Results 141 to 150 of about 49,263 (303)

p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction

, 2018
Mitochondrial dysfunction is increasingly recognized as an important factor in glomerular diseases. Previous study has shown that mitochondrial fission contributed to mitochondrial dysfunction.
Hui Wang, Min Zhao, Aiqing Zhang, Suyan Duan, Lin Wu, Xi Liu, Jia Qi, Chengning Zhang, Yanggang Yuan, Zhimin Huang, Changying Xing, Bo Zhang, Aihua Zhang   +12 more
core   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Mitochondria- and ER-associated actin are required for mitochondrial fusion

Nature Communications
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove ...
Priya Gatti, Cara Schiavon, Julien Cicero, Uri Manor, Marc Germain   +4 more
doaj   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

A study of mitochondrial biogenesis in the rodent nervous system

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
core  

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, EarlyView.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source

PhD

, 2008
dissertationMitochondria are semiautonomous organelles essential for eukaryotic life. Mitochondria house the machinery required for cellular respiration and energy production, and hundreds of enzymes required for essential biochemical pathways ...
Karren, Mary Anne
core  

Atypical mitochondrial fission upon bacterial infection

, 2013
International audienceWe recently showed that infection by Listeria monocytogenes causes mitochondrial network fragmentation through the secreted pore-forming toxin listeriolysin O (LLO). Here, we examine factors involved in canonical fusion and fission.
Stavru, Fabrizia, Wang, Chunxin, Palmer, Amy E., Youle, Richard J., Cossart, Pascale   +4 more
core   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets

Cell Communication and Signaling
Colorectal cancer (CRC) is a significant public health concern, and its development is associated with mitochondrial dysfunction. Mitochondria can adapt to the high metabolic demands of cancer cells owing to their plasticity and dynamic nature.
Zihong Wu, Chong Xiao, Jing Long, Wenbo Huang, Fengming You, Xueke Li   +5 more
doaj   +1 more source