Results 1 to 10 of about 1,044,161 (293)

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]

, 2010
The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire, Fan, Ming, Li, Jian Jian, Nantajit, Danupon, Reed, John C, Wen, Yunfei   +5 more
core   +14 more sources

Bioenergetic changes and mitochondrial dysfunction in mania versus euthymia in bipolar disorder type I

European Psychiatry, 2023
Introduction Current evidence has hypothesized the involvement of mitochondrial dysfunction during the acute episodes of BD compared to symptomatic remission.
A. Giménez-Palomo, M. Guitart-Mampel, G. Garrabou, X. Alsina-Restoy, A. Meseguer, L. Colomer, G. Roqué, F. J. García-García, E. Tobías, J. Moisés, M. Valentí, E. Vieta, I. Pacchiarotti   +12 more
doaj   +1 more source

Comment on Yeste et al. Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model. Antioxidants 2021, 10, 1505

Antioxidants, 2022
Intrauterine growth restriction (IUGR) affects 5–10% of newborns and increases the risks of intrauterine demise, neonatal morbidity, and death. In their recent publication, Yeste et al.
Glòria Garrabou, Ana Sandra Hernández, Mariona Guitart-Mampel, Elena Escalada-Casellas, Gemma Malats-Revelles, Sara Castro-Barquero, Ana María Ruiz-León, Kilian Vellvé, Rosa Casas, Francesc Cardellach, Fàtima Crispi, Francesc Josep García-García   +11 more
doaj   +1 more source

The Impact of Mitochondrial Deficiencies in Neuromuscular Diseases

Antioxidants, 2020
Neuromuscular diseases (NMDs) are a heterogeneous group of acquired or inherited rare disorders caused by injury or dysfunction of the anterior horn cells of the spinal cord (lower motor neurons), peripheral nerves, neuromuscular junctions, or skeletal ...
Judith Cantó-Santos, Josep M. Grau-Junyent, Glòria Garrabou   +2 more
doaj   +1 more source

Relevance of sex-differenced analyses in bioenergetics and nutritional studies

Frontiers in Nutrition, 2022
Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males.
Glòria Garrabou, Glòria Garrabou, Francesc Josep García-García, Francesc Josep García-García, Rosa Elvira Presmanes, Maria Feu, Gemma Chiva-Blanch, Gemma Chiva-Blanch   +7 more
doaj   +1 more source

Unravelling inclusion body myositis using a patient‐derived fibroblast model

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Inclusion body myositis (IBM) is an inflammatory myopathy clinically characterized by proximal and distal muscle weakness, with inflammatory infiltrates, rimmed vacuoles and mitochondrial changes in muscle histopathology.
Judith Cantó‐Santos, Laura Valls‐Roca, Ester Tobías, Francesc Josep García‐García, Mariona Guitart‐Mampel, Anna Esteve‐Codina, Beatriz Martín‐Mur, Mercedes Casado, Rafael Artuch, Estel Solsona‐Vilarrasa, José Carlos Fernandez‐Checa, Carmen García‐Ruiz, Carles Rentero, Carlos Enrich, Pedro J. Moreno‐Lozano, José César Milisenda, Francesc Cardellach, Josep M. Grau‐Junyent, Glòria Garrabou   +18 more
doaj   +1 more source

Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects

Antioxidants, 2022
The quantification of mitochondrial respiratory chain (MRC) enzymatic activities is essential for diagnosis of a wide range of mitochondrial diseases, ranging from inherited defects to secondary dysfunctions.
Nuria Bujan, Constanza Morén, Francesc J. García-García, Alberto Blázquez, Clara Carnicer, Ana Belén Cortés, Cristina González, Ester López-Gallardo, Ester Lozano, Sonia Moliner, Laura Gort, Ester Tobías, Aitor Delmiro, Miguel Ángel Martin, Miguel Ángel Fernández-Moreno, Eduardo Ruiz-Pesini, Elena Garcia-Arumí, Juan Carlos Rodríguez-Aguilera, Glòria Garrabou   +18 more
doaj   +1 more source

Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure Prophylaxis in Uninfected Patients

Frontiers in Genetics, 2020
Background: Mitochondrial genome has been used across multiple fields in research, diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents like the human immunodeficiency virus (HIV ...
Maria Bañó, Maria Bañó, Constanza Morén, Constanza Morén, Sergio Barroso, Sergio Barroso, Diana Luz Juárez, Diana Luz Juárez, Mariona Guitart-Mampel, Mariona Guitart-Mampel, Ingrid González-Casacuberta, Ingrid González-Casacuberta, Judith Canto-Santos, Judith Canto-Santos, Ester Lozano, Ester Lozano, Agathe León, Enric Pedrol, Òscar Miró, Ester Tobías, Ester Tobías, Josep Mallolas, Jhon F. Rojas, Francesc Cardellach, Francesc Cardellach, Esteban Martínez, Gloria Garrabou, Gloria Garrabou   +27 more
doaj   +1 more source

Exploring Valine Metabolism in Astrocytic and Liver Cells: Lesson from Clinical Observation in TBI Patients for Nutritional Intervention

Biomedicines, 2020
The utilization of alternative energy substrates to glucose could be beneficial in traumatic brain injury (TBI). Recent clinical data obtained in TBI patients reported valine, β-hydroxyisobutyrate (ibHB) and 2-ketoisovaleric acid (2-KIV) as three of the ...
Sarah Sonnay, Nicolas Christinat, Jonathan Thevenet, Andreas Wiederkehr, Anirikh Chakrabarti, Mojgan Masoodi   +5 more
doaj   +1 more source

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

Pharmaceutical Biology, 2023
Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects.Objective We evaluated the neuroprotective effects of SPJ on aging rats.Materials ...
Cheng Fan, Jin-Xin Wang, Zhang-E. Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang   +8 more
doaj   +1 more source