Results 11 to 20 of about 659,761 (294)

CFTR activity and mitochondrial function

Redox Biology, 2013
Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Angel Gabriel Valdivieso, Tomás A. Santa-Coloma   +1 more
doaj   +4 more sources

Evaluating the mitochondrial function [PDF]

Diabetology & Metabolic Syndrome, 2012
We have read the article by Xia et.al. entitled as "L-carnitine ameliorated fatty liver in high-calorie diet/STZ induced type 2 diabetic mice by improving mitochondrial function" with great interest. In this article, the authors concluded that L-carnitine might be an effective liver cell protector for delaying the progression of type 2 diabetes ...
Akgul Emin, Toygar Mehmet, Poyrazoglu Yavuz   +2 more
doaj   +3 more sources

Mitochondrial Functioning ≠ General Intelligence [PDF]

Journal of Intelligence, 2020
Geary puts forward an appealing argument for the consideration of mitochondrial functioning as a candidate for a formative g Geary (2019); it is also an ambitious argument [...]
Alexander O. Savi, Han L. J. van der Maas, Gunter K. J. Maris, Maarten Marsman   +3 more
openaire   +5 more sources

Mitochondrial function requires NGLY1 [PDF]

Mitochondrion, 2018
Mitochondrial respiratory chain (RC) diseases and congenital disorders of glycosylation (CDG) share extensive clinical overlap but are considered to have distinct cellular pathophysiology. Here, we demonstrate that an essential physiologic connection exists between cellular N-linked deglycosylation capacity and mitochondrial function.
Jianping, Kong, Min, Peng, Julian, Ostrovsky, Young Joon, Kwon, Olga, Oretsky, Elizabeth M, McCormick, Miao, He, Yair, Argon, Marni J, Falk   +8 more
openaire   +2 more sources

CCN6 regulates mitochondrial function [PDF]

Journal of Cell Science, 2016
ABSTRACT Despite established links of CCN6, or Wnt induced signaling protein-3 (WISP3), with progressive pseudo rheumatoid dysplasia, functional characterization of CCN6 remains incomplete. In light of the documented negative correlation between accumulation of reactive oxygen species (ROS) and CCN6 expression, we investigated whether ...
Milan Patra, Sushil K. Mahata, Deepesh K. Padhan, Malini Sen   +3 more
openaire   +2 more sources

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

Pharmaceutical Biology, 2023
Context Panax japonicus is the dried rhizome of Panax japonicus C.A. Mey. (Araliaceae). Saponins from Panax japonicus (SPJ) exhibit anti-oxidative and anti-aging effects.Objective We evaluated the neuroprotective effects of SPJ on aging rats.Materials ...
Cheng Fan, Jin-Xin Wang, Zhang-E. Xiong, Shan-Shan Hu, Ao-Jia Zhou, Ding Yuan, Chang-Cheng Zhang, Zhi-Yong Zhou, Ting Wang   +8 more
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Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration

Frontiers in Neuroscience, 2019
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide affecting 2–3% of the population over 65 years. This prevalence is expected to rise as life expectancy increases and diagnostic and therapeutic protocols improve ...
Ingrid González-Casacuberta, Ingrid González-Casacuberta, Diana Luz Juárez-Flores, Diana Luz Juárez-Flores, Constanza Morén, Constanza Morén, Gloria Garrabou, Gloria Garrabou   +7 more
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Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia

Frontiers in Cell and Developmental Biology, 2020
The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury.
Mikhail M. Moisenovich, Denis N. Silachev, Denis N. Silachev, Denis N. Silachev, Anastasia M. Moysenovich, Anastasia Yu. Arkhipova, Konstantin V. Shaitan, Vladimir G. Bogush, Vladimir G. Bogush, Vladimir G. Debabov, Vladimir G. Debabov, Alexander V. Latanov, Irina B. Pevzner, Irina B. Pevzner, Ljubava D. Zorova, Ljubava D. Zorova, Valentina A. Babenko, Valentina A. Babenko, Egor Y. Plotnikov, Egor Y. Plotnikov, Egor Y. Plotnikov, Dmitry B. Zorov, Dmitry B. Zorov   +22 more
doaj   +1 more source

Mitochondrial function in sepsis [PDF]

European Journal of Clinical Investigation, 2013
AbstractBackgroundThe relevance of mitochondrial dysfunction as to pathogenesis of multiple organ dysfunction and failure in sepsis is controversial. This focused review evaluates the evidence for impaired mitochondrial function in sepsis.DesignReview of original studies in experimental sepsis animal models and clinical studies on mitochondrial ...
Jeger Victor, Djafarzadeh Siamak, Jakob Stephan M, Takala Jukka   +3 more
openaire   +3 more sources

Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity between Age-Related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus

Antioxidants, 2020
Idiopathic Parkinson’s disease (iPD) and type 2 diabetes mellitus (T2DM) are chronic, multisystemic, and degenerative diseases associated with aging, with eventual epidemiological co-morbidity and overlap in molecular basis. This study aims to explore if
Diana Luz Juárez-Flores, Mario Ezquerra, ïngrid Gonzàlez-Casacuberta, Aida Ormazabal, Constanza Morén, Eduardo Tolosa, Raquel Fucho, Mariona Guitart-Mampel, Mercedes Casado, Francesc Valldeoriola, Joan de la Torre-Lara, Esteban Muñoz, Ester Tobías, Yaroslau Compta, Francesc Josep García-García, Carmen García-Ruiz, Jose Carlos Fernandez-Checa, Maria José Martí, Josep Maria Grau, Francesc Cardellach, Rafael Artuch, Rubén Fernández-Santiago, Glòria Garrabou   +22 more
doaj   +1 more source