Results 101 to 110 of about 2,844 (161)

Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake

Molecular Metabolism
Objective: Glucose-1,6-bisphosphate (G-1,6-BP), a byproduct of glycolysis that is synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons.
Motahareh Solina Safari, Priska Woerl, Carolin Garmsiri, Dido Weber, Marcel Kwiatkowski, Madlen Hotze, Louisa Kuenkel, Luisa Lang, Matthias Erlacher, Ellen Gelpi, Johannes A. Hainfellner, Gottfried Baier, Gabriele Baier-Bitterlich, Stephanie zur Nedden   +13 more
doaj   +1 more source

Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism

The Journal of Clinical Investigation
Carbohydrates and lipids provide the majority of substrates to fuel mitochondrial oxidative phosphorylation. Metabolic inflexibility, defined as an impaired ability to switch between these fuels, is implicated in a number of metabolic diseases.
Piyarat Siripoksup, Guoshen Cao, Ahmad A. Cluntun, J. Alan Maschek, Quentinn Pearce, Marisa J. Brothwell, Mi-Young Jeong, Hiroaki Eshima, Patrick J. Ferrara, Precious C. Opurum, Ziad S. Mahmassani, Alek D. Peterlin, Shinya Watanabe, Maureen A. Walsh, Eric B. Taylor, James E. Cox, Micah J. Drummond, Jared Rutter, Katsuhiko Funai   +18 more
doaj   +1 more source

Activation of the integrated stress response in human hair follicles.

PLoS ONE
Unravelling how energy metabolism and stress responses are regulated in human scalp hair follicles could reveal novel insights into the controls of hair growth and provide new targets to manage hair loss disorders. The Mitochondrial Pyruvate Carrier (MPC)
Derek Pye, Rachel Scholey, Sin Ung, Madoc Dawson, Asim Shahmalak, Talveen S Purba   +5 more
doaj   +1 more source

Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis

Redox Biology
Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or infection. However, their persistent deposition of disorganized extracellular matrix can also cause corneal fibrosis and visual impairment.
Kye-Im Jeon, Ankita Kumar, Paul S. Brookes, Keith Nehrke, Krystel R. Huxlin   +4 more
doaj   +1 more source

The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice

Molecular Metabolism
Objective: The mitochondrial pyruvate carrier (MPC) occupies a critical node in intermediary metabolism, prompting interest in its utility as a therapeutic target for the treatment of obesity and cardiometabolic disease.
Christopher E. Shannon, Terry Bakewell, Marcel J. Fourcaudot, Iriscilla Ayala, Annie A. Smelter, Edgar A. Hinostroza, Giovanna Romero, Mara Asmis, Leandro C. Freitas Lima, Martina Wallace, Luke Norton   +10 more
doaj   +1 more source

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants [PDF]

, 2015
Aggeliki-Stefania Basogianni, Athanassios D. Velentzas, Dimitrios J. Stravopodis, Efthimios Paronis, Ema Anastasiadou, Eumorphia G. Konstantakou, Evangelos Balafas, Gerassimos E. Voutsinas, Konstantinos N. Syrigos, Nikolaos Kostomitsopoulos   +9 more
core   +1 more source

Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart

JCI Insight
The clinical therapy for treating acute myocardial infarction is primary percutaneous coronary intervention (PPCI). PPCI is effective at reperfusing the heart; however, the rapid reintroduction of blood can cause ischemia-reperfusion (I/R).
Joseph R. Visker, Ahmad A. Cluntun, Jesse N. Velasco-Silva, David R. Eberhardt, Luis Cedeño-Rosario, Thirupura S. Shankar, Rana Hamouche, Jing Ling, Hyoin Kwak, J. Yanni Hillas, Ian Aist, Eleni Tseliou, Sutip Navankasattusas, Dipayan Chaudhuri, Gregory S. Ducker, Stavros G. Drakos, Jared Rutter   +16 more
doaj   +1 more source

Identification of a mitochondrial target of Thiazolidinedione insulin sensitizers (mTOT)— relationship to newly identified mitochondrial pyruvate carrier proteins [PDF]

, 2013
et al,, Finck, Brian N, Vigueira, Patrick A   +2 more
core   +2 more sources

How one nutrient controls cell size. [PDF]

Elife
Montero A, Finley LWS.
europepmc   +1 more source

MSDC-0160, a novel clinical-stage mitochondrial pyruvate carrier inhibitor, suppresses osteoclast differentiation and alleviates type 2 diabetes-related bone loss. [PDF]

J Transl Med
Wang C, Hai N, Chen L, Huang Q, Gui Y, Su Y, Lian H, Liang J, Zhao J, Xu J, Liu Q.   +10 more
europepmc   +1 more source