Results 41 to 50 of about 6,525,414 (422)

Effect of the mitochondrial unfolded protein response on hypoxic death and mitochondrial protein aggregation [PDF]

Cell Death & Disease, 2021
AbstractMitochondria are the main oxygen consumers in cells and as such are the primary organelle affected by hypoxia. All hypoxia pathology presumably derives from the initial mitochondrial dysfunction. An early event in hypoxic pathology in C. elegans is disruption of mitochondrial proteostasis with induction of the mitochondrial unfolded protein ...
Chun-Ling Sun, C. Michael Crowder, Junyi Yan, Seokyung Shin, Seokyung Shin, Marc Van Gilst   +5 more
openaire   +5 more sources

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system [PDF]

Open Biology, 2017
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport in an unfolded state
Piotr Bragoszewski, Michal Turek, Agnieszka Chacinska   +2 more
doaj   +1 more source

Targeting and Insertion of Membrane Proteins in Mitochondria

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from
Ross Eaglesfield, Kostas Tokatlidis
doaj   +1 more source

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
core   +1 more source

Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex [PDF]

, 2002
The inner mitochondrial membrane harbors a large number of proteins that display a wide range of topological arrangements. The majority of these proteins are encoded in the cell\u27s nucleus, but a few polytopic proteins, all subunits of respiratory ...
Stuart, Rosemary A.
core   +2 more sources

Minocycline impedes mitochondrial-dependent cell death and stabilizes expression of hypoxia inducible factor-1α in spinal cord injury

Archives of Medical Science, 2019
Introduction One of the crucial mechanisms following spinal cord injury is mitochondria-associated cell death. Minocycline, an anti-inflammatory drug, is well known to impede mitochondrial cell death.
Guolei Zhang, Junpu Zha, Junchuan Liu, Jun Di   +3 more
doaj   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ades, Allmann, Ardail, Ardail, Ardail, Attardi, Baker, Biermans, Biermans, Brdiczka, Brdiczka, Eilers, Glick, Hackenbrock, Hackenbrock, Hackenbrock, Hartl, Hartl, Hines, Hwang, Kellems, Kiebler, Knoll, Lill, Lithgow, Malhotra, Martin, Marzuki, McEnery, Murakami, Nicolay, Ohlendieck, Pain, Pfanner, Pfanner, Pfanner, Pon, Rassow, Rassow, Rassow, Rojo, Schleyer, Schwaiger, Stuart, Suissa, Söllner, Söllner, Söllner, van Venetië, Vestweber, Vestweber, Vignais, Watson, Werner, Wienhues, Zara   +55 more
core   +1 more source

Biosynthesis and assembly of mitochondrial proteins [PDF]

, 1983
A Scarpa, A Tzagoloff, AP Autor, AS Lewin, B Hennig, BC Pressman, C Côte, C Zwizinski, D Lloyd, DD Sabatini, DI Meyer, DI Meyer, DL Stigall, E Schmelzer, G Blobel, G Hallermayer, G Kreibich, G Macino, G Palade, G Schatz, G Schatz, GC Shore, H Freitag, H Freitag, H Korb, H Weiss, HW Heldt, J Subik, JG Conboy, JG Conboy, K Mihara, K Mihara, K Yamauchi, K Yamauchi, LAM Hensgens, M Klingenberg, M Mori, M Mori, M Schleyer, M Teintze, M-L Maccecchini, M-L Maccecchini, MA Harmey, N Nabi, N Nabi, N Nelson, N-H Chua, N-H Chua, P Böhni, P Sonderegger, P Sonderegger, P Walter, P Walter, P Walter, P Walter, PC Heinrich, PC Mcada, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RC Jackson, RN Dubois, S Matsuura, S Miura, SM Gasser, SN Graven, T Morita, W Neupert, W Sebald, W Wickner, Y Okada, Y Raymond, Y Raymond   +75 more
core   +4 more sources

Shexiang Baoxin Pill Corrects Metabolic Disorders in a Rat Model of Metabolic Syndrome by Targeting Mitochondria

Frontiers in Pharmacology, 2018
Background: Metabolic syndrome (MS) is a global epidemic that has great socioeconomic and public health implications. This study reports observed effects of the Shexiang Baoxin Pill (SBP) in a rat model of MS and explores its underlying mechanisms of ...
Dan Wei, Ningning Zheng, Lanyan Zheng, Leting Wang, Liang Song, Luning Sun   +5 more
doaj   +1 more source

Players in Mitochondrial Dynamics and Female Reproduction

Frontiers in Molecular Biosciences, 2021
Mitochondrial dynamics (fission and fusion) are essential physiological processes for mitochondrial metabolic function, mitochondrial redistribution, and mitochondrial quality control.
Weiwei Zou, Weiwei Zou, Weiwei Zou, Dongmei Ji, Dongmei Ji, Dongmei Ji, Zhiguo Zhang, Zhiguo Zhang, Zhiguo Zhang, Li Yang, Yunxia Cao, Yunxia Cao, Yunxia Cao   +12 more
doaj   +1 more source