Moon New, Ryounghoon Jeon, June-Ho Byun, Sun-Chul Hwang, D. Woo   +9 more
semanticscholar   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis

Nature Communications
Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and neurodegenerative disorders.
Kanwar Abhay Singh, John Soukar, Mohammad Zulkifli, Anna Kersey, Giriraj Lokhande, Sagnika Ghosh, Aparna Murali, Natalie M. Garza, Harman Kaur, Justin N. Keeney, Ramu Banavath, Hatice Ceylan Koydemir, Raquel Sitcheran, Irtisha Singh, Vishal M. Gohil, Akhilesh K. Gaharwar   +15 more
doaj   +1 more source

Oxa1 Directly Interacts with Atp9 and Mediates Its Assembly into the Mitochondrial F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase Complex [PDF]

, 2007
The yeast Oxa1 protein is involved in the biogenesis of the mitochondrial oxidative phosphorylation (OXPHOS) machinery. The involvement of Oxa1 in the assembly of the cytochrome oxidase (COX) complex, where it facilitates the cotranslational membrane ...
Dienhart, Mary Kathryn, Jia, Lixia, Stuart, Rosemary A.   +2 more
core   +1 more source