Results 21 to 30 of about 26,194 (236)

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease [PDF]

Biomolecules, 2023
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy stored in this nutrient to be fully harnessed to generate ATP or
Kyle S. McCommis, Brian N. Finck
doaj   +2 more sources

Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors [PDF]

Molecular & Cellular Oncology, 2018
Lactate-based metabolic symbiosis between glycolytic and oxidative cancer cells is known to facilitate tumor growth. We have recently demonstrated that 7ACC2 blocks extracellular lactate uptake via the inhibition of mitochondrial pyruvate carrier.
Catherine Vander Linden, Cyril Corbet
doaj   +2 more sources

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter [PDF]

Scientific Reports, 2018
The active transport of glycolytic pyruvate across the inner mitochondrial membrane is thought to involve two mitochondrial pyruvate carrier subunits, MPC1 and MPC2, assembled as a 150 kDa heterotypic oligomer.
Raghavendra Sashi Krishna Nagampalli, José Edwin Neciosup Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor Gobbi Sebinelli, Richard Marcel Bruno Moreira Girard, Carolline Fernanda Rodrigues Ascenção, Angela Maria Fala, Bianca Alves Pauletti, Sílvio Roberto Consonni, Juliana Ferreira de Oliveira, Amanda Cristina Teixeira Silva, Kleber Gomes Franchini, Adriana Franco Paes Leme, Ariel Mariano Silber, Pietro Ciancaglini, Isabel Moraes, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio   +19 more
doaj   +2 more sources

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. [PDF]

Sci Immunol, 2023
Zhu B, Wei X, Narasimhan H, Qian W, Zhang R, Cheon IS, Wu Y, Li C, Jones RG, Kaplan MH, Vassallo RA, Braciale TJ, Somerville L, Colca JR, Pandey A, Jackson PEH, Mann BJ, Krawczyk CM, Sturek JM, Sun J.   +19 more
europepmc   +3 more sources

Insights on the Quest for the Structure–Function Relationship of the Mitochondrial Pyruvate Carrier [PDF]

Biology, 2020
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated.
José Edwin Neciosup Quesñay, Naomi L. Pollock, Raghavendra Sashi Krishna Nagampalli, Sarah C. Lee, Vijayakumar Balakrishnan, Sandra Martha Gomes Dias, Isabel Moraes, Tim R. Dafforn, Andre Luis Berteli Ambrosio   +8 more
doaj   +2 more sources

The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice [PDF]

Molecular Metabolism
Objective: The mitochondrial pyruvate carrier (MPC) occupies a critical node in intermediary metabolism, prompting interest in its utility as a therapeutic target for the treatment of obesity and cardiometabolic disease.
Christopher E. Shannon, Terry Bakewell, Marcel J. Fourcaudot, Iriscilla Ayala, Annie A. Smelter, Edgar A. Hinostroza, Giovanna Romero, Mara Asmis, Leandro C. Freitas Lima, Martina Wallace, Luke Norton   +10 more
doaj   +2 more sources

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier. [PDF]

Eur J Med Chem
Maram L, Michael JM, Politte H, Srirama VS, Hadji A, Habibi M, Kelly MO, Brookheart RT, Finck BN, Hegazy L, McCommis KS, Elgendy B.   +11 more
europepmc   +2 more sources

The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis. [PDF]

Cancers (Basel), 2021
Ruiz-Iglesias A, Mañes S.
europepmc   +3 more sources

MSDC-0160, a novel clinical-stage mitochondrial pyruvate carrier inhibitor, suppresses osteoclast differentiation and alleviates type 2 diabetes-related bone loss. [PDF]

J Transl Med
Wang C, Hai N, Chen L, Huang Q, Gui Y, Su Y, Lian H, Liang J, Zhao J, Xu J, Liu Q.   +10 more
europepmc   +2 more sources

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening. [PDF]

Biomedicines, 2022
Hegazy L, Gill LE, Pyles KD, Kaiho C, Kchouk S, Finck BN, McCommis KS, Elgendy B.   +7 more
europepmc   +3 more sources