Results 21 to 30 of about 273,415 (305)

Mitochondrial membrane tension governs fission [PDF]

Cell Reports, 2018
Abstract During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide, or reverse upon disassembly of the machinery. However, a role for membrane tension in mitochondrial fission, although speculated,
Mahecic, Dora, Carlini, Lina, Kleele, Tatjana, Colom Diego, Adai, Goujon, Antoine, Matile, Stefan, Roux, Aurélien, Manley, Suliana   +7 more
openaire   +7 more sources

Mitochondrial Membrane Potential Assay [PDF]

, 2016
Mitochondrial function, a key indicator of cell health, can be assessed by monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membrane potential indicator (m-MPI) to detect changes in MMP in HepG2 cells.
Srilatha, Sakamuru, Matias S, Attene-Ramos, Menghang, Xia   +2 more
openaire   +2 more sources

Cardiolipin, Non-Bilayer Structures and Mitochondrial Bioenergetics: Relevance to Cardiovascular Disease

Cells, 2021
The present review is an attempt to conceptualize a contemporary understanding about the roles that cardiolipin, a mitochondrial specific conical phospholipid, and non-bilayer structures, predominantly found in the inner mitochondrial membrane (IMM ...
Edward S. Gasanoff, Lev S. Yaguzhinsky, Győző Garab   +2 more
doaj   +1 more source

Protocol for engineering and validating a synthetic mitochondrial intermembrane bridge in mammalian cells

STAR Protocols, 2022
Summary: Membrane contact sites are recognized as critical means of intercompartmental communication. Here, we describe a protocol for engineering and validating a synthetic bridge between the inner and outer mitochondrial membranes to support ...
Gunjan Purohit, Martonio Ponte Viana, Oleh Khalimonchuk   +2 more
doaj   +1 more source

Naja mossambica mossambica Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function

Toxins, 2019
Cobra venom cardiotoxins (CVCs) can translocate to mitochondria to promote apoptosis by eliciting mitochondrial dysfunction. However, the molecular mechanism(s) by which CVCs are selectively targeted to the mitochondrion to disrupt mitochondrial function
Boris Zhang, Feng Li, Zhengyao Chen, Indira H. Shrivastava, Edward S. Gasanoff, Ruben K. Dagda   +5 more
doaj   +1 more source

Regulation of Mitochondrial Dynamics by Proteolytic Processing and Protein Turnover

Antioxidants, 2018
The mitochondrial network is a dynamic organization within eukaryotic cells that participates in a variety of essential cellular processes, such as adenosine triphosphate (ATP) synthesis, central metabolism, apoptosis and inflammation.
Sumaira Ali, Gavin P. McStay
doaj   +1 more source

Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy

JACC: Basic to Translational Science, 2023
Summary: Mitochondrial dysfunction is suggested to be a major contributor for the progression of heart failure (HF). Here we examined the role of syntaxin 17 (STX17) in the progression of HF. Cardiac-specific Stx17 knockout manifested cardiac dysfunction
Haixia Xu, MD, Xiang Wang, MD, Wenjun Yu, MD, Shiqun Sun, MD, Ne N. Wu, MD, Junbo Ge, MD, PhD, Jun Ren, MD, PhD, Yingmei Zhang, MD, PhD   +7 more
doaj   +1 more source

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Frontiers in Neuroscience, 2020
Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD). Although its role in neurotransmission is well established, the precise role of this protein
Valentina Gilmozzi, Giovanna Gentile, Maria Paulina Castelo Rueda, Andrew A. Hicks, Peter P. Pramstaller, Peter P. Pramstaller, Alessandra Zanon, Martin Lévesque, Irene Pichler   +8 more
doaj   +1 more source

Study of the transfer of phospholipids from the endoplasmic reticulum to the outer and inner mitochondrial membranes

Journal of Lipid Research, 1971
Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj   +1 more source

Hsp70 at the membrane: driving protein translocation

BMC Biology, 2018
Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—such as those in the membranes of the ...
Elizabeth A. Craig
doaj   +1 more source