Results 21 to 30 of about 1,044,161 (293)

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression [PDF]

, 2018
The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated.
Avolio, Carlo, Bellanti, Francesco, Blonda, Maria, di Bello, Giorgia, Facciorusso, Antonio, Iannelli, Giuseppina, Iuliano, Luigi, Poli, Giuseppe, Serviddio, Gaetano, Tamborra, Rosanna, Vendemiale, Gianluigi, Villani, Rosanna   +11 more
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Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes

Frontiers in Physiology, 2019
Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are used
Sarah Sonnay, Anirikh Chakrabarti, Jonathan Thevenet, Andreas Wiederkehr, Nicolas Christinat, Mojgan Masoodi, Mojgan Masoodi   +6 more
doaj   +1 more source

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. [PDF]

, 2015
Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the ...
Berthet, A, Diaz-Ramirez, LG, Gill, TM, Haddad, D, Kim, H, Lam, M, Mucke, L, Nakamura, K, Pathak, D, Ponnusamy, R, Sesaki, H, Shields, LY, Zhu, L   +12 more
core   +3 more sources

Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress

Life, 2021
Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction.
Cristian Adrián Márquez-Ramírez, Berenice Eridani Olmos-Orizaba, Claudia Isabel García-Berumen, Elizabeth Calderón-Cortés, Rocío Montoya-Pérez, Alfredo Saavedra-Molina, Alain Raimundo Rodríguez-Orozco, Christian Cortés-Rojo   +7 more
doaj   +1 more source

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]

, 2018
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti, Abou-Sleiman, Adam-Vizi, Alexis A. Robinson, Ariga, Banerjee, Ben-Nissan, Blackinton, Boland, Bonifati, Bonifati, Brenner-Lavie, Campanella, Canet-Avilés, Cannon, Carlo Rodolfo, Caterina Ferraina, Chen, Daniela Strobbe, Dauer, Dias, Duchen, D’Autréaux, East, Gatliff, Georgakopoulos, Giaime, Giordano, Görner, Harvey, Hulleman, Junn, Kahle, Kim, Kirsten Harvey, Lakshminarasimhan, Lara Rossi, Lücking, Maita, Martinat, Martinez-Vicente, Matic, Michelangelo Campanella, Moscovitz, Muller, Murphy, Narendra, Niki, Olzmann, Ono, Onyango, Paisán-Ruíz, Pankratz, Parker, Parsanejad, Polymeropoulos, Robert J. Harvey, Schon, Shendelman, Shinbo, Taira, Takahashi, Takahashi-Niki, Valente, Valerio de Biase, Waak, Wang   +66 more
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Colonic Oxidative and Mitochondrial Function in Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder

Parkinson's Disease, 2017
Objective. To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson’s disease (PD) subjects. Methods.
C. Morén, Í. González-Casacuberta, J. Navarro-Otano, D. Juárez-Flores, D. Vilas, G. Garrabou, J. C. Milisenda, C. Pont-Sunyer, M. Catalán-García, M. Guitart-Mampel, E. Tobías, F. Cardellach, F. Valldeoriola, A. Iranzo, E. Tolosa   +14 more
doaj   +1 more source

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Nature Communications, 2022
Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes ...
Zhisheng Xu, Tingting Fu, Qiqi Guo, Danxia Zhou, Wanping Sun, Zheng Zhou, Xinyi Chen, Jingzi Zhang, Lin Liu, Liwei Xiao, Yujing Yin, Yuhuan Jia, Erkai Pang, Yuncong Chen, Xin Pan, Lei Fang, Min-sheng Zhu, Wenyong Fei, Bin Lu, Zhenji Gan   +19 more
doaj   +1 more source

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. [PDF]

, 2016
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis.
Jiao, Kun, Lau, Wayne Bond, Liu, Huirong, Liu, Xin, Ma, Lu, Ma, Xinliang, Shang, Jianyu, Wang, Ke, Wang, Wen, Wang, Xiaoliang, Yuan, Yuexing, Zuo, Lin   +11 more
core   +2 more sources

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease

Journal of Translational Medicine, 2018
Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed
Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou   +15 more
doaj   +1 more source

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]

, 2020
To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju, Duan, Yaoyun, Fan, Feifei, Fang, Xi, Huang, Lei, Jia, Nan, Li, Yali, Liu, Jie, Ouyang, Kunfu, Tang, Huayuan, Trexler, Christa, Wang, Gang, Wang, Hong, Yang, Feili   +13 more
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