Results 31 to 40 of about 659,761 (294)

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease

Journal of Translational Medicine, 2018
Background Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed
Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou   +15 more
doaj   +1 more source

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Nature Communications, 2022
Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes ...
Zhisheng Xu, Tingting Fu, Qiqi Guo, Danxia Zhou, Wanping Sun, Zheng Zhou, Xinyi Chen, Jingzi Zhang, Lin Liu, Liwei Xiao, Yujing Yin, Yuhuan Jia, Erkai Pang, Yuncong Chen, Xin Pan, Lei Fang, Min-sheng Zhu, Wenyong Fei, Bin Lu, Zhenji Gan   +19 more
doaj   +1 more source

Viral Infection Modulates Mitochondrial Function [PDF]

International Journal of Molecular Sciences, 2021
Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of diseases.
Li, Xiaowen, Wu, Keke, Zeng, Sen, Zhao, Feifan, Fan, Jindai, Li, Zhaoyao, Yi, Lin, Ding, Hongxing, Zhao, Mingqiu, Fan, Shuangqi, Chen, Jinding   +10 more
openaire   +2 more sources

Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

Physiological Reports, 2020
We investigated the acute and chronic effects of resistance training (RT) on skeletal muscle markers of mitochondrial content and remodeling in older, untrained adults.
Paulo H.C. Mesquita, Donald A. Lamb, Hailey A. Parry, Johnathon H. Moore, Morgan A. Smith, Christopher G. Vann, Shelby C. Osburn, Carlton D. Fox, Bradley A. Ruple, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts   +13 more
doaj   +1 more source

Targeting Mitochondrial Function with Chemoptogenetics

Biomedicines, 2022
Mitochondria are ATP-generating organelles in eukaryotic cells that produce reactive oxygen species (ROS) during oxidative phosphorylation (OXPHOS). Mitochondrial DNA (mtDNA) is packaged within nucleoids and, due to its close proximity to ROS production,
Amy Romesberg, Bennett Van Houten
doaj   +1 more source

Mitochondrial structure and function are disrupted by standard isolation methods. [PDF]

PLoS ONE, 2011
Mitochondria regulate critical components of cellular function via ATP production, reactive oxygen species production, Ca(2+) handling and apoptotic signaling.
Martin Picard, Tanja Taivassalo, Darmyn Ritchie, Kathryn J Wright, Melissa M Thomas, Caroline Romestaing, Russell T Hepple   +6 more
doaj   +1 more source

Natural Compounds Modulating Mitochondrial Functions [PDF]

Evidence-Based Complementary and Alternative Medicine, 2015
Mitochondria are organelles responsible for several crucial cell functions, including respiration, oxidative phosphorylation, and regulation of apoptosis; they are also the main intracellular source of reactive oxygen species (ROS). In the last years, a particular interest has been devoted to studying the effects on mitochondria of natural compounds of
GIBELLINI, Lara, BIANCHINI, ELENA, DE BIASI, SARA, NASI, Milena, COSSARIZZA, Andrea, PINTI, Marcello   +5 more
openaire   +3 more sources

Sphingolipids and mitochondrial function, lessons learned from yeast

Microbial Cell, 2014
Mitochondrial dysfunction is a hallmark of several neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, but also of cancer, diabetes and rare diseases such as Wilson’s disease (WD) and Niemann Pick type C1 (NPC).
Pieter Spincemaille, Bruno P.A. Cammue, Karin Thevissen   +2 more
doaj   +1 more source

Evaluation of bioenergetic and mitochondrial function in liver transplantation [PDF]

Clinical and Molecular Hepatology, 2019
Background/Aims We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation.
Rui Miguel Martins, João Soeiro Teodoro, Emanuel Furtado, Anabela Pinto Rolo, Carlos Marques Palmeira, José Guilherme Tralhão   +5 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source