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Mitochondrial functions and aging
Gene, 2002In the filamentous ascomycete Podospora anserina mitochondria play a major role in lifespan control. Since the function of these organelles depends on a large number of individual components it is no surprise that a complex network of interacting branches of individual molecular pathways is involved in this process.
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Mitochondrial morphology and function in mitochondrial disease
2023Abstract Mitochondria play a crucial role in maintaining cellular health. It is interesting that the shape of mitochondria can vary depending on the type of cell, mitochondrial function, and other cellular conditions. The morphology of this network is maintained by the balance between mitochondrial fusion and fission, necessary for the ...
Julie Faitg +7 more
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Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
Biogerontology, 2010The impressive performance of the research in biology of mitochondrion has greatly improved our knowledge on the functions of this organelle and highlighted the influence its functioning has on numerous human phenotypes. In particular, many studies have focused on the involvement of mitochondrion function (and dysfunction) in human ageing. To date, the
PASSARINO, Giuseppe +2 more
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Modeling mitochondrial function
American Journal of Physiology-Cell Physiology, 2006The mitochondrion represents a unique opportunity to apply mathematical modeling to a complex biological system. Understanding mitochondrial function and control is important since this organelle is critical in energy metabolism as well as playing key roles in biochemical synthesis, redox control/signaling, and apoptosis.
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Crosstalk between mitochondrial (dys)function and mitochondrial abundance
Journal of Cellular Physiology, 2012AbstractA controlled regulation of mitochondrial mass through either the production (biogenesis) or the degradation (mitochondrial quality control) of the organelle represents a crucial step for proper mitochondrial and cell function. Key steps of mitochondrial biogenesis and quality control are overviewed, with an emphasis on the role of mitochondrial
Michel, Sébastien +5 more
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Mitochondrial function in neurodegeneration and ageing
Mutation Research/DNAging, 1992The mitochondrial respiratory chain and oxidative phosphorylation system are responsible for the production of ATP by aerobic metabolism. Defects of the respiratory chain are increasingly recognised as important causes of human disease, and neurodegenerative disorders in particular.
A H, Schapira, J M, Cooper
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Mitochondrial function in liver disease
Frontiers in Bioscience, 2007Oxidative stress is involved in the pathogenesis and progression of different liver diseases, such as alcoholic liver disease and biliary cirrhosis. The increased mitochondrial production of O2(-) at complexes I and III, and consequently of H2O2 and other reactive oxygen species (ROS), triggered by NADH overproduction seems the major cause of ...
SASTRE J. +8 more
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Determinants and Functions of Mitochondrial Behavior
Annual Review of Cell and Developmental Biology, 2014Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the behavior of mitochondria inside eukaryotic cells has changed dramatically, and the corresponding machineries that control it are in most cases new inventions.
Katherine, Labbé +2 more
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Structure and Function of the Mitochondrial Ribosome
Annual Review of Biochemistry, 2016Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by ...
Basil J, Greber, Nenad, Ban
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Mitochondrial Function in Allergic Disease
Current Allergy and Asthma Reports, 2017The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function ...
Divyaanka, Iyer +2 more
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