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Disorders of mitochondrial function [PDF]
Current Opinion in Pediatrics, 2008 Mitochondrial diseases are a major category of childhood illness that produce a wide variety of symptoms and multisystemic disorders. This review highlights recent clinically important developments in diagnostic evaluation and treatment of mitochondrial diseases.Major advances have been made in understanding the genetic bases of mitochondrial diseases.
Debray, François-Guillaume +2 more
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Общая реаниматология, 2013 Pharmaceuticals based on lithium ions have been already used in clinical practice for over 60 years for the treatment of bipolar disorders and remain a basic pharmacological therapy for patients with this disease.
V. V. Moroz +6 more
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PINK1 in mitochondrial function [PDF]
Proceedings of the National Academy of Sciences, 2008 Rare, inherited mutations causing familial forms of Parkinson's disease (PD) have provided much insight into some of the molecular mechanisms that underlie both the genetic and sporadic forms of the disease. The role of mitochondria in sporadic PD has been debated for a little over 20 years, since the identification of complex I deficiency in the ...
Helene, Plun-Favreau, John, Hardy
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Frontiers in Physiology, 2019 Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are used
Sarah Sonnay +6 more
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Mitochondrial function of human embryo: Decline in their quality with maternal aging
Reproductive Medicine and Biology, 2022 Background Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo.
Shu Hashimoto, Yoshiharu Morimoto
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Mitochondrial form and function [PDF]
Nature, 2014 Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within ...
Jonathan R, Friedman, Jodi, Nunnari
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Mitochondrial Function in Sepsis [PDF]
Shock, 2016 Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long ...
Nishkantha, Arulkumaran +8 more
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Telomeres and Mitochondrial Function [PDF]
Circulation Research, 2011 ### Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise Sahin et al Nature. 2011;470:359–365. A new study provides insight into aging and age-related diseases by linking telomere dysfunction to a decline in mitochondrial number and function.
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Parkinson's Disease, 2017 Objective. To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson’s disease (PD) subjects. Methods.
C. Morén +14 more
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Life, 2021 Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction.
Cristian Adrián Márquez-Ramírez +7 more
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