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Disorders of mitochondrial function [PDF]

Current Opinion in Pediatrics, 2008
Mitochondrial diseases are a major category of childhood illness that produce a wide variety of symptoms and multisystemic disorders. This review highlights recent clinically important developments in diagnostic evaluation and treatment of mitochondrial diseases.Major advances have been made in understanding the genetic bases of mitochondrial diseases.
Debray, François-Guillaume, Lambert, M., Mitchell, G. A.   +2 more
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Mechanisms of Cell Damage and Protection in Ischemia/Reperfusion and Experimental Rationale for the Use of Lithium-Based Preparations in Anesthesiology

Общая реаниматология, 2013
Pharmaceuticals based on lithium ions have been already used in clinical practice for over 60 years for the treatment of bipolar disorders and remain a basic pharmacological therapy for patients with this disease.
V. V. Moroz, D. N. Silachev, E. Yu. Plotnikov, L. D. Zorova, I. B. Pevzner, O. A. Grebenchikov, V. V. Likhvantsev   +6 more
doaj   +1 more source

PINK1 in mitochondrial function [PDF]

Proceedings of the National Academy of Sciences, 2008
Rare, inherited mutations causing familial forms of Parkinson's disease (PD) have provided much insight into some of the molecular mechanisms that underlie both the genetic and sporadic forms of the disease. The role of mitochondria in sporadic PD has been debated for a little over 20 years, since the identification of complex I deficiency in the ...
Helene, Plun-Favreau, John, Hardy
openaire   +2 more sources

Mitochondrial function of human embryo: Decline in their quality with maternal aging

Reproductive Medicine and Biology, 2022
Background Female fertility declines with age, due to increased chromosomal aneuploidy and possible reduced mitochondrial function in the embryo.
Shu Hashimoto, Yoshiharu Morimoto
doaj   +1 more source

Mitochondrial form and function [PDF]

Nature, 2014
Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within ...
Jonathan R, Friedman, Jodi, Nunnari
openaire   +2 more sources

Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes

Frontiers in Physiology, 2019
Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are used
Sarah Sonnay, Anirikh Chakrabarti, Jonathan Thevenet, Andreas Wiederkehr, Nicolas Christinat, Mojgan Masoodi, Mojgan Masoodi   +6 more
doaj   +1 more source

Mitochondrial Function in Sepsis [PDF]

Shock, 2016
Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long ...
Nishkantha, Arulkumaran, Clifford S, Deutschman, Michael R, Pinsky, Brian, Zuckerbraun, Paul T, Schumacker, Hernando, Gomez, Alonso, Gomez, Patrick, Murray, John A, Kellum   +8 more
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Telomeres and Mitochondrial Function [PDF]

Circulation Research, 2011
### Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise Sahin et al Nature. 2011;470:359–365. A new study provides insight into aging and age-related diseases by linking telomere dysfunction to a decline in mitochondrial number and function.
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Colonic Oxidative and Mitochondrial Function in Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder

Parkinson's Disease, 2017
Objective. To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson’s disease (PD) subjects. Methods.
C. Morén, Í. González-Casacuberta, J. Navarro-Otano, D. Juárez-Flores, D. Vilas, G. Garrabou, J. C. Milisenda, C. Pont-Sunyer, M. Catalán-García, M. Guitart-Mampel, E. Tobías, F. Cardellach, F. Valldeoriola, A. Iranzo, E. Tolosa   +14 more
doaj   +1 more source

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease

Journal of Translational Medicine, 2018
Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed
Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou   +15 more
doaj   +1 more source