Results 241 to 250 of about 13,400,035 (354)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient-Derived Brain Organoids. [PDF]

Adv Sci (Weinh)
Zhang Z, Yangzom T, Lu N, Deng S, Xiao X, Yang G, Liang KX.   +6 more
europepmc   +1 more source

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

Proceedings of the National Academy of Sciences of the United States of America, 2017
Sarah Jinn, R. Drolet, Paige E. Cramer, A. Wong, Dawn M. Toolan, C. Gretzula, B. Voleti, G. Vassileva, J. Disa, Marija Tadin-Strapps, David J. Stone   +10 more
semanticscholar   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

XPNPEP2 regulates angiogenesis via modulation of mitochondrial function through SLC25A6. [PDF]

Front Cell Dev Biol
Yang C, Lu Y, Xia Y, Wang B, Xu J, Zhang Y, Yan J, Liu M, Chen T, Zhao X, Cang X, Mao J, Jiang P.   +12 more
europepmc   +1 more source

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD.

Journal of the American Society of Nephrology, 2017
H. Szeto
semanticscholar   +1 more source

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation

Acta Pharmacologica Sinica, 2017
Wei-jin Fang, Chun-jiang Wang, Yang He, Yu-lu Zhou, Xiang-dong Peng, Shi-Kun Liu   +5 more
semanticscholar   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging. [PDF]

Aging Cell
Kojima D, Yaku K, Kosugi S, Mitsuno R, Kaneko K, Kawano Y, Hishikawa A, Mizuno S, Katoh M, Satoh A, Toyokuni S, Azegami T, Kinouchi K, Yamaguchi S, Itoh H, Kanda T, Yamauchi T, Nakagawa T, Hayashi K, Yoshino J.   +19 more
europepmc   +1 more source