Results 281 to 290 of about 184,138 (308)
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Mitochondrial dynamics in mitochondrial optic neuropathies
Acta Ophthalmologica, 2013AbstractOPA1 mutations are the commonest cause of dominantly inherited optic atrophy (DOA) and so‐called DOA plus. The Opa1 protein is essential for normal mitochondrial fusion. In mouse DOA, autophagy (recycling of spent cellular components) is dysregulated in retinal ganglion cells (RGCs), and mitophagy (mitochondrial recycling) has been implicated ...
J POULTON, C LIAO, N ASHLEY
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Structural implications of mitochondrial dynamics
Biotechnology Journal, 2008AbstractMitochondrial components are continuously distributed throughout the whole chondriome of a cell by fusion and fission. Thus, a single mitochondrion represents a transient fraction of the chondriome. Mitochondrial dynamics are responsible for intracellular distribution and reaction of mitochondria to functional requirements.
Jürgen, Bereiter-Hahn +3 more
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Mitochondrial Dynamics and Peripheral Neuropathy
The Neuroscientist, 2007Peripheral neuropathy is perhaps the archetypal disease of axonal degeneration, characteristically involving degeneration of the longest axons in the body. Evidence from both inherited and acquired forms of peripheral neuropathy strongly supports that the primary pathology is in the axons themselves and points to disruption of axonal transport as an ...
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Structural dynamics of the mitochondrial compartment
Mutation Research/DNAging, 1992The metabolic activities of mitochondria have been extensively characterized. However, there is much less known about the morphogenic changes of the mitochondrial compartment during growth, development and aging of the cell and the consequences of those structural changes on cellular metabolism.
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Mitochondrial Dynamics in Peripheral Neuropathies
Antioxidants & Redox Signaling, 2014Significance: Mitochondrial dynamics describes the continuous change in the position, size, and shape of mitochondria within cells. The morphological and functional complexity of neurons, the remarkable length of their processes, and the rapid changes in metabolic ...
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Molecular mechanisms of mitochondrial dynamics
Nature Reviews Molecular Cell BiologyMitochondria not only synthesize energy required for cellular functions but are also involved in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation and immunity. Mitochondria are dynamic organelles that undergo cycles of fission and fusion, and these transitions between fragmented and hyperfused networks ensure ...
Luis-Carlos Tábara +2 more
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Mitochondrial Dynamics and Its Involvement in Disease
Annual Review of Pathology: Mechanisms of Disease, 2020David C Chan
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Mitochondrial dynamics proteins as emerging drug targets
Trends in Pharmacological Sciences, 2023Evripidis Gavathiotis
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The cell biology of mitochondrial membrane dynamics
Nature Reviews Molecular Cell Biology, 2020Marta Giacomello +2 more
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The essential functions of mitochondrial dynamics in immune cells
Cellular and Molecular Immunology, 2020Yi-Yuan Li, Jie Jin
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