Results 301 to 310 of about 13,400,035 (354)

Mitochondrial function and gastrointestinal diseases

Nature Reviews Gastroenterology & Hepatology
Mitochondria are dynamic organelles that function in cellular energy metabolism, intracellular and extracellular signalling, cellular fate and stress responses. Mitochondria of the intestinal epithelium, the cellular interface between self and enteric microbiota, have emerged as crucial in intestinal health.
Parsa S. Haque, Neeraj Kapur, Terrence A. Barrett, Arianne L. Theiss   +3 more
semanticscholar   +3 more sources

Mitochondrial phospholipids: role in mitochondrial function

Journal of Bioenergetics and Biomembranes, 2015
Mitochondria are essential components of eukaryotic cells and are involved in a diverse set of cellular processes that include ATP production, cellular signalling, apoptosis and cell growth. These organelles are thought to have originated from a symbiotic relationship between prokaryotic cells in an effort to provide a bioenergetic jump and thus, the ...
Edgard M, Mejia, Grant M, Hatch
openaire   +2 more sources

PGC-1α-mediated regulation of mitochondrial function and physiological implications.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2020
The majority of human energy metabolism occurs in skeletal muscle mitochondria emphasizing the importance of understanding the regulation of myocellular mitochondrial function.
J. Halling, H. Pilegaard
semanticscholar   +1 more source

Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function.

Clinica chimica acta; international journal of clinical chemistry, 2020
Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which seriously reduces the quality of life of patients and places a heavy economic burden on their families.
Guangzhi Zhang, Yajun Deng, Qi-qi Xie, En-hui Ren, Zhanjun Ma, Xuegang He, Yicheng Gao, X. Kang   +7 more
semanticscholar   +1 more source

Melatonin and mitochondrial function

Life Sciences, 2004
Melatonin is a natural occurring compound with well-known antioxidant properties. In the last decade a new effect of melatonin on mitochondrial homeostasis has been discovered and, although the exact molecular mechanism for this effect remains unknown, it may explain, at least in part, the protective properties found for the indoleamine in degenerative
Josefa, Leon, Dario, Acuña-Castroviejo, Rosa M, Sainz, Juan C, Mayo, Dun-Xian, Tan, Russel J, Reiter   +5 more
openaire   +2 more sources

Mitochondrial function in shock

The American Journal of Emergency Medicine, 1984
Studies utilizing animal models of circulatory shock have revealed mitochondrial structural and functional damage in the liver, kidney, and brain. Adenosine triphosphate (ATP) synthesis and calcium transport rates of these mitochondria decline significantly during circulatory shock.
L, Mela-Riker, H, Tavakoli
openaire   +2 more sources

Modeling mitochondrial function

American Journal of Physiology-Cell Physiology, 2006
The mitochondrion represents a unique opportunity to apply mathematical modeling to a complex biological system. Understanding mitochondrial function and control is important since this organelle is critical in energy metabolism as well as playing key roles in biochemical synthesis, redox control/signaling, and apoptosis.
openaire   +2 more sources

Mitochondrial function in melanoma

Archives of Biochemistry and Biophysics, 2014
Melanoma is the most lethal form of skin cancer and its incidence is rapidly rising. Breakthroughs in the understanding of the basic biology of melanoma in the past decade have yielded several new treatments, and advances continue to be made on a variety of fronts.
Nicholas, Theodosakis, Goran, Micevic, Daniel P, Kelly, Marcus, Bosenberg   +3 more
openaire   +2 more sources

Mitochondrial functions of polymelanosomes

Comparative Biochemistry and Physiology, 1967
Abstract 1. 1. Large cytoplasmic organelles containing melanin granules (polymelanosomes) were centrifugally isolated from the melanocytes of the Amphiuma tridactylum liver. 2. 2. These polymelanosomes have significant amounts of the following enzyme activities: succinic oxidase, cytochrome oxidase and monoamine oxidase. 3. 3.
M H, Van Woert, A, Nicholson, G C, Cotzias   +2 more
openaire   +2 more sources

Triptolide Alters Mitochondrial Functions

2007
Triptolide (TPL), a small molecule purified from the herb Tripterygium wilfordii, has potential clinical application for suppression of chronic autoimmune disorders and inhibition of tumor growth. However, its mechanism of action is largely unknown.
Ying, Su, Shanmin, Yang, Zhenyu, Xiao, Wei, Wang, Paul, Okunieff, Lurong, Zhang   +5 more
openaire   +2 more sources