Results 311 to 320 of about 13,400,035 (354)

The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes.

Archives of Biochemistry and Biophysics, 2019
Excessive iron accumulation in the heart can lead to iron overload cardiomyopathy (IOC), the leading cause of death in hemochromatosis patients. Current understanding regarding the mechanism by which iron overload causes a deterioration in cardiac ...
Natticha Sumneang, Natthaphat Siri-Angkul, S. Kumfu, S. Chattipakorn, N. Chattipakorn   +4 more
semanticscholar   +1 more source

Carnitine, mitochondrial function and therapy☆

Advanced Drug Delivery Reviews, 2009
Carnitine is important for cell function and survival primarily because of its involvement in the multiple equilibria between acylcarnitine and acyl-CoA esters established through the enzymatic activities of the family of carnitine acyltransferases. These have different acyl chain-length specificities and intracellular compartment distributions, and ...
Zammit VA, Ramsay RR, BONOMINI, Mario, Arduini Arduino   +3 more
openaire   +2 more sources

Mitochondrial functions and aging

Gene, 2002
In the filamentous ascomycete Podospora anserina mitochondria play a major role in lifespan control. Since the function of these organelles depends on a large number of individual components it is no surprise that a complex network of interacting branches of individual molecular pathways is involved in this process.
openaire   +2 more sources

Crosstalk between mitochondrial (dys)function and mitochondrial abundance

Journal of Cellular Physiology, 2012
AbstractA controlled regulation of mitochondrial mass through either the production (biogenesis) or the degradation (mitochondrial quality control) of the organelle represents a crucial step for proper mitochondrial and cell function. Key steps of mitochondrial biogenesis and quality control are overviewed, with an emphasis on the role of mitochondrial
Michel, Sébastien, Wanet, Anaïs, De Pauw, Aurélia, Rommelaere, Guillaume, Arnould, Thierry, Renard, Patricia   +5 more
openaire   +3 more sources

Mitochondrial function, ornamentation, and immunocompetence

Biological Reviews, 2017
ABSTRACTUnderstanding the mechanisms that link ornamental displays and individual condition is key to understanding the evolution and function of ornaments. Immune function is an aspect of individual quality that is often associated with the expression of ornamentation, but a general explanation for why the expression of some ornaments seems to be ...
Rebecca E. Koch, Chloe C. Josefson, G. Hill   +2 more
semanticscholar   +3 more sources

Effects of cryopreservation on mitochondrial function and sperm quality in fish

Aquaculture, 2019
The development of cryopreservation techniques has led to important changes in animal reproductive biotechnology. However, these techniques are associated with cellular and molecular damage, affecting the mitochondrial function and quality of spermatozoa;
E. Figueroa, Manuel Lee-Estevez, I. Valdebenito, I. Watanabe, R. Oliveira, J. Romero, R. Castillo, J. Farías   +7 more
semanticscholar   +1 more source

Mitochondrial functional complementation in mitochondrial DNA-based diseases

The International Journal of Biochemistry & Cell Biology, 2009
Mitochondria exist in networks that are continuously remodeled through fusion and fission. Why do individual mitochondria in living cells fuse and divide continuously? Protein machinery and molecular mechanism for the dynamic nature of mitochondria have been almost clarified.
Kazuto, Nakada, Akitsugu, Sato, Jun-ichi, Hayashi   +2 more
openaire   +2 more sources

Mitochondrial function, mitochondrial DNA and ageing: a reappraisal

Biogerontology, 2010
The impressive performance of the research in biology of mitochondrion has greatly improved our knowledge on the functions of this organelle and highlighted the influence its functioning has on numerous human phenotypes. In particular, many studies have focused on the involvement of mitochondrion function (and dysfunction) in human ageing. To date, the
PASSARINO, Giuseppe, ROSE, Giuseppina, BELLIZZI, Dina   +2 more
openaire   +3 more sources

Mitochondrial functions in stem cells

Current Opinion in Genetics & Development, 2016
Mitochondria fulfill multiple cellular functions beyond ATP production, including several functions that are specialized for distinct tissue types (thermogenesis, steroidogenesis). Recent evidence indicates that mitochondrial activities are regulated within cell lineages, and through incompletely understood mechanisms, are important for specification ...
Daciana H, Margineantu, David M, Hockenbery   +1 more
openaire   +2 more sources

Mitochondrial function in Babesia bovis

International Journal for Parasitology, 1992
A variety of anti-mitochondrial drugs that had previously been found to inhibit the growth of the malarial parasite Plasmodium falciparum were tested on Babesia bovis in vitro. Several of these drugs were found to be non-toxic towards B. bovis. However, those drugs that were found to inhibit babesial growth included compounds (shown in parentheses ...
M M, Gozar, W J, O'Sullivan, A S, Bagnara   +2 more
openaire   +2 more sources