Results 121 to 130 of about 34,614 (273)

The role of the mitochondrial fission proteins Drp1 and Fis1 in the myeloid lineage [PDF]

, 2023
reservedMitochondria have recently been found to transcend their traditional role as ‘cellular powerhouses’ to emerge as central hubs for cellular metabolism and signaling.
BARTOLAI, FRANCESCO
core  

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Mitochondrial dysfunction in cardiovascular disease: investigating therapeutic approaches to enhance patient outcomes

MGM Journal of Medical Sciences
Mitochondria, the energy-generating organelles, undergo continuous biosynthesis, fission, fusion, and degradation cycles to maintain structural integrity.
Omar Elsaka
doaj   +1 more source

Neurotrophins induce fission of mitochondria along embryonic sensory axons

eLife, 2019
Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial
Lorena Armijo-Weingart, Andrea Ketschek, Rajiv Sainath, Almudena Pacheco, George M Smith, Gianluca Gallo   +5 more
doaj   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress [PDF]

, 2016
Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly understood.
Courchet, Julien, Lewis, Tommy L., Jr., Hellberg, Kristina, Herzig, S., Toyama, Erin Quan, Herzig, Sebastien, Young, Nathan P., Shaw, R., Polleux, Franck, Courchet, J., Loson, O., Toyama, E., Chan, D., Hellberg, K., Lewis, T., Shaw, Reuben J., Young, N., Chen, H., Losón, Oliver C., Chen, Hsiuchen, Chan, David C., Polleux, F.   +21 more
core   +1 more source

Mitochondrial fission and fusion in inflammatory diseases: mechanisms and therapeutic implications

Journal of Translational Medicine
Background Mitochondrial fission and fusion are dynamic and highly regulated processes that are essential for maintaining cellular homeostasis. These processes are regulated by core proteins, including dynamin-related protein 1 (DRP1), fission 1 protein (
Wenjing Xu, Xinru Xu, Yaonan Zhang, Fenfen Li, Daozong Xia   +4 more
doaj   +1 more source

Quantifying the inhibitory effect of Bcl‐xl on the action of Mff using live‐cell fluorescence imaging

FEBS Open Bio, 2019
Mitochondrial fission regulates mitochondrial function and morphology, and has been linked to apoptosis. The mitochondrial fission factor (Mff), a tail‐anchored membrane protein, induces excessive mitochondrial fission, contributing to mitochondrial ...
Yunyun Ma, Mengyan Du, Fangfang Yang, Zihao Mai, Chenshuang Zhang, Wenfeng Qu, Bin Wang, Xiaoping Wang, Tongsheng Chen   +8 more
doaj   +1 more source

INHIBITION OF MITOCHONDRIAL FISSION FAVOURS MUTANT OVER WILD-TYPE MITOCHONDRIAL DNA [PDF]

, 2009
Biased segregation of mitochondrial DNA variants has been widely documented, but little was known about its molecular basis. We set out to test the hypothesis that altering the balance between mitochondrial fusion and fission could influence the ...
MALENA, ADRIANA, LORO E, HOLT JI, DI RE M, VERGANI, LODOVICA   +4 more
core  

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source