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Mitochondrial biogenesis: pharmacological approaches. [PDF]
Current pharmaceutical design, 2015 Yes
Valero-Grinan, Teresa M.
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GENETICS OF MITOCHONDRIAL BIOGENESIS
Annual Review of Biochemistry, 1986INTR OD UCTION ..... .. ....... . .... . . . . . . . . .. . . .. . . ....... . . ... . . .. . . ... . ... . . . ........ . ... 249 THE GENETIC FUNCTION OF M ITOCH ONDRIAL DNA ......... ........ . . .. . . . . . . . . . . . . 250 OR GAN IZATION OF M IT OCH ONDRIAL DNA . . . . . . . . . . . . . .. . ......... . . . . .. . . . . . . . . . . . . . .. 256
A, Tzagoloff, A M, Myers
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Mitochondrial biogenesis in neurodegeneration
Journal of Neuroscience Research, 2017Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. Adverse stimulations including neurodegenerative diseases may result in mitochondrial dynamic imbalance, free radical production, calcium accumulation, intrinsic cell death pathway activation and eventually cell death.
P. Andy Li, Xiaolin Hou, Shaocai Hao
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Amino Acids and Mitochondrial Biogenesis
The American Journal of Cardiology, 2008Mitochondria are sources of energy production through their role in producing adenosine triphosphate for cell metabolism. Defective mitochondrial biogenesis and function play relevant roles in the pathophysiology of relevant diseases, including obesity, diabetes mellitus, myopathies, and neurodegenerative diseases.
E. Nisoli, V. Cozzi, M.O. Carruba
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Biogenesis of Mitochondrial Proteins
2012Depending on the organism, mitochondria consist approximately of 500-1,400 different proteins. By far most of these proteins are encoded by nuclear genes and synthesized on cytosolic ribosomes. Targeting signals direct these proteins into mitochondria and there to their respective subcompartment: the outer membrane, the intermembrane space (IMS), the ...
Johannes M, Herrmann +3 more
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Mitochondrial biogenesis in exercise and in ageing☆
Advanced Drug Delivery Reviews, 2009Mitochondrial biogenesis is critical for the normal function of cells. It is well known that mitochondria are produced and eventually after normal functioning they are degraded. Thus, the actual level of mitochondria in cells is dependent both on the synthesis and the degradation.
Jose, Viña +6 more
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Translational regulation of mitochondrial biogenesis
Biochemical Society Transactions, 2016Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell ...
Yi, Zhang, Hong, Xu
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Mitochondrial biogenesis in cardiac pathophysiology
Pharmacological Reports, 2009Cardiac performance depends on a fine balance between the work the heart has to perform to satisfy the needs of the body and the energy that it is able to produce. Thus, energy production by oxidative metabolism, the main energy source of the cardiac muscle, has to be strictly regulated to adapt to cardiac work.
Stéphanie, Rimbaud +2 more
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Isoflavones Promote Mitochondrial Biogenesis
The Journal of Pharmacology and Experimental Therapeutics, 2008Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell (RPTC) injury accelerated the recovery of mitochondrial and cellular functions (Biochem Biophys Res Commun 355:734-739, 2007).
Kyle A, Rasbach, Rick G, Schnellmann
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Biogenesis of mitochondrial membrane proteins
Current Opinion in Cell Biology, 2009Mitochondria are ubiquitous, double-membrane bound organelles, which have developed from endosymbiotic alpha-proteobacteria during evolution. Outer and inner membranes of mitochondria are equipped with characteristic sets of membrane proteins required for energy conversion, metabolite and protein transport, membrane fusion and fission, and signal ...
Becker, Thomas +3 more
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