Results 61 to 70 of about 498,645 (208)

Carbon ions inhibit non-small cell lung cancer cell proliferation by inducing mitochondrial damage

Fushe yanjiu yu fushe gongyi xuebao
We investigated the effects of mitochondrial damage via carbon ion irradiation on the proliferation of human non-small cell lung cancer (A549) cells by monitoring mitochondrial morphological changes, mitochondrial membrane potential transformation ...
ZHANG Tianyi, YANG Pengfei, WANG Jufang, ZHOU Heng   +3 more
doaj   +1 more source

Wafer-scale mitochondrial membrane potential assays [PDF]

Lab on a Chip, 2012
It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process. To evaluate these biochemical parameters, current technology requires several hundred milligrams of isolated mitochondria for functional assays.
Tae-Sun, Lim, Antonio, Davila, Katayoun, Zand, Douglas C, Wallace, Peter J, Burke   +4 more
openaire   +2 more sources

Mitochondrial protein import [PDF]

, 1988
Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of aminoterminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa.
Hawlitschek, Gerhard, Schneider, Helmut, Tropschug, Maximilian, Hartl, Franz-Ulrich, Neupert, Walter, Schmidt, Bernd   +5 more
core   +1 more source

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

Frontiers in Genetics, 2015
Mutations in PARK2, encoding Parkin, cause an autosomal recessive form of juvenile Parkinson Disease (JPD). The aim of the present study was to investigate the impact of PARK2 mutations on mitochondrial function and morphology in human skin fibroblasts ...
Maria Clara eZanellati, Valentina eMonti, Chiara eBarzaghi, Chiara eReale, Nardo eNardocci, Alberto eAlbanese, Enza Maria eValente, Daniele eGhezzi, Barbara eGaravaglia   +8 more
doaj   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
Williams, Roderick A M, Mottram, Jeremy C, Roderick A M Williams, Benjamin Cull, Mottram Jeremy C., Coombs, Graham H, Williams Roderick A. M., Cull Benjamin, Terry K Smith, Jeremy C. Mottram (112563), Graham H. Coombs (164011), Smith Terry K., Terry K. Smith (112550), Mottram, Jeremy C., Benjamin Cull (164010), Coombs Graham H., Coombs, Graham H., Smith, Terry K., Jeremy C Mottram, Smith, Terry K, Cull, Benjamin, Williams, Roderick A. M., Roderick A. M. Williams (164005), Graham H Coombs   +23 more
core   +1 more source

A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases

Saudi Pharmaceutical Journal
The mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases.
Adel Alghamdi
doaj   +1 more source

Inherent mitochondrial activity influences specification of the germ line in pluripotent stem cells

Heliyon, 2020
Herein we investigated whether inherent differences in mitochondrial activity in mouse pluripotent cells could be used to identify populations with an intrinsic ability to differentiate into primordial germ cells (PGCs).
Alisha M. Bothun, Dori C. Woods
doaj   +1 more source

Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis [PDF]

Circulation Research, 2001
Mitochondria comprise ≈30% of the total intracellular volume within a mammalian cardiomyocyte.1 2 Not surprisingly, subtle alterations in mitochondrial function or membrane potential can have a dramatic influence on cardiomyocyte energy production and, ultimately, the health of an individual cell.
openaire   +2 more sources

Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner

BMC Biology
Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology.
Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui   +5 more
doaj   +1 more source

Integrity of the plasma membrane, the acrosomal membrane, and the mitochondrial membrane potential of sperm in Nelore bulls from puberty to sexual maturity

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016
This study evaluated the plasma membrane integrity, acrosomal membrane integrity, and mitochondrial membrane potential of Nelore bull sperm from early puberty to early sexual maturity and their associations with sperm motility and vigor, the mass ...
L.S.L.S. Reis, A.A. Ramos, A.S. Camargos, E. Oba   +3 more
doaj   +1 more source