Results 81 to 90 of about 184,138 (308)
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]
, 2012 Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K. +41 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Targeting mitochondria by mitochondrial fusion, mitochondria-specific peptides and nanotechnology
, 2013 This thesis was focused on mitochondria as an intracellular target for drug delivery by the reason that mitochondria are becoming of increasing interest in pharmaceutical and medical research due to their contribution to several diseases (Chapter 1).
Heller, Anne Sabine
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
MetabolitesBranched-chain amino acids (BCAA) are correlated with severity of insulin resistance, which may partially result from mitochondrial dysfunction. Mitochondrial dysfunction is also common during insulin resistance and is regulated in part by altered ...
Lindsey R. VanDerStad +2 more
doaj +1 more source
Inferring kangaroo phylogeny from incongruent nuclear and mitochondrial genes
, 2013 The marsupial genus Macropus includes three subgenera, the familiar large grazing kangaroos and wallaroos of M. (Macropus) and M. (Osphranter), as well as the smaller mixed grazing/browsing wallabies of M. (Notamacropus).
Pratt, R. +31 more
core +1 more source
The emerging role of Nrf2 in mitochondrial function [PDF]
, 2015 The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Dinkova-Kostova, AT +4 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity. [PDF]
PLoS ONE, 2017 Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network.
Giovanni Dalmasso +3 more
doaj +1 more source
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA [PDF]
, 2014 The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of heteroplasmy (the presence of several alleles in an individual), yet its transmission across generations cannot be readily predicted owing to a lack of data on the size ...
Chiaromonte, Francesca +44 more
core +1 more source