Results 21 to 30 of about 498,645 (208)

Early steps in mitochondrial protein import [PDF]

, 1990
The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A., Neupert, Walter, Nicholson, Donald W.   +2 more
core   +1 more source

Mitochondrial Transmembrane Potential (ψm) Assay Using TMRM

Bio-Protocol, 2013
During cellular respiration, nutrients are oxidized to generate energy through a mechanism called oxidative phosphorylation, which occurs in the mitochondria.
Isaline Rowe, Alessandra Boletta
doaj   +1 more source

Characterization of Translocation Contact Sites Involved in the Import of Mitochondrial Proteins [PDF]

, 1987
Import of proteins into the mitochondrial matrix requires translocation across two membranes. Translocational intermediates of mitochondrial proteins, which span the outer and inner membrane simultaneously and thus suggest that translocation occurs in ...
Herzog, Volker, W Neupert, Schwaiger, Martin, M Schwaiger, Neupert, Walter, V Herzog   +5 more
core   +1 more source

Transport of proteins across mitochondrial membranes [PDF]

, 1994
The vast majority of proteins comprising the mitochondrion are encoded by nuclear genes, synthesized on ribosomes in the cytosol, and translocated into the various mitochondrial subcompartments. During this process proteins must cross the lipid membranes
Neupert, Walter
core   +1 more source

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion [PDF]

, 2009
Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively.
Stahlberg, Henning, Laura L. Lackner, Suzanne Hoppins, Nunnari, Jodi, Jodi Nunnari, Henning Stahlberg, Dominguez-Ramirez, Lenin, Lenin Dominguez-Ramirez, Hoppins, Suzanne, Lackner, Laura L., Rachel M. DeVay, DeVay, Rachel M.   +11 more
core   +1 more source

The mitochondrial receptor complex [PDF]

, 1993
The receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins, is responsible for the recognition and translocation of cytosolically synthesized preproteins.
Klei, Ida J. van der; id_orcid, Pfanner, Nikolaus, Schneider, Helmut,, Kiebler, Michael,, Keil, Petra,, Kiebler, Michael, Neupert, Walter, Klei, Ida J. van der,, Klei, Ida J. van der, Pfanner, Nikolaus,, Keil, Petra, Schneider, Helmut, Neupert, Walter,   +12 more
core   +1 more source

Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

Frontiers in Chemistry, 2020
There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction.
Laura Pala, Hans M. Senn, Stuart T. Caldwell, Tracy A. Prime, Stefan Warrington, Thomas P. Bright, Hiran A. Prag, Claire Wilson, Michael P. Murphy, Michael P. Murphy, Richard C. Hartley   +10 more
doaj   +1 more source

A mitochondrial import receptor for the ADP/ATP carrier [PDF]

, 1990
We have identified a mitochondrial outer membrane protein of 72 kd (MOM72) that exhibits the properties of an import receptor for the ADP/ATP carrier (AAC), the most abundant mitochondrial protein.
Söllner, Thomas, Pfanner, Nikolaus, Pfaller, Rupert, Neupert, Walter, Griffiths, Gareth   +4 more
core   +1 more source

Ca ion transport in smooth muscle mitochondria [PDF]

The Ukrainian Biochemical Journal, 2014
Review focuses on the analysis of literature data and own results concerning properties of mitochondria Са2+ transporting systems and their regu­lation.
L. G. Babich, S. G. Shlykov, S. O. Kosterin   +2 more
doaj   +1 more source

Two hit mitochondrial-driven model of synapse loss in neurodegeneration

Neurobiology of Disease, 2021
In healthy neurons, a mitochondrial membrane potential gradient exists whereby membrane potential is highest in the soma and decreases with distance from the nucleus.
Sergei V. Baranov, Abhishek Jauhari, Diane L. Carlisle, Robert M. Friedlander   +3 more
doaj   +1 more source