Results 1 to 10 of about 26,194 (236)

Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation [PDF]

Signal Transduction and Targeted Therapy, 2022
Yu Chen, Jingchun Wang, Yongsheng Li
doaj   +2 more sources

Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis. [PDF]

Redox Biol
Jeon KI, Kumar A, Brookes PS, Nehrke K, Huxlin KR.   +4 more
europepmc   +2 more sources

Withdrawal: Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production. [PDF]

J Biol Chem, 2022
Guo Q, Zhao H, Cheng H, Kang H, Dong Y, Peng R, Zhu M, Fang Z, Li F.   +8 more
europepmc   +3 more sources

Mitochondrial Pyruvate Carrier 1 as a Novel Prognostic Biomarker in Non-Small Cell Lung Cancer. [PDF]

Technol Cancer Res Treat
Zou H, Yin Y, Xiong K, Luo X, Sun Z, Mao B, Xie Q, Tan M, Kong R.   +8 more
europepmc   +2 more sources

Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. [PDF]

Nat Metab, 2020
McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN.   +13 more
europepmc   +3 more sources

Mitochondrial pyruvate carrier 2 mitigates acute kidney injury via sustaining mitochondrial metabolism. [PDF]

Int J Biol Sci
Wu L, Li Q, Lu F, Qian L, Pan Y, Chen C, Huang Z, Duan S, Zhang B, Liang H, Xing C, Mao H, Yuan Y.   +12 more
europepmc   +2 more sources

Metabolism-focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer. [PDF]

Mol Carcinog
Furusawa T, Cavero R, Liu Y, Li H, Xu X, Andresson T, Reinhold W, White O, Boufraqech M, Meyer TJ, Hartmann O, Diefenbacher ME, Pommier Y, Weyemi U.   +13 more
europepmc   +3 more sources

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

Cell Reports, 2020
Summary: Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer’s disease (AD), and the comprehension of the underlying mechanisms appears crucial to ...
Alice Rossi, Giulia Rigotto, Giulia Valente, Valentina Giorgio, Emy Basso, Riccardo Filadi, Paola Pizzo   +6 more
doaj   +1 more source

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

BMC Nephrology, 2020
Background Mitochondrial dysfunction contributes to the pathogenesis of diabetic nephropathy (DN). Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role in the transport of pyruvate into mitochondrial ...
Huanhuan Zhu, Huiting Wan, Lin Wu, Qing Li, Simeng Liu, Suyan Duan, Zhimin Huang, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan   +10 more
doaj   +1 more source

Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan

Biomolecules, 2020
As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration ...
Jane L. Buchanan, Eric B. Taylor
doaj   +1 more source