Results 231 to 240 of about 690,576 (265)

Mitochondrial functions in stem cells

Current Opinion in Genetics & Development, 2016
Mitochondria fulfill multiple cellular functions beyond ATP production, including several functions that are specialized for distinct tissue types (thermogenesis, steroidogenesis). Recent evidence indicates that mitochondrial activities are regulated within cell lineages, and through incompletely understood mechanisms, are important for specification ...
Daciana H, Margineantu, David M, Hockenbery   +1 more
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Mitochondrial function, ornamentation, and immunocompetence

Biological Reviews, 2016
ABSTRACTUnderstanding the mechanisms that link ornamental displays and individual condition is key to understanding the evolution and function of ornaments. Immune function is an aspect of individual quality that is often associated with the expression of ornamentation, but a general explanation for why the expression of some ornaments seems to be ...
Rebecca E. Koch, Chloe C. Josefson, Geoffrey E. Hill   +2 more
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The functional compartmentation of mitochondrial hexokinase

Archives of Biochemistry and Biophysics, 1974
Abstract These studies examined the functional relationship between rat hepatic mitochondria and associated hexokinase (ATP: d -hexose-6-phosphotransferase, 2.7.1.1) to determine whether the binding of hexokinase to mitochondria might provide a privileged interaction with sites of ATP production.
R E, Gots, S P, Bessman
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Triptolide Alters Mitochondrial Functions

2007
Triptolide (TPL), a small molecule purified from the herb Tripterygium wilfordii, has potential clinical application for suppression of chronic autoimmune disorders and inhibition of tumor growth. However, its mechanism of action is largely unknown.
Ying, Su, Shanmin, Yang, Zhenyu, Xiao, Wei, Wang, Paul, Okunieff, Lurong, Zhang   +5 more
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Mitochondrial function in cardiac hypertrophy

International Journal of Cardiology, 2013
Cardiac hypertrophic program is a chronic, complex process, and occurs in response to long-term increases of hemodynamic load related to a variety of pathophysiological conditions. Mitochondria, known as "the cellular power plants", occupy about one-third of cardiomyocyte volume and supply roughly 90% of the adenosine triphosphate (ATP).
Lu-Yu, Zhou, Jin-Ping, Liu, Kun, Wang, Jie, Gao, Su-Ling, Ding, Jian-Qin, Jiao, Pei-Feng, Li   +6 more
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Mitochondrial function in Babesia bovis

International Journal for Parasitology, 1992
A variety of anti-mitochondrial drugs that had previously been found to inhibit the growth of the malarial parasite Plasmodium falciparum were tested on Babesia bovis in vitro. Several of these drugs were found to be non-toxic towards B. bovis. However, those drugs that were found to inhibit babesial growth included compounds (shown in parentheses ...
M M, Gozar, W J, O'Sullivan, A S, Bagnara   +2 more
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Methods to detect mitochondrial function

Experimental Gerontology, 2004
The bioenergetic function of mitochondria can be investigated in intact cells by a variety of methods. A simple biochemical method to compare mitochondrial oxidative phosphorylation with glycolytic ATP synthesis takes advantage of the Pasteur effect, since the amount of lactate produced under basal conditions is an indication of glycolytic ATP, while ...
MERLO PICH, MILENA, DELEONARDI G., BIONDI, ANNALISA, LENAZ, GIORGIO   +3 more
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Influence of cytarabine on mitochondrial function and mitochondrial biogenesis.

Seminars in oncology, 1987
Although replication of nuclear DNA is inhibited by cytarabine (ara-C), protein synthesis in the nucleocytoplasm appears to continue unabated for the duration of at least the time of the normal cell cycle. ara-C treatment of human leukemic cells resulted in increased mitochondrial membrane potential and adenosine-5'-triphosphate (ATP) production and ...
MUUS, P, HAANEN, C, PENNINGS, A, RUITENBEEK, W, VANDENBOGERT, C   +4 more
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Mitochondrial Function and Dysfunction: An Update

The Journal of Pharmacology and Experimental Therapeutics, 2012
With the current explosion of knowledge on the role of mitochondrial dysfunction in the genesis of various human disease states, there is an increased interest in targeting mitochondrial processes, pathways, and proteins for drug discovery efforts in cancer and cardiovascular, metabolic, and central nervous system diseases, the latter including autism ...
Robert E, Davis, Michael, Williams
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Mitochondrial DNA structure and function

2002
Publisher Summary This chapter discusses mitochondrial DNA (mtDNA) structures and its functions. The human mtDNA is representative of mammalian mitochondrial genomes. Comparison of the nucleotide sequences of mammal mtDNA revealed some degree of conservation in the promoter regions as well as in three other regions (termed “Conserved Sequence Blocks,”
Carlos T, Moraes, Sarika, Srivastava, Ilias, Kirkinezos, Jose, Oca-Cossio, Corina, van Waveren, Markus, Woischnick, Francisca, Diaz   +6 more
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