Results 41 to 50 of about 13,400,035 (354)
PINK1 in mitochondrial function [PDF]
Proceedings of the National Academy of Sciences, 2008 Rare, inherited mutations causing familial forms of Parkinson's disease (PD) have provided much insight into some of the molecular mechanisms that underlie both the genetic and sporadic forms of the disease. The role of mitochondria in sporadic PD has been debated for a little over 20 years, since the identification of complex I deficiency in the ...
Helene, Plun-Favreau, John, Hardy
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Mitochondrial function of human embryo: Decline in their quality with maternal aging
Reproductive Medicine and Biology, 2022 Background Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo.
Shu Hashimoto, Yoshiharu Morimoto
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Cell Death and Differentiation, 2023 The mitochondrial permeability transition (mPT) describes a Ca^2+-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size.
P. Bernardi +8 more
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Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression [PDF]
, 2018 The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated.
Avolio, Carlo +11 more
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Mitochondrial form and function [PDF]
Nature, 2014 Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within ...
Jonathan R, Friedman, Jodi, Nunnari
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Frontiers in Physiology, 2019 Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are used
Sarah Sonnay +6 more
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In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit [PDF]
, 2017 Ndufc2, a subunit of the NADH:ubiquinone oxidoreductase, plays a key role in the assembly and activity of complex I within the mitochondrial OXPHOS chain. Its deficiency has been shown to be involved in diabetes, cancer and stroke.
1000 Genomes Project Consortium +38 more
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Mitochondrial Function in Sepsis [PDF]
Shock, 2016 Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long ...
Nishkantha, Arulkumaran +8 more
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Telomeres and Mitochondrial Function [PDF]
Circulation Research, 2011 ### Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise Sahin et al Nature. 2011;470:359–365. A new study provides insight into aging and age-related diseases by linking telomere dysfunction to a decline in mitochondrial number and function.
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Parkinson's Disease, 2017 Objective. To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson’s disease (PD) subjects. Methods.
C. Morén +14 more
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