Results 21 to 30 of about 13,400,035 (354)

CCN6 regulates mitochondrial function [PDF]

Journal of Cell Science, 2016
ABSTRACT Despite established links of CCN6, or Wnt induced signaling protein-3 (WISP3), with progressive pseudo rheumatoid dysplasia, functional characterization of CCN6 remains incomplete. In light of the documented negative correlation between accumulation of reactive oxygen species (ROS) and CCN6 expression, we investigated whether ...
Milan Patra, Sushil K. Mahata, Deepesh K. Padhan, Malini Sen   +3 more
openaire   +2 more sources

Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure Prophylaxis in Uninfected Patients

Frontiers in Genetics, 2020
Background: Mitochondrial genome has been used across multiple fields in research, diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents like the human immunodeficiency virus (HIV ...
Maria Bañó, Maria Bañó, Constanza Morén, Constanza Morén, Sergio Barroso, Sergio Barroso, Diana Luz Juárez, Diana Luz Juárez, Mariona Guitart-Mampel, Mariona Guitart-Mampel, Ingrid González-Casacuberta, Ingrid González-Casacuberta, Judith Canto-Santos, Judith Canto-Santos, Ester Lozano, Ester Lozano, Agathe León, Enric Pedrol, Òscar Miró, Ester Tobías, Ester Tobías, Josep Mallolas, Jhon F. Rojas, Francesc Cardellach, Francesc Cardellach, Esteban Martínez, Gloria Garrabou, Gloria Garrabou   +27 more
doaj   +1 more source

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Cell Metabolism, 2020
Summary Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span.
L. Bharath, M. Agrawal, Grace McCambridge, Dequina A. Nicholas, H. Hasturk, Jing Liu, K. Jiang, R. Liu, Zhenheng Guo, J. Deeney, C. Apovian, J. Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, R. Pihl, K. Thompson, Anna C. Belkina, Licong Cui, E. Proctor, P. Kern, B. Nikolajczyk   +20 more
semanticscholar   +1 more source

Exploring Valine Metabolism in Astrocytic and Liver Cells: Lesson from Clinical Observation in TBI Patients for Nutritional Intervention

Biomedicines, 2020
The utilization of alternative energy substrates to glucose could be beneficial in traumatic brain injury (TBI). Recent clinical data obtained in TBI patients reported valine, β-hydroxyisobutyrate (ibHB) and 2-ketoisovaleric acid (2-KIV) as three of the ...
Sarah Sonnay, Nicolas Christinat, Jonathan Thevenet, Andreas Wiederkehr, Anirikh Chakrabarti, Mojgan Masoodi   +5 more
doaj   +1 more source

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

Pharmaceutical Biology, 2023
Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects.Objective We evaluated the neuroprotective effects of SPJ on aging rats.Materials ...
Cheng Fan, Jin-Xin Wang, Zhang-E. Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang   +8 more
doaj   +1 more source

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

Cell, 2006
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis.
Marie Lagouge, Carmen A. Argmann, Zachary Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Gény, M. Laakso, P. Puigserver, J. Auwerx   +13 more
semanticscholar   +1 more source

Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]

, 2008
The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie, Liu, Jiankang, Liu, Zhongbo, Long, Jiangang, Luo, Cheng, Ren, Jinmin, Sharman, Edward, Shen, Weili, Tian, Chuan   +8 more
core   +1 more source

Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration

Frontiers in Neuroscience, 2019
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide affecting 2–3% of the population over 65 years. This prevalence is expected to rise as life expectancy increases and diagnostic and therapeutic protocols improve ...
Ingrid González-Casacuberta, Ingrid González-Casacuberta, Diana Luz Juárez-Flores, Diana Luz Juárez-Flores, Constanza Morén, Constanza Morén, Gloria Garrabou, Gloria Garrabou   +7 more
doaj   +1 more source

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia

Frontiers in Cell and Developmental Biology, 2020
The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury.
Mikhail M. Moisenovich, Denis N. Silachev, Denis N. Silachev, Denis N. Silachev, Anastasia M. Moysenovich, Anastasia Yu. Arkhipova, Konstantin V. Shaitan, Vladimir G. Bogush, Vladimir G. Bogush, Vladimir G. Debabov, Vladimir G. Debabov, Alexander V. Latanov, Irina B. Pevzner, Irina B. Pevzner, Ljubava D. Zorova, Ljubava D. Zorova, Valentina A. Babenko, Valentina A. Babenko, Egor Y. Plotnikov, Egor Y. Plotnikov, Egor Y. Plotnikov, Dmitry B. Zorov, Dmitry B. Zorov   +22 more
doaj   +1 more source

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]

, 2017
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T, Berthet, Amandine, Edwards, Robert H, Manfredsson, Fredric P, Nakamura, Ken, Nguyen, Mai K, Orr, Adam L, Pathak, Divya, Sellnow, Rhyomi C, Yu, Katharine   +9 more
core   +1 more source