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MITOCHONDRIAL DYNAMICS IN YEAST

Annual Review of Cell and Developmental Biology, 1998
▪ Abstract  Proteins that control mitochondrial dynamics in yeast are being identified at a rapid pace. These proteins include cytoskeletal elements that regulate organelle distribution and inheritance and several outer membrane proteins that are required to maintain the branched, mitochondrial reticulum.
G J, Hermann, J M, Shaw
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Mitochondrial dynamics

New Phytologist, 2003
SummaryMitochondria cannot be createdde novobut instead must arise from the fission (division) of a parental organelle. In addition to fission, mitochondria also fuse with one another and it is thought that a co‐ordinated balance of these two processes controls mitochondrial shape, size and number.
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Mitochondrial Dynamics in Mammals

2004
This chapter discusses the role of mitochondria dynamics in mammalian mitochondrial morphology, mitochondrial function, disease, embryogenesis, and apoptosis. It defines mitochondria as static, kidney bean-shaped organelles that have the mundane chore of providing energy for the cell.
Chen, Hsiuchen, Chan, David C.
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Mitochondrial dynamics in mitochondrial optic neuropathies

Acta Ophthalmologica, 2013
AbstractOPA1 mutations are the commonest cause of dominantly inherited optic atrophy (DOA) and so‐called DOA plus. The Opa1 protein is essential for normal mitochondrial fusion. In mouse DOA, autophagy (recycling of spent cellular components) is dysregulated in retinal ganglion cells (RGCs), and mitophagy (mitochondrial recycling) has been implicated ...
J POULTON, C LIAO, N ASHLEY
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Mitochondrial Dynamics in Disease

New England Journal of Medicine, 2007
Mitochondria are subcellular organelles that coordinate numerous metabolic reactions, including those of the respiratory complexes that produce the ATP that powers cellular reactions. They have often been depicted as static, with a kidney-bean shape, but there is a growing appreciation of their dynamic nature.
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Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

Trends in Molecular Medicine, 2017
Aging is associated with a decline in mitochondrial function and the accumulation of abnormal mitochondria. However, the precise mechanisms by which aging promotes these mitochondrial alterations and the role of the latter in aging are still not fully understood.
David, Sebastián   +2 more
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Linking mitochondrial dynamics to mitochondrial protein quality control

Current Opinion in Genetics & Development, 2016
Over the last decade, countless discoveries have been made that have expanded our knowledge of mitochondrial biology, and more often than not, these discoveries provided fascinating new insights into the etiology of human disease. For example, advances in mitochondrial genetics exposed the role of mitochondrial mutations in cancer progression, and the ...
Suraiya, Haroon, Marc, Vermulst
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Mitochondrial dynamics in filamentous fungi

Fungal Genetics and Biology, 2002
Mitochondria are essential organelles of eukaryotic cells. They grow continuously throughout the cell cycle and are inherited by daughter cells upon cell division. Inheritance of mitochondria and maintenance of mitochondrial distribution and morphology require active transport of the organelles along the cytoskeleton and depend on membrane fission and ...
Benedikt, Westermann, Holger, Prokisch
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Structural implications of mitochondrial dynamics

Biotechnology Journal, 2008
AbstractMitochondrial components are continuously distributed throughout the whole chondriome of a cell by fusion and fission. Thus, a single mitochondrion represents a transient fraction of the chondriome. Mitochondrial dynamics are responsible for intracellular distribution and reaction of mitochondria to functional requirements.
Jürgen, Bereiter-Hahn   +3 more
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Mitochondrial dynamics coordinate cell differentiation

Biochemical and Biophysical Research Communications, 2018
Cells differentiate into specific and functional lineages to build up tissues. It has been shown in several tissues that mitochondrial morphology, levels of "mitochondria-shaping" proteins, and mitochondrial functions change upon differentiation. In this review, we highlight the significance of mitochondrial dynamics and functions in tissue development,
Masafumi Noguchi, Atsuko Kasahara
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