The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion. [PDF]
, 2012 Mitochondria mediate dual metabolic and Ca(2+) shuttling activities. While the former is required for Ca(2+) signalling linked to insulin secretion, the role of the latter in β cell function has not been well understood, primarily because the molecular ...
Fishman, Daniel +8 more
core +5 more sources
Frontiers in Physiology, 2020 BackgroundWe recently reported a method using positron emission tomography (PET) and the tracer 18F-labeled tetraphenylphosphonium (18F-TPP+) for mapping the tissue (i.e., cellular plus mitochondrial) membrane potential (ΔΨT) in the myocardium.
Nathaniel M. Alpert +8 more
doaj +1 more source
In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity [PDF]
, 2020 Mitochondria have been widely accepted as the main source of ATP in the cell. The inner mitochondrial membrane (IMM) is important for the maintenance of ATP production and other functions of mitochondria.
Arieli +48 more
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Mitochondrial Transmembrane Potential (ψm) Assay Using TMRM
Bio-Protocol, 2013 During cellular respiration, nutrients are oxidized to generate energy through a mechanism called oxidative phosphorylation, which occurs in the mitochondria.
Isaline Rowe, Alessandra Boletta
doaj +1 more source
How DASPMI reveals mitochondrial membrane potential : fluorescence decay kinetics and steady-state anisotropy in living cells [PDF]
, 2008 Spectroscopic responses of the potentiometric probe 2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide (DASPMI) were investigated in living cells by means of a time- and space-correlated single photon counting technique.
Ramadass, Radhan, Bereiter-Hahn, Jürgen
core +1 more source
Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation
Frontiers in Chemistry, 2020 There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction.
Laura Pala +10 more
doaj +1 more source
Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism [PDF]
, 2018 Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the cell’s fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial dynamics, central to quality control, and sensitizes mitochondrial ...
Hajnóczky, György +4 more
core +3 more sources
Flow Cytometric Detection of Mitochondrial Membrane Potential
Bio-Protocol, 2013 Mitochondrial membrane potential (Δψm) is an important parameter of mitochondrial function and an indicator of cell health. Depletion of Δψm suggests the loss of mitochondrial membrane integrity reflecting the initiation of the proapoptotic signal ...
Hsin-Yi Chang +5 more
doaj +1 more source
Two hit mitochondrial-driven model of synapse loss in neurodegeneration
Neurobiology of Disease, 2021 In healthy neurons, a mitochondrial membrane potential gradient exists whereby membrane potential is highest in the soma and decreases with distance from the nucleus.
Sergei V. Baranov +3 more
doaj +1 more source
Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]
, 2013 Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Bhella, David +3 more
core +2 more sources