Results 21 to 30 of about 690,576 (265)
Antioxidants, 2022 The quantification of mitochondrial respiratory chain (MRC) enzymatic activities is essential for diagnosis of a wide range of mitochondrial diseases, ranging from inherited defects to secondary dysfunctions.
Nuria Bujan +18 more
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Mitochondrial form and function [PDF]
Nature, 2014 Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within ...
Jonathan R, Friedman, Jodi, Nunnari
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Frontiers in Genetics, 2020 Background: Mitochondrial genome has been used across multiple fields in research, diagnosis, and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents like the human immunodeficiency virus (HIV ...
Maria Bañó +27 more
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Disorders of mitochondrial function [PDF]
Current Opinion in Pediatrics, 2008 Mitochondrial diseases are a major category of childhood illness that produce a wide variety of symptoms and multisystemic disorders. This review highlights recent clinically important developments in diagnostic evaluation and treatment of mitochondrial diseases.Major advances have been made in understanding the genetic bases of mitochondrial diseases.
Debray, François-Guillaume +2 more
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Biomedicines, 2020 The utilization of alternative energy substrates to glucose could be beneficial in traumatic brain injury (TBI). Recent clinical data obtained in TBI patients reported valine, β-hydroxyisobutyrate (ibHB) and 2-ketoisovaleric acid (2-KIV) as three of the ...
Sarah Sonnay +5 more
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Mitochondrial function in sepsis [PDF]
European Journal of Clinical Investigation, 2013 AbstractBackgroundThe relevance of mitochondrial dysfunction as to pathogenesis of multiple organ dysfunction and failure in sepsis is controversial. This focused review evaluates the evidence for impaired mitochondrial function in sepsis.DesignReview of original studies in experimental sepsis animal models and clinical studies on mitochondrial ...
Jeger Victor +3 more
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Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats
Pharmaceutical Biology, 2023 Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects.Objective We evaluated the neuroprotective effects of SPJ on aging rats.Materials ...
Cheng Fan +8 more
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Frontiers in Neuroscience, 2019 Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide affecting 2–3% of the population over 65 years. This prevalence is expected to rise as life expectancy increases and diagnostic and therapeutic protocols improve ...
Ingrid González-Casacuberta +7 more
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Frontiers in Cell and Developmental Biology, 2020 The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury.
Mikhail M. Moisenovich +22 more
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Antioxidants, 2020 Idiopathic Parkinson’s disease (iPD) and type 2 diabetes mellitus (T2DM) are chronic, multisystemic, and degenerative diseases associated with aging, with eventual epidemiological co-morbidity and overlap in molecular basis. This study aims to explore if
Diana Luz Juárez-Flores +22 more
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