Results 11 to 20 of about 1,044,161 (293)

Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration

Frontiers in Neuroscience, 2019
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide affecting 2–3% of the population over 65 years. This prevalence is expected to rise as life expectancy increases and diagnostic and therapeutic protocols improve ...
Ingrid González-Casacuberta, Ingrid González-Casacuberta, Diana Luz Juárez-Flores, Diana Luz Juárez-Flores, Constanza Morén, Constanza Morén, Gloria Garrabou, Gloria Garrabou   +7 more
doaj   +1 more source

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia

Frontiers in Cell and Developmental Biology, 2020
The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury.
Mikhail M. Moisenovich, Denis N. Silachev, Denis N. Silachev, Denis N. Silachev, Anastasia M. Moysenovich, Anastasia Yu. Arkhipova, Konstantin V. Shaitan, Vladimir G. Bogush, Vladimir G. Bogush, Vladimir G. Debabov, Vladimir G. Debabov, Alexander V. Latanov, Irina B. Pevzner, Irina B. Pevzner, Ljubava D. Zorova, Ljubava D. Zorova, Valentina A. Babenko, Valentina A. Babenko, Egor Y. Plotnikov, Egor Y. Plotnikov, Egor Y. Plotnikov, Dmitry B. Zorov, Dmitry B. Zorov   +22 more
doaj   +1 more source

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]

, 2017
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T, Berthet, Amandine, Edwards, Robert H, Manfredsson, Fredric P, Nakamura, Ken, Nguyen, Mai K, Orr, Adam L, Pathak, Divya, Sellnow, Rhyomi C, Yu, Katharine   +9 more
core   +1 more source

#69 : Decline in Mitochondrial Function of Human Embryo with Maternal Aging

Fertility & Reproduction, 2023
Background and Aims: Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo.
Shu Hashimoto, Yoshiharu Morimoto
doaj   +1 more source

Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity between Age-Related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus

Antioxidants, 2020
Idiopathic Parkinson’s disease (iPD) and type 2 diabetes mellitus (T2DM) are chronic, multisystemic, and degenerative diseases associated with aging, with eventual epidemiological co-morbidity and overlap in molecular basis. This study aims to explore if
Diana Luz Juárez-Flores, Mario Ezquerra, ïngrid Gonzàlez-Casacuberta, Aida Ormazabal, Constanza Morén, Eduardo Tolosa, Raquel Fucho, Mariona Guitart-Mampel, Mercedes Casado, Francesc Valldeoriola, Joan de la Torre-Lara, Esteban Muñoz, Ester Tobías, Yaroslau Compta, Francesc Josep García-García, Carmen García-Ruiz, Jose Carlos Fernandez-Checa, Maria José Martí, Josep Maria Grau, Francesc Cardellach, Rafael Artuch, Rubén Fernández-Santiago, Glòria Garrabou   +22 more
doaj   +1 more source

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. [PDF]

, 2012
BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy.
Bers, Donald M, Chen, Le, Chiamvimonvat, Nipavan, Cortopassi, Gino, Davies, Vanessa, Knowlton, Anne A, Liu, Tingting, Lu, Xiyuan, Tomilov, Alexey A, Tran, Alice, Votruba, Marcela   +10 more
core   +2 more sources

A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]

, 2018
BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin, Burelle, Yan, Coccia, Michael, Cuillerier, Alexanne, Epel, Elissa S, Picard, Martin, Prather, Aric A, Puterman, Eli   +7 more
core   +1 more source

Mechanisms of Cell Damage and Protection in Ischemia/Reperfusion and Experimental Rationale for the Use of Lithium-Based Preparations in Anesthesiology

Общая реаниматология, 2013
Pharmaceuticals based on lithium ions have been already used in clinical practice for over 60 years for the treatment of bipolar disorders and remain a basic pharmacological therapy for patients with this disease.
V. V. Moroz, D. N. Silachev, E. Yu. Plotnikov, L. D. Zorova, I. B. Pevzner, O. A. Grebenchikov, V. V. Likhvantsev   +6 more
doaj   +1 more source

Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]

, 2015
Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A, Edgar, Bruce A, Icreverzi, Amalia, Walker, David W   +3 more
core   +1 more source

Mitochondrial function of human embryo: Decline in their quality with maternal aging

Reproductive Medicine and Biology, 2022
Background Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo.
Shu Hashimoto, Yoshiharu Morimoto
doaj   +1 more source