Results 261 to 270 of about 123,664 (300)
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GENETICS OF MITOCHONDRIAL BIOGENESIS
Annual Review of Biochemistry, 1986INTR OD UCTION ..... .. ....... . .... . . . . . . . . .. . . .. . . ....... . . ... . . .. . . ... . ... . . . ........ . ... 249 THE GENETIC FUNCTION OF M ITOCH ONDRIAL DNA ......... ........ . . .. . . . . . . . . . . . . 250 OR GAN IZATION OF M IT OCH ONDRIAL DNA . . . . . . . . . . . . . .. . ......... . . . . .. . . . . . . . . . . . . . .. 256
A, Tzagoloff, A M, Myers
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Mitochondrial biogenesis in neurodegeneration
Journal of Neuroscience Research, 2017Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. Adverse stimulations including neurodegenerative diseases may result in mitochondrial dynamic imbalance, free radical production, calcium accumulation, intrinsic cell death pathway activation and eventually cell death.
P. Andy Li, Xiaolin Hou, Shaocai Hao
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Amino Acids and Mitochondrial Biogenesis
The American Journal of Cardiology, 2008Mitochondria are sources of energy production through their role in producing adenosine triphosphate for cell metabolism. Defective mitochondrial biogenesis and function play relevant roles in the pathophysiology of relevant diseases, including obesity, diabetes mellitus, myopathies, and neurodegenerative diseases.
E. Nisoli, V. Cozzi, M.O. Carruba
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Biogenesis of Mitochondrial Proteins
2012Depending on the organism, mitochondria consist approximately of 500-1,400 different proteins. By far most of these proteins are encoded by nuclear genes and synthesized on cytosolic ribosomes. Targeting signals direct these proteins into mitochondria and there to their respective subcompartment: the outer membrane, the intermembrane space (IMS), the ...
Johannes M, Herrmann +3 more
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Mitochondrial biogenesis in cardiac pathophysiology
Pharmacological Reports, 2009Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac muscle, has to be strictly regulated to adapt to cardiac work.
Stéphanie, Rimbaud +2 more
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Mitochondrial biogenesis in exercise and in ageing☆
Advanced Drug Delivery Reviews, 2009Mitochondrial biogenesis is critical for the normal function of cells. It is well known that mitochondria are produced and eventually after normal functioning they are degraded. Thus, the actual level of mitochondria in cells is dependent both on the synthesis and the degradation.
Jose, Viña +6 more
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Translational regulation of mitochondrial biogenesis
Biochemical Society Transactions, 2016Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell ...
Yi, Zhang, Hong, Xu
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Mitochondrial Biogenesis in Striated Muscle
Canadian Journal of Applied Physiology, 1994Mitochondrial biogenesis (synthesis) has been observed to occur in skeletal muscle in response to chronic use. It also occurs in cardiac muscle during growth and hypertrophy, and it may be impaired during the aging process. This review summarizes the literature on the processes of mitochondrial biogenesis at the biochemical and molecular levels, with ...
D A, Hood +6 more
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2003
Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
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Abstract The chapter focuses on the intensively studied area of protein import into mitochondria and protein maturation within mitochondria. Existing knowledge relies heavily on work done in yeast; recent identification of diseases that result when these processes are disrupted is providing valuable insights into human mitochondrial ...
openaire +1 more source